{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:22:46Z","timestamp":1777393366851,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T00:00:00Z","timestamp":1406246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2014,7,25]]},"abstract":"<jats:p>\n                    We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD). We examined the posterior cingulate gyri of 228 subjects using VSRAD and\n                    <jats:sup>1<\/jats:sup>\n                    H MRS in addition to conventional cerebrospinal fluid biomarkers at baseline. At the 3-year follow-up, the 228 subject were classified as follows: 93 healthy subjects, 42 MCI-non-converters (MCI-NC), 25 MCI-converters to AD (MCI-C), 44 AD, 8 dementia with Lewy bodies (DLB), 5 normal pressure hydrocephalus, and 11 patients with other neurological diseases. Our results demonstrated that subjects with increased medial temporal atrophy (MTA) severity on VSRAD, increased Cho\/Cr, MI\/Cr ratio, and decreased NAA\/Cr and NAA\/MI ratio on\n                    <jats:sup>1<\/jats:sup>\n                    H MRS at baseline were at risk of dementia due to AD. Receiver operating characteristic analysis showed that severity of MTA and the NAA\/MI ratio distinguished patients with AD and MCI-C from controls. Furthermore, the 118 subjects without dementia and MTA showing only a decreased NAA\/MI ratio at baseline developed to MCI-C, AD, and DLB 3 years later.\n                    <jats:sup>1<\/jats:sup>\n                    H MRS detected biochemical abnormalities preceding brain atrophy and cognitive decline. VSRAD combined with\n                    <jats:sup>1<\/jats:sup>\n                    H MRS may be routinely applied to screen for MCI\/AD and prodromal AD in clinical practice.\n                  <\/jats:p>","DOI":"10.3233\/jad-132786","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T12:58:59Z","timestamp":1528117139000},"page":"1207-1222","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Utility of SPM8 plus DARTEL (VSRAD) Combined with Magnetic Resonance Spectroscopy as Adjunct Techniques for Screening and Predicting Dementia due to Alzheimer's Disease in Clinical Practice"],"prefix":"10.1177","volume":"41","author":[{"given":"Masaaki","family":"Waragai","sequence":"first","affiliation":[{"name":"Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Hata","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology of Brain Diseases (Department of Neurology), Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Geriatrics &amp; Gerontology, Division of Brain Science Institute of Development, Aging and Cancer Tohoku University, Tohoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ohrui","sequence":"additional","affiliation":[{"name":"Division of Geriatric Pharmacotherapy, Institute of Development, Aging and Cancer, Tohoku University, Tohoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Kurihama Medical and Addiction Center, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madoka","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuei","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Moriya","sequence":"additional","affiliation":[{"name":"Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomichi","family":"Iwai","sequence":"additional","affiliation":[{"name":"Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Uemura","sequence":"additional","affiliation":[{"name":"Higashi Matsudo Municipal Hospital, Matsudo, Takatsuka shinden, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,25]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-132786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-132786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:00:40Z","timestamp":1777370440000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-132786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7,25]]}},"alternative-id":["10.3233\/JAD-132786"],"URL":"https:\/\/doi.org\/10.3233\/jad-132786","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,25]]}}}