{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:02:03Z","timestamp":1790488923020,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2014,10,10]]},"abstract":"\n Background\/Objective:<\/jats:title>\n We examine whether midlife vascular risk factors (VRFs) are associated with increased risk of incident Alzheimer\u2019s disease (AD) in a systematic review and meta-analysis of published cohort studies.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Original cohort studies were included if they reported adjusted combined odds ratio (COR) and corresponding 95% confidence intervals (CIs) or enough information to quantify the association between risk for AD in late-life and baseline VRFs of midlife.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n There were positive and significant associations between high blood pressure (COR 1.31; 95% CI: 1.01\u20131.70), hypercholesterolemia (COR 1.72; 95% CI: 1.32\u20132.24), obesity (COR 1.88; 95% CI: 1.32\u20132.69), and diabetes mellitus in midlife (COR 1.4; 95% CI: 1.25\u20131.57). Smoking and hyperhomocysteinemia (although only one high-quality paper) were also associated with an increased risk of AD generally.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n These results strengthen the epidemiological evidence that VRFs of midlife significantly increase risk for AD.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/jad-140954","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T13:16:58Z","timestamp":1528118218000},"page":"1295-1310","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":127,"title":["Midlife Vascular Risk Factors and the Risk of Alzheimer's Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"42","author":[{"given":"Xiang-Fei","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China"},{"name":"Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China"},{"name":"Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Fu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Shan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China"},{"name":"Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China"},{"name":"Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,10]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-140954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-140954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:00:53Z","timestamp":1777370453000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-140954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10,10]]}},"alternative-id":["10.3233\/JAD-140954"],"URL":"https:\/\/doi.org\/10.3233\/jad-140954","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/s12035-014-8878-3","asserted-by":"object"}]},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,10]]}}}