{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:34:33Z","timestamp":1777394073848,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2015,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    There is a growing consensus that disease-modifying therapies must be given at the prodromal or preclinical stages of Alzheimer\u2019s disease (AD) to be effective. A major unmet need is to develop and validate sensitive measures to track disease progression in these populations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To generate novel statistically-derived composites from standard scores, which have increased sensitivity in the assessment of change from baseline in prodromal AD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    An empirically based method was employed to generate domain specific, global, and cognitive-functional novel composites. The novel composites were compared and contrasted with each other, as well as standard scores for their ability to track change from baseline. The longitudinal characteristics and power to detect decline of the measures were evaluated. Data from participants in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study characterized as mild cognitively impaired with high neocortical amyloid-\u03b2 burden were utilized for the study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The best performing standard scores were CDR Sum-of-Boxes and MMSE. The statistically-derived novel composites performed better than the standard scores from which they were derived. The domain-specific composites generally did not perform as well as the global composites or the cognitive-functional composites.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    A systematic method was employed to generate novel statistically-derived composite measures from standard scores. Composites comprised of measures including function and multiple cognitive domains appeared to best capture change from baseline. These composites may be useful to assess progression or lack thereof in prodromal AD. However, the results should be replicated and validated using an independent clinical sample before implementation in a clinical trial.\n                  <\/jats:p>","DOI":"10.3233\/jad-143015","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T11:51:59Z","timestamp":1435751519000},"page":"1079-1089","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer\u2019s Disease Trials: An AIBL Study"],"prefix":"10.1177","volume":"46","author":[{"given":"Samantha C.","family":"Burnham","sequence":"first","affiliation":[{"name":"CSIRO Digital Productivity Flagship, Floreat, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Raritan, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"CSIRO Digital Productivity Flagship, North Ryde, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Titusville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Ropacki","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Fremont, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Novak","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Raritan, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ames","sequence":"additional","affiliation":[{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia"},{"name":"National Ageing Research Institute, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Ellis","sequence":"additional","affiliation":[{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research &amp; Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia"},{"name":"Sir James McCusker Alzheimer\u2019s Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"Cogstate, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute (MHRI), The University of Melbourne, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Romano","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Raritan, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia"},{"name":"Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Savage","sequence":"additional","affiliation":[{"name":"ARC Centre of Excellence in Cognition and its Disorders, and Department of Psychology, Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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