{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:53:39Z","timestamp":1785423219809,"version":"3.56.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2015,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Although plasma amyloid-\u03b2 (A\u03b2) levels have been evaluated as a\n          possible diagnostic marker of Alzheimer\u2019s disease (AD), the findings are inconsistent.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    The present study aimed to validate plasma levels of\n            A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    , A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    , and the A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio as\n          biomarkers of AD in subjects with early-onset AD (EOAD) without familial AD genetic\n          mutations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Patients with sporadic EOAD (sEOAD) were prospectively recruited by\n          nine neurology clinics. Plasma levels of A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    and A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    were measured\n          using a sandwich enzyme-linked immunosorbent assay (ELISA) in 100 sEOAD (50\u201369 year-old)\n          and 46 age-matched normal control subjects (50\u201372 year-old). Cerebrospinal fluid (CSF) was\n          obtained from 32 sEOAD subjects and 25 controls. The integrity of the blood-brain barrier\n          was assessed using the CSF\/plasma albumin ratio.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The plasma levels of A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    were significantly lower,\n          while the A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio was significantly higher in sEOAD patients\n          than in controls. The levels of A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    , A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    , and the\n            A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio did not differ in relation to the\n                    <jats:italic>APOE<\/jats:italic>\n                    <jats:italic>\u025b<\/jats:italic>\n                    4 allele. The CSF\/plasma albumin ratio was comparable between the two\n          groups, and the plasma parameters of A\u03b2 proteins were not significantly associated. A\n          multivariate analysis revealed that an increased A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio is\n          valuable for the discrimination of sEOAD from controls (\u03b2=\u200a0.344,\n                    <jats:italic>p<\/jats:italic>\n                    \u200a=\u200a0.000). The area under the ROC curve for the\n            A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio was 0.76, and a cut-off ratio of 5.87 was\n          suggested to have 70% sensitivity and 68% specificity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The plasma A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio had moderate\n          validity for the discrimination of sEOAD patients from age-matched controls.\n                  <\/jats:p>","DOI":"10.3233\/jad-143018","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T16:54:27Z","timestamp":1445964867000},"page":"1043-1050","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Elevation of the Plasma A\u03b2\n                    <sub>40<\/sub>\n                    \/A\u03b2\n                    <sub>42<\/sub>\n                    Ratio as a Diagnostic          Marker of Sporadic Early-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"48","author":[{"given":"Hyeong Jun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University College of\r          Medicine, Dong-A University Hospital, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Sik","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeromi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Seok","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of\r          Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ilsan Hospital, National Health\r          Insurance Corporation, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pusan National University Hospital,\r          Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gachon University, College of\r          Medicine, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, Myongii Hospital, Seonam University\r          College of Medicine, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Mokdong\r          Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inha University School of Medicine,\r          Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Ah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon\r          Hospital, Bucheon, 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