{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:49:31Z","timestamp":1790693371310,"version":"4.1.0"},"reference-count":184,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2015,7,9]]},"DOI":"10.3233\/jad-143210","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:39:06Z","timestamp":1436888346000},"page":"33-47","source":"Crossref","is-referenced-by-count":50,"title":["A Unified Hypothesis of Early- and Late-Onset Alzheimer\u2019s Disease Pathogenesis"],"prefix":"10.1177","volume":"47","author":[{"given":"Craig S.","family":"Atwood","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI,\u00a0USA"},{"name":"Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI, USA"},{"name":"School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Bowen","sequence":"additional","affiliation":[{"name":"Patiently, LLC, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"Suppl 8","key":"10.3233\/JAD-143210_ref1","first-page":"S193","article-title":"The burden of dementia","volume":"13","author":"Cotter","year":"2007","journal-title":"Am J Manag Care"},{"key":"10.3233\/JAD-143210_ref3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The genetics of Alzheimer disease: Back to the future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"key":"10.3233\/JAD-143210_ref6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archneur.1983.04050030037006","article-title":"A comparison of clinical features inearly- and late-onset primary degenerative dementia. One entity ortwo?","volume":"40","author":"Seltzer","year":"1983","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-143210_ref7","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1212\/WNL.0b013e31821a44dd","article-title":"Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease","volume":"76","author":"Balasa","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref8","first-page":"212","article-title":"Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer\u2019s disease","volume":"7","author":"Nochlin","year":"1993","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-143210_ref9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000017024","article-title":"Age at onset and regional cerebral glucose metabolism in Alzheimer\u2019s disease","volume":"9","author":"Yasuno","year":"1998","journal-title":"Dement Geriatr Cogn Dis"},{"key":"10.3233\/JAD-143210_ref10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3233\/JAD-2012-121129","article-title":"Highly pathogenic Alzheimer\u2019s disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes","volume":"32","author":"Bialopiotrowicz","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref11","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1523\/JNEUROSCI.23-17-06914.2003","article-title":"DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3","volume":"23","author":"McPhie","year":"2003","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jnen\/64.2.93","article-title":"Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence","volume":"64","author":"Atwood","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-143210_ref13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/1097-4547(20000715)61:2<128::AID-JNR2>3.0.CO;2-H","article-title":"Cyclin\u2019 toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease","volume":"61","author":"Raina","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-143210_ref14","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1523\/JNEUROSCI.3347-04.2004","article-title":"Divide and die: Cell cycle events as triggers of nerve cell death","volume":"24","author":"Herrup","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.3233\/JAD-143210_ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2009.01.007","article-title":"Neural cell cycle dysregulation and central nervous system diseases","volume":"89","author":"Wang","year":"2009","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-143210_ref16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuint.2008.10.013","article-title":"Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer\u2019s disease","volume":"54","author":"Lee","year":"2009","journal-title":"Neurochem Int"},{"key":"10.3233\/JAD-143210_ref17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbadis.2006.10.008","article-title":"Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis","volume":"1772","author":"Neve","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-143210_ref18","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nn1928","article-title":"Male pheromone-stimulated neurogenesis in the adult female brain: Possible role in mating behavior","volume":"10","author":"Mak","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-143210_ref19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1095\/biolreprod.108.075341","article-title":"Rapid induction of cell proliferation in theadult female ungulate brain (Ovis aries) associated with activation of the reproductive axis by exposure tounfamiliar males","volume":"80","author":"Hawken","year":"2009","journal-title":"Biol Reprod"},{"key":"10.3233\/JAD-143210_ref20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-5793(95)01221-Y","article-title":"Tau isoform expression and phosphorylation state duringdifferentiation of cultured neuronal cells","volume":"375","author":"Smith","year":"1995","journal-title":"FEBS Lett"},{"key":"10.3233\/JAD-143210_ref21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-3835(96)04186-9","article-title":"Inhibition of insulin like growth factor II autocrine growth of Wilms\u2019 tumor by suramin in vitro and in vivo","volume":"103","author":"Vincent","year":"1996","journal-title":"Cancer Lett"},{"key":"10.3233\/JAD-143210_ref22","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1523\/JNEUROSCI.21-08-02661.2001","article-title":"DNA replication precedes neuronal cell death in Alzheimer\u2019s disease","volume":"21","author":"Yang","year":"2001","journal-title":"J\u00a0Neurosci"},{"key":"10.3233\/JAD-143210_ref23","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer\u2019s disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref24","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"JNeuropathol Exp Neurol"},{"key":"10.3233\/JAD-143210_ref25","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1073\/pnas.90.11.5066","article-title":"Theabnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation duringdevelopment","volume":"90","author":"Goedert","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-143210_ref26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1471-4159.2003.02196.x","article-title":"Amyloid-beta-induced toxicity ofprimary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5expression","volume":"88","author":"Liu","year":"2004","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-143210_ref27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0304-3835(01)00547-X","article-title":"EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells","volume":"169","author":"Zhu","year":"2001","journal-title":"Cancer Lett"},{"key":"10.3233\/JAD-143210_ref28","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1210\/en.2002-220706","article-title":"Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: Activation of Janus kinase\/signal transducer and activator of transcription and phosphoinositol 3-kinase\/Akt pathways","volume":"144","author":"Carvalho","year":"2003","journal-title":"Endocrinology"},{"key":"10.3233\/JAD-143210_ref29","first-page":"1","article-title":"The ERK cascade as a prototype of MAPK signaling pathways","volume":"250","author":"Rubinfeld","year":"2004","journal-title":"Methods Mol Biol"},{"key":"10.3233\/JAD-143210_ref30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0736-5748(00)00010-1","article-title":"Activation of oncogenic pathways in degenerating neurons in Alzheimer disease","volume":"18","author":"Zhu","year":"2000","journal-title":"Int J Dev Neurosci"},{"key":"10.3233\/JAD-143210_ref31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12035-009-8095-7","article-title":"Abnormal mitochondrial dynamics\u2013a novel therapeutic targetfor Alzheimer\u2019s disease?","volume":"41","author":"Su","year":"2010","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-143210_ref32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.18632\/aging.100044","article-title":"Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease","volume":"1","author":"Bonda","year":"2009","journal-title":"Aging"},{"key":"10.3233\/JAD-143210_ref33","first-page":"134","article-title":"Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease","volume":"1","author":"Thakur","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"10.3233\/JAD-143210_ref34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1091\/mbc.e09-10-0850","article-title":"Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21; requirement for tau and APP","volume":"21","author":"Granic","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.3233\/JAD-143210_ref35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neurobiolaging.2006.10.027","article-title":"Alzheimer\u2019s presenilin 1 causes chromosome missegregation and aneuploidy","volume":"29","author":"Boeras","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/nbdi.1999.0236","article-title":"Chromosome missegregation and trisomy 21 mosaicism in Alzheimer\u2019s disease","volume":"6","author":"Geller","year":"1999","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-143210_ref37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-7091-6139-5_8","article-title":"Dysregulation of neuronal differentiation and cell cycle control in Alzheimer\u2019s disease","author":"Arendt","year":"2002","journal-title":"J Neural Transm Suppl"},{"key":"10.3233\/JAD-143210_ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3233\/JAD-2002-4316","article-title":"Cell cycle proteins in Alzheimer\u2019s disease: Plenty of wheels but no cycle","volume":"4","author":"Bowser","year":"2002","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2990.2010.01064.x","article-title":"Cell cycle aberrations and neurodegeneration: A review","volume":"36","author":"Bonda","year":"2010","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-143210_ref40","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1523\/JNEUROSCI.2441-08.2008","article-title":"Abeta oligomers induce neuronal cell cycleevents in Alzheimer\u2019s disease","volume":"28","author":"Varvel","year":"2008","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bbadis.2006.11.001","article-title":"The dysregulation of the cell cycle and the diagnosis of Alzheimer\u2019s disease","volume":"1772","author":"Nagy","year":"2007","journal-title":"Biochim BiophysActa"},{"key":"10.3233\/JAD-143210_ref42","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1523\/JNEUROSCI.23-07-02557.2003","article-title":"Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer\u2019s disease","volume":"23","author":"Yang","year":"2003","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref43","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1523\/JNEUROSCI.18-08-02801.1998","article-title":"Ectopic cell cycle proteins predict the sites of neuronal cell death inAlzheimer\u2019s disease brain","volume":"18","author":"Busser","year":"1998","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0197-4580(98)00071-2","article-title":"Mitotic phosphoepitopes precede paired helical filaments in Alzheimer\u2019s disease","volume":"19","author":"Vincent","year":"1998","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.1993.tb23035.x","article-title":"Regulation and expression of the Alzheimer\u2019s beta\/A4 amyloid protein precursor in health, disease, and Down\u2019s syndrome","volume":"695","author":"Beyreuther","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"10.3233\/JAD-143210_ref46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jexbot\/52.355.183","article-title":"Investigating the hows and whys of DNA endoreduplication","volume":"52","author":"Larkins","year":"2001","journal-title":"J Exp Bot"},{"key":"10.3233\/JAD-143210_ref47","first-page":"227","article-title":"Nucleotype and cell size in vertebrates: A review","volume":"27","author":"Olmo","year":"1983","journal-title":"Basic Appl Histochem"},{"key":"10.3233\/JAD-143210_ref48","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.neurobiolaging.2007.05.005","article-title":"Resistance to Alzheimer\u2019s pathology is associated with nuclear hypertrophy in neurons","volume":"28","author":"Riudavets","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref49","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/NEN.0b013e3181772794","article-title":"Neuronal hypertrophy in asymptomatic Alzheimer disease","volume":"67","author":"Iacono","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-143210_ref50","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1212\/WNL.0b013e3181b01077","article-title":"The Nun study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life","volume":"73","author":"Iacono","year":"2009","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref51","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3233\/JAD-2009-1179","article-title":"Neuropathologic studies of the Baltimore Longitudinal Studyof Aging (BLSA)","volume":"18","author":"O\u2019Brien","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref52","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2004.09.008","article-title":"Tau pathology in Alzheimer disease and other tauopathies","volume":"1739","author":"Iqbal","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-143210_ref53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00018-004-4381-3","article-title":"The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain","volume":"62","author":"Vadakkadath Meethal","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.3233\/JAD-143210_ref54","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1523\/JNEUROSCI.0186-07.2007","article-title":"Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice","volume":"27","author":"Park","year":"2007","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref55","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbadis.2006.09.010","article-title":"Neuronal cell cycle re-entry mediates Alzheimer disease-type changes","volume":"1772","author":"McShea","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-143210_ref56","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0387-7604(12)80066-0","article-title":"Developmental and aging changes in the expression patterns of beta-amyloid in the brains of normal and Down syndrome cases","volume":"12","author":"Takashima","year":"1990","journal-title":"Brain Dev"},{"key":"10.3233\/JAD-143210_ref57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00005072-199701000-00004","article-title":"Developmental regulation of presenilin mRNA expression parallels notch expression","volume":"56","author":"Berezovska","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-143210_ref58","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0955-0674(97)80082-8","article-title":"The mechanism and control of cytokinesis","volume":"9","author":"Glotzer","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.3233\/JAD-143210_ref59","first-page":"431","article-title":"The mitotic checkpoint: A signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit","volume":"5","author":"Chan","year":"2003","journal-title":"Prog Cell Cycle Res"},{"key":"10.3233\/JAD-143210_ref60","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1126\/science.1248903","article-title":"Hippocampal neurogenesis regulatesforgetting during adulthood and infancy","volume":"344","author":"Akers","year":"2014","journal-title":"Science"},{"key":"10.3233\/JAD-143210_ref61","doi-asserted-by":"crossref","first-page":"23806","DOI":"10.1074\/jbc.M109.026328","article-title":"Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells","volume":"284","author":"Porayette","year":"2009","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref62","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bbrc.2007.10.021","article-title":"Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: A novel role for human chorionic gonadotropin","volume":"364","author":"Porayette","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-143210_ref63","doi-asserted-by":"crossref","first-page":"24264","DOI":"10.1074\/jbc.M111.227421","article-title":"Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells","volume":"286","author":"Freude","year":"2011","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm0197-67","article-title":"Mutant presenilins of Alzheimer\u2019s disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice","volume":"3","author":"Citron","year":"1997","journal-title":"Nat Med"},{"key":"10.3233\/JAD-143210_ref65","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1523\/JNEUROSCI.23-17-06914.2003","article-title":"DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3","volume":"23","author":"McPhie","year":"2003","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref66","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1242\/jcs.1125880","article-title":"Amyloid-beta signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer\u2019s disease","volume":"126","author":"Seward","year":"2013","journal-title":"J Cell Sci"},{"key":"10.3233\/JAD-143210_ref67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0169-328X(01)00294-7","article-title":"beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer\u2019s disease mutations","volume":"97","author":"McPhie","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.3233\/JAD-143210_ref68","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.272.5266.1349","article-title":"G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer\u2019s disease-associated mutants of APP","volume":"272","author":"Yamatsuji","year":"1996","journal-title":"Science"},{"key":"10.3233\/JAD-143210_ref69","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/j.1460-2075.1996.tb00382.x","article-title":"Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype","volume":"15","author":"Yamatsuji","year":"1996","journal-title":"EMBO J"},{"key":"10.3233\/JAD-143210_ref70","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/jnr.21690","article-title":"Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo","volume":"86","author":"Ahn","year":"2008","journal-title":"J\u00a0Neurosci Res"},{"key":"10.3233\/JAD-143210_ref71","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/383710a0","article-title":"Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1","volume":"383","author":"Duff","year":"1996","journal-title":"Nature"},{"key":"10.3233\/JAD-143210_ref72","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1523\/JNEUROSCI.19-11-04229.1999","article-title":"Presenilin 1 facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer\u2019s disease-linked PS1 mutants in the beta-catenin-signaling pathway","volume":"19","author":"Kang","year":"1999","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref73","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.152.4.785","article-title":"Presenilin 1 negatively regulates beta-catenin\/T cell factor\/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing","volume":"152","author":"Soriano","year":"2001","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-143210_ref74","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0002-9440(10)62962-8","article-title":"Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation","volume":"167","author":"Chevallier","year":"2005","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-143210_ref75","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1523\/JNEUROSCI.0527-10.2010","article-title":"Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling","volume":"30","author":"Veeraraghavalu","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref76","doi-asserted-by":"crossref","first-page":"637","DOI":"10.4161\/cc.7.5.5427","article-title":"Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer\u2019s disease brain","volume":"7","author":"Malik","year":"2008","journal-title":"Cell Cycle"},{"key":"10.3233\/JAD-143210_ref77","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","article-title":"Familial Alzheimer\u2019s disease-linked presenilin 1 variants elevate Abeta1-42\/1-40 ratio in vitro and in vivo","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"10.3233\/JAD-143210_ref78","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0002-9440(10)65108-5","article-title":"Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer\u2019s disease PS2(N141I)mutant","volume":"155","author":"Janicki","year":"1999","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-143210_ref79","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0197-4580(00)00222-0","article-title":"Familial Alzheimer\u2019s disease presenilin-1 mutants potentiate cell cycle arrest","volume":"21","author":"Janicki","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref80","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0969-9961(03)00040-8","article-title":"Ca2+\/calmodulin-dependent modulation of cell cycle elements pRb and p27kip1 involved in the enhanced proliferation of lymphoblasts from patients with Alzheimer dementia","volume":"13","author":"de las Cuevas","year":"2003","journal-title":"Neurobiol Dis"},{"issue":"2319","key":"10.3233\/JAD-143210_ref81","first-page":"e2313","article-title":"Cell cycle regulation distinguishes lymphocytes from sporadic and familial Alzheimer\u2019s disease patients","volume":"32","author":"Bialopiotrowicz","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref82","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neulet.2012.03.093","article-title":"Combination of p53(ser15) and p21\/p21(thr145) in peripheral blood lymphocytes as potential Alzheimer\u2019s disease biomarkers","volume":"516","author":"Tan","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-143210_ref83","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neulet.2009.11.024","article-title":"P53-mediated G(1)\/S checkpoint dysfunction in lymphocytes from Alzheimer\u2019s disease patients","volume":"468","author":"Zhou","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-143210_ref84","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.2174\/138161208786264133","article-title":"Pharmacogenetics andpharmagenomics, trends in normal and pathological aging studies: Focus on p53","volume":"14","author":"Lanni","year":"2008","journal-title":"Curr Pharm Design"},{"key":"10.3233\/JAD-143210_ref85","doi-asserted-by":"crossref","first-page":"23806","DOI":"10.1074\/jbc.M109.026328","article-title":"Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells","volume":"284","author":"Porayette","year":"2009","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref86","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bbrc.2007.10.021","article-title":"Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: A novel role for human chorionic gonadotropin","volume":"364","author":"Porayette","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-143210_ref87","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1523\/JNEUROSCI.23-13-05531.2003","article-title":"The production of amyloid beta peptide is a critical requirement for the viability of central neurons","volume":"23","author":"Plant","year":"2003","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref88","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.0403678101","article-title":"Enhanced neurogenesis in Alzheimer\u2019s disease transgenic (PDGF-APPSw, Ind) mice","volume":"101","author":"Jin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-143210_ref89","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1523\/JNEUROSCI.0974-04.2004","article-title":"Neurogenic effect of beta-amyloid peptide in the development of neural stem cells","volume":"24","author":"Lopez-Toledano","year":"2004","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref90","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.neurobiolaging.2005.03.019","article-title":"Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid","volume":"27","author":"Calafiore","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref91","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1471-4159.2007.04499.x","article-title":"Effects of the monomeric,oligomeric, and fibrillar Abeta42 peptides on the proliferation and differentiation of adult neural stem cellsfrom subventricular zone","volume":"102","author":"Heo","year":"2007","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-143210_ref92","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.neurobiolaging.2008.02.004","article-title":"Abeta(1-42) stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor","volume":"30","author":"Sotthibundhu","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref93","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0002-9440(10)63185-9","article-title":"Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities","volume":"164","author":"Jin","year":"2004","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-143210_ref94","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/cne.20840","article-title":"Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer\u2019s disease","volume":"495","author":"Donovan","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.3233\/JAD-143210_ref95","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.nbd.2007.08.002","article-title":"Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer\u2019s disease-like transgenic (pPDGF-APPSw, Ind) mice","volume":"29","author":"Gan","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-143210_ref96","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3233\/JAD-2007-12304","article-title":"Increased neurogenesis in young transgenic mice overexpressing human APP(Sw, Ind)","volume":"12","author":"Lopez-Toledano","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref97","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.2353\/ajpath.2008.060520","article-title":"Neurogenesis andalterations of neural stem cells in mouse models of cerebral amyloidosis","volume":"172","author":"Ermini","year":"2008","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-143210_ref98","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jnen\/64.2.93","article-title":"Dysregulation of\u00a0thehypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence","volume":"64","author":"Atwood","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-143210_ref99","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1586\/14737159.9.1.51","article-title":"Human chorionic gonadotropin and associated molecules","volume":"9","author":"Cole","year":"2009","journal-title":"Exp Rev Mol Diagn"},{"key":"10.3233\/JAD-143210_ref100","first-page":"22","article-title":"HCG variants, the growth factors which drive human malignancies","volume":"2","author":"Cole","year":"2012","journal-title":"Am J Cancer Res"},{"key":"10.3233\/JAD-143210_ref101","doi-asserted-by":"crossref","first-page":"20539","DOI":"10.1074\/jbc.M311993200","article-title":"Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition","volume":"279","author":"Bowen","year":"2004","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref102","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s10571-013-9954-3","article-title":"Human chorionic gonadotropin increases beta-cleavage of amyloid precursor protein in SH-SY5Y cells","volume":"33","author":"Saberi","year":"2013","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-143210_ref103","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nm0498-447","article-title":"Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides","volume":"4","author":"Xu","year":"1998","journal-title":"Nat Med"},{"key":"10.3233\/JAD-143210_ref104","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1073\/pnas.97.3.1202","article-title":"Testosterone reduces neuronal secretion of Alzheimer\u2019s beta-amyloid peptides","volume":"97","author":"Gouras","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-143210_ref105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yfrne.2009.04.015","article-title":"Protective actions of sex steroid hormones in Alzheimer\u2019s disease","volume":"30","author":"Pike","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"10.3233\/JAD-143210_ref106","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.yhbeh.2008.02.006","article-title":"Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-beta levels in female rats","volume":"54","author":"Berry","year":"2008","journal-title":"Horm Behav"},{"key":"10.3233\/JAD-143210_ref107","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000330812","article-title":"Direct exposure of guinea pig CNS to human luteinizing hormone increases cerebrospinal fluid andcerebral beta amyloid levels","volume":"94","author":"Wahjoepramono","year":"2011","journal-title":"Neuroendocrinology"},{"key":"10.3233\/JAD-143210_ref108","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/NEN.0b013e3181d072cf","article-title":"Genetic ablation of luteinizing hormone receptorimproves the amyloid pathology in a mouse model of Alzheimer disease","volume":"69","author":"Lin","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-143210_ref109","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neurobiolaging.2008.03.027","article-title":"Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer\u2019s disease inpatients with mild cognitive impairment","volume":"31","author":"Hansson","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref110","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1523\/JNEUROSCI.23-07-02557.2003","article-title":"Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer\u2019s disease","volume":"23","author":"Yang","year":"2003","journal-title":"J Neuosci"},{"key":"10.3233\/JAD-143210_ref111","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3233\/JAD-2008-14208","article-title":"Luteinizing hormone levels are positively correlated with plasmaamyloid-beta protein levels in elderly men","volume":"14","author":"Verdile","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref112","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/mp.2012.147","article-title":"Associations between gonadotropins, testosterone and beta amyloid in men at risk of Alzheimer\u2019s disease","volume":"19","author":"Verdile","year":"2014","journal-title":"Mol Psychiatry"},{"key":"10.3233\/JAD-143210_ref113","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1124\/pr.112.005850","article-title":"Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer\u2019s disease links numerous treatment rationales","volume":"64","author":"Clark","year":"2012","journal-title":"Pharmacol Rev"},{"key":"10.3233\/JAD-143210_ref114","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2011-110887","article-title":"Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer\u2019s disease?","volume":"27","author":"Clark","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref115","first-page":"83","article-title":"Cell cycle-specific effects of tumor necrosis factor","volume":"44","author":"Darzynkiewicz","year":"1984","journal-title":"Cancer Res"},{"key":"10.3233\/JAD-143210_ref116","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/WAD.0b013e318258cd63","article-title":"Male sex hormones and systemic inflammation in Alzheimer disease","volume":"27","author":"Butchart","year":"2013","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"Suppl","key":"10.3233\/JAD-143210_ref117","doi-asserted-by":"crossref","first-page":"S462","DOI":"10.1016\/j.jalz.2006.05.1565","article-title":"Luteinizing hormone mediates Alzheimer-type changes in neurons","volume":"2","author":"Casadesus","year":"2006","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-143210_ref118","first-page":"1465","article-title":"Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5","volume":"147","author":"Brion","year":"1995","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-143210_ref119","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0306-4522(94)90533-9","article-title":"Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons","volume":"63","author":"Brion","year":"1994","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-143210_ref120","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1471-4159.1992.tb10039.x","article-title":"Fetal-type phosphorylation of the tau in paired helical filaments","volume":"58","author":"Kanemaru","year":"1992","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-143210_ref121","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/exnr.1994.1057","article-title":"Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y","volume":"126","author":"Pope","year":"1994","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-143210_ref122","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0306-4522(95)00146-A","article-title":"Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer\u2019s disease","volume":"68","author":"Arendt","year":"1995","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-143210_ref123","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1097\/00001756-199611250-00050","article-title":"Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer\u2019s disease","volume":"7","author":"Arendt","year":"1996","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-143210_ref124","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1083\/jcb.132.3.413","article-title":"Mitotic mechanisms in Alzheimer\u2019s disease?","volume":"132","author":"Vincent","year":"1996","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-143210_ref125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s004010050665","article-title":"Cell cycle markers in the hippocampus in Alzheimer\u2019s disease","volume":"94","author":"Nagy","year":"1997","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-143210_ref126","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3233\/JAD-2004-6610","article-title":"Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3","volume":"6","author":"Lovell","year":"2004","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref127","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fneur.2013.00161","article-title":"Tau in MAPK activation","volume":"4","author":"Leugers","year":"2013","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-143210_ref128","doi-asserted-by":"crossref","first-page":"19125","DOI":"10.1074\/jbc.M110.105387","article-title":"Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding","volume":"285","author":"Leugers","year":"2010","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref129","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/j.1939-4640.2000.tb03393.x","article-title":"Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines","volume":"21","author":"Musa","year":"2000","journal-title":"J Androl"},{"key":"10.3233\/JAD-143210_ref130","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1523\/JNEUROSCI.1773-05.2005","article-title":"Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation","volume":"25","author":"Cicero","year":"2005","journal-title":"J\u00a0Neurosci"},{"key":"10.3233\/JAD-143210_ref131","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.4161\/cc.7.22.7045","article-title":"Cdk5 and the non-catalytic arrest of the neuronal cell cycle","volume":"7","author":"Zhang","year":"2008","journal-title":"Cell Cycle"},{"key":"10.3233\/JAD-143210_ref132","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1101\/gad.10.7.816","article-title":"The cdk5\/p35 kinase is essential for neurite outgrowthduring neuronal differentiation","volume":"10","author":"Nikolic","year":"1996","journal-title":"Genes Dev"},{"key":"10.3233\/JAD-143210_ref133","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.4161\/cc.10.8.15328","article-title":"Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons","volume":"10","author":"Zhang","year":"2011","journal-title":"Cell Cycle"},{"key":"10.3233\/JAD-143210_ref134","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.5628-09.2010","article-title":"Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex","volume":"30","author":"Zhang","year":"2010","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref135","doi-asserted-by":"crossref","first-page":"14052","DOI":"10.1074\/jbc.M109.068262","article-title":"Cdk5 nuclear localization is p27-dependent in nerve cells: Implications for cell cycle suppression and caspase-3 activation","volume":"285","author":"Zhang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref136","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1523\/JNEUROSCI.2899-05.2005","article-title":"Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronaldeath","volume":"25","author":"O\u2019Hare","year":"2005","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref137","doi-asserted-by":"crossref","first-page":"14052","DOI":"10.1074\/jbc.M109.068262","article-title":"Cdk5 nuclear localization is p27-dependent in nerve cells: Implications for cell cycle suppression and caspase-3 activation","volume":"285","author":"Zhang","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-143210_ref138","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.5628-09.2010","article-title":"Cdk5 suppresses the neuronal cell cycle bydisrupting the E2F1-DP1 complex","volume":"30","author":"Zhang","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref139","doi-asserted-by":"crossref","first-page":"E4887","DOI":"10.1073\/pnas.1402627111","article-title":"CDK5 activator protein p25 preferentially binds and activates GSK3beta","volume":"111","author":"Chow","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-143210_ref140","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1210\/me.2007-0457","article-title":"Luteinizing hormone receptor activation in ovarian granulosa cells promotes protein kinase A-dependent dephosphorylation of microtubule-associated protein 2D","volume":"22","author":"Flynn","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.3233\/JAD-143210_ref141","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1460-9568.2007.05618.x","article-title":"Abeta treatment and P301L tau expression in an Alzheimer\u2019s disease tissue culture model act synergistically to promote aberrant cell cycle re-entry","volume":"26","author":"Hoerndli","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.3233\/JAD-143210_ref142","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10571-007-9224-3","article-title":"Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: Implications for Alzheimer\u2019s disease and prion-related encephalopathies","volume":"27","author":"Lopes","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-143210_ref143","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4161\/cc.8.1.7506","article-title":"Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides","volume":"8","author":"Lopes","year":"2009","journal-title":"Cell Cycle"},{"key":"10.3233\/JAD-143210_ref144","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10571-007-9224-3","article-title":"Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: Implications for Alzheimer\u2019s disease and prion-related encephalopathies","volume":"27","author":"Lopes","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-143210_ref145","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1474-9726.2009.00536.x","article-title":"Neurodegeneration in an Abeta-induced model of Alzheimer\u2019s disease: The role of Cdk5","volume":"9","author":"Lopes","journal-title":"Aging Cell"},{"key":"10.3233\/JAD-143210_ref146","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3233\/JAD-2009-0993","article-title":"Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology","volume":"16","author":"Lopes","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref147","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neurobiolaging.2014.09.025","article-title":"Advancedglycation end products are mitogenic signals and trigger cellcycle re-entry of neurons in Alzheimer\u2019s disease brain","volume":"36","author":"Kuhla","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-143210_ref148","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/gme.0b013e3181e170af","article-title":"Androgens associated with advanced glycation end-products in postmenopausal women","volume":"17","author":"Diamanti-Kandarakis","year":"2010","journal-title":"Menopause"},{"key":"10.3233\/JAD-143210_ref149","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2265.2004.02170.x","article-title":"Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome","volume":"62","author":"Diamanti-Kandarakis","year":"2005","journal-title":"Clin Endocrinol"},{"key":"10.3233\/JAD-143210_ref150","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.3233\/JAD-143210_ref151","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.3233\/JAD-143210_ref152","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1126\/science.1971458","article-title":"Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)","volume":"248","author":"Van Broeckhoven","year":"1990","journal-title":"Science"},{"key":"10.3233\/JAD-143210_ref153","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.2111584","article-title":"Mutation of the Alzheimer\u2019s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type","volume":"248","author":"Levy","year":"1990","journal-title":"Science"},{"key":"10.3233\/JAD-143210_ref154","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0304-3940(94)90463-4","article-title":"Amyloid precursor protein mutation causes Alzheimer\u2019s disease in a Swedish family","volume":"168","author":"Lannfelt","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-143210_ref155","first-page":"2545","article-title":"\u201cAdd-back\u201d estrogen reverses cognitive deficits induced by a gonadotropin-releasing hormone agonist in women with leiomyomata uteri","volume":"81","author":"Sherwin","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3233\/JAD-143210_ref156","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1212\/01.wnl.0000276984.19542.e6","article-title":"Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause","volume":"69","author":"Rocca","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref157","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00018-004-4385-z","article-title":"Neuroprotective effects of female sex steroids in humans: Current controversies and future directions","volume":"62","author":"Gleason","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.3233\/JAD-143210_ref158","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1600-0447.1987.tb02906.x","article-title":"The prevalence of dementia: A quantitative integration of the literature","volume":"76","author":"Jorm","year":"1987","journal-title":"Acta Psychiatr Scand"},{"key":"10.3233\/JAD-143210_ref159","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1136\/bmj.306.6879.680","article-title":"Epidemiology of Alzheimer\u2019s preseniledementia in Scotland, 1974-88","volume":"306","author":"McGonigal","year":"1993","journal-title":"BMJ"},{"key":"10.3233\/JAD-143210_ref160","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","article-title":"Projections of Alzheimer\u2019s disease in the United States and the public health impact of delaying disease onset","volume":"88","author":"Brookmeyer","year":"1998","journal-title":"Am J Public Health"},{"key":"10.3233\/JAD-143210_ref161","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archpsyc.55.9.809","article-title":"The relationships between age, sex, and the incidence of dementia and Alzheimer disease: A meta-analysis","volume":"55","author":"Gao","year":"1998","journal-title":"Arch Gen Psychiatry"},{"key":"10.3233\/JAD-143210_ref162","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1212\/WNL.53.9.1992","article-title":"Gender differences in the incidence of AD andvascular dementia: The EURODEM Studies. EURODEM Incidence Research Group","volume":"53","author":"Andersen","year":"1999","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref163","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/WNL.55.2.198","article-title":"Prevalence of AD among whites: A summary by levels of severity","volume":"55","author":"Hy","year":"2000","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref164","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1212\/WNL.54.4.833","article-title":"Endogenous estrogen levels and Alzheimer\u2019s disease among postmenopausal women","volume":"54","author":"Manly","year":"2000","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref165","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1365-2826.2000.00461.x","article-title":"An association of elevated serum gonadotropin concentrations and Alzheimer disease?","volume":"12","author":"Bowen","year":"2000","journal-title":"J Neuroendocrinol"},{"key":"10.3233\/JAD-143210_ref166","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.exger.2004.06.019","article-title":"Low free testosterone is an independent risk factor for Alzheimer\u2019s disease","volume":"39","author":"Hogervorst","year":"2004","journal-title":"Exp Gerontol"},{"key":"10.3233\/JAD-143210_ref167","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0025-6196(11)62109-5","article-title":"Elevated gonadotropin levels in patients with Alzheimer disease","volume":"76","author":"Short","year":"2001","journal-title":"Mayo Clin Proc"},{"key":"10.3233\/JAD-143210_ref168","first-page":"163","article-title":"Serum total testosterone is lower in men with Alzheimer\u2019s disease","volume":"22","author":"Hogervorst","year":"2001","journal-title":"Neuroendocrinol Lett"},{"key":"10.3233\/JAD-143210_ref169","first-page":"203","article-title":"Testosterone and gonadotropin levels in men with dementia","volume":"24","author":"Hogervorst","year":"2003","journal-title":"Neuro Endocrinol Lett"},{"key":"10.3233\/JAD-143210_ref170","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/JAD-2008-13304","article-title":"Gonadotropins and cognition in older women","volume":"13","author":"Rodrigues","year":"2008","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref171","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3233\/JAD-2010-1342","article-title":"Higher luteinizing hormone is associated with poor memory recall: The health in men study","volume":"19","author":"Hyde","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref172","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/WAD.0b013e31819cb8f4","article-title":"Luteinizing-hormone releasing hormone therapy and the risk of death from Alzheimer disease","volume":"24","author":"D\u2019Amico","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-143210_ref173","first-page":"17","article-title":"Late Breaking Abstract: Men treated for prostate cancer have a decreased incidence of dementia","author":"Bowen","year":"2004","journal-title":"9th International Conference on Alzheimer\u2019s Disease and Related Disorders"},{"key":"10.3233\/JAD-143210_ref174","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.purol.2008.09.056","article-title":"Effects by androgen suppression with luteinizing hormone on cognitive functions in men treated for cancer of prostate","volume":"19","author":"Nedelec","year":"2009","journal-title":"Prog Urol"},{"key":"10.3233\/JAD-143210_ref175","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3233\/JAD-141626","article-title":"A clinical study of lupron depot in the treatment of women with Alzheimer\u2019s disease: Preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks","volume":"44","author":"Bowen","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref176","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000079125","article-title":"Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones","volume":"50","author":"Bowen","year":"2004","journal-title":"Gerontology"},{"key":"10.3233\/JAD-143210_ref177","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.4946-04.2005","article-title":"Loss of neuronal cell cycle control in ataxia-telangiectasia: A unified disease mechanism","volume":"25","author":"Yang","year":"2005","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-143210_ref178","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.exger.2003.08.005","article-title":"Pennington scientific symposium on mechanisms and retardation of aging","volume":"38","author":"Atwood","year":"2003","journal-title":"Exp Gerontol"},{"key":"10.3233\/JAD-143210_ref179","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/tam.6.1.13.17","article-title":"A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer\u2019s disease","volume":"6","author":"Tan","year":"2003","journal-title":"Aging Male"},{"key":"10.3233\/JAD-143210_ref180","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/01.WNL.0000165995.98986.F1","article-title":"Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment","volume":"64","author":"Cherrier","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref181","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0306-4530(99)00020-7","article-title":"Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer\u2019s disease: Results of a placebo-controlled, double-blind, pilot study","volume":"24","author":"Asthana","year":"1999","journal-title":"Psychoneuroendocrinology"},{"key":"10.3233\/JAD-143210_ref182","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1212\/WNL.57.4.605","article-title":"High-dose estradiol improves cognition for women with AD: Results of a randomized study","volume":"57","author":"Asthana","year":"2001","journal-title":"Neurology"},{"key":"10.3233\/JAD-143210_ref183","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3233\/JAD-2011-110341","article-title":"Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer\u2019s disease: Results of a randomized controlled trial","volume":"26","author":"Wharton","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-143210_ref186","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1217697","article-title":"ApoE-directed therapeutics rapidly clearbeta-amyloid and reverse deficits in AD mouse models","volume":"335","author":"Cramer","year":"2012","journal-title":"Science"},{"key":"10.3233\/JAD-143210_ref187","first-page":"3692","article-title":"NSAIDs prevent, but do not reverse, neuronal cellcycle re-entry in a mouse model of Alzheimer disease","volume":"119","author":"Varvel","year":"2009","journal-title":"J ClinInvest"},{"key":"10.3233\/JAD-143210_ref188","first-page":"115","article-title":"Amyloid-\u03b2 aggregation as a protectiveacute-phase response to injury\/neurodegeneration: A barrierfunction for amyloid-\u03b2 deposits","author":"Atwood","year":"2010","journal-title":"In FunctionalAmyloid Aggregation"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-143210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:27Z","timestamp":1777370547000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-143210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":184,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-143210","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]}}}