{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:34:36Z","timestamp":1777394076260,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2015,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Four previously reported studies have tested for association of\n          blood proteins with neocortical amyloid-\u03b2 burden (NAB). If shown to be robust, these\n          proteins could have utility as a blood test for enrichment in clinical trials of\n          Alzheimer\u2019s disease (AD) therapeutics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aimed to investigate whether previously identified\n          blood proteins also show evidence for association with NAB in serum samples from the\n          Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL). The study\n          considers candidate proteins seen in cohorts other than AIBL and candidates previously\n          discovered in the AIBL cohort.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Our study used the SOMAscan platform for protein quantification in\n          blood serum. Linear and logistic regressions were used to model continuous NAB and\n          dichotomized NAB respectively using single proteins as a predictor. Multiple protein\n          models were built using stepwise regression techniques and support vectors machines. Age\n          and\n                    <jats:italic>APOE<\/jats:italic>\n                    <jats:italic>\u025b<\/jats:italic>\n                    4 carriage were used as covariates for all analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Of the 41 proteins previously reported, 15 AIBL candidates and 20\n          non-AIBL candidates were available for testing. Of these candidates, pancreatic\n          polypeptide (PPY) and IgM showed a significant association with NAB. Notably, IgM was\n          found to associate with continuous NAB across cognitively normal control subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    We have further demonstrated the association of PPY and IgM\n          with NAB, despite technical differences between studies. There are several reasons for a\n          lack of significance for the other candidates including platform differences and the use\n          of serum rather than plasma samples. To investigate the possibility of technical\n          differences causing lack of replication, further studies are required.\n                  <\/jats:p>","DOI":"10.3233\/jad-150020","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T11:52:04Z","timestamp":1435751524000},"page":"947-961","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Blood Protein Markers of Neocortical Amyloid-\u03b2 Burden: A Candidate Study          Using SOMAscan Technology"],"prefix":"10.1177","volume":"46","author":[{"given":"Nicola","family":"Voyle","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s\r          College London, London, UK"},{"name":"MRC Social, Genetic and Developmental Psychiatry Centre,\r          King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[{"name":"Janssen R&amp;D, Neurosciences, Titusville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha C.","family":"Burnham","sequence":"additional","affiliation":[{"name":"CSIRO Digital Productivity and Food and Nutrition Flagships:\r          eHealth, Floreat, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Covin","sequence":"additional","affiliation":[{"name":"Janssen R&amp;D, Neurosciences, Titusville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanpan","family":"Zhang","sequence":"additional","affiliation":[{"name":"GE Global Research, Niskayuna, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipen P.","family":"Sangurdekar","sequence":"additional","affiliation":[{"name":"GE Global Research, Niskayuna, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina A.","family":"Tan Hehir","sequence":"additional","affiliation":[{"name":"GE Global Research, Niskayuna, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Bazenet","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s\r          College London, London, UK"},{"name":"NIHR Biomedical Research Centre for Mental Health and\r          Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London,\r          UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Lovestone","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s\r          College London, London, UK"},{"name":"Department of Psychiatry, Oxford University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kiddle","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s\r          College London, London, UK"},{"name":"MRC Social, Genetic and Developmental Psychiatry Centre,\r          King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.B.","family":"Dobson","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s\r          College London, London, UK"},{"name":"NIHR Biomedical Research Centre for Mental Health and\r          Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London,\r          UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"and the AIBL research group h","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Querfurth H LaFerla F (2011) (2010) Alzheimer\u2019s disease. 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