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Analysis of activity in 12-12\u200ah lighting or constant darkness showed only minor differences between AD-Tg and non-Tg mice. Jet lag greatly reduced activity in both genotypes during the normal dark time. Learning on the Morris water maze was significantly impaired only in the AD-Tg mice exposed to jet lag. However, memory 3 days after training was impaired in both genotypes. Jet lag caused a decrease of glutathione (GSH) levels that tended to be more pronounced in AD-Tg than in non-Tg brains and an associated increase in NADH levels in both genotypes. Lower brain GSH levels after jet lag correlated with poor performance on the maze. These data indicate that the combination of the environmental stress of circadian disruption together with latent stress of the mutant amyloid and NOS2 knockout contributes to cognitive deficits that correlate with lower GSH levels.<\/jats:p>","DOI":"10.3233\/jad-150026","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T08:35:18Z","timestamp":1448613318000},"page":"301-316","source":"Crossref","is-referenced-by-count":15,"title":["Circadian Disruption Reveals a Correlation of an Oxidative GSH\/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer\u2019s Disease Mouse Model"],"prefix":"10.1177","volume":"49","author":[{"given":"Kelsey R.","family":"LeVault","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School Medicine, Springfield, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley 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