{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:58:29Z","timestamp":1792699109626,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2015,8,28]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:bold>\n The cerebrospinal fluid (CSF) amyloid-\u03b2 (A\u03b2)\n 1-42<\/jats:sub>\n ,\n total-tau (T-tau), and phosphorylated-tau (P-tau\n 181P<\/jats:sub>\n ) profile has been\n established as a valuable biomarker for Alzheimer\u2019s disease (AD).\n <\/jats:p>\n \n Objective:<\/jats:bold>\n The current study aimed to determine CSF biomarker cut-points\n using positron emission tomography (PET) A\u03b2 imaging screened subjects from the Australian\n Imaging, Biomarkers and Lifestyle (AIBL) study of aging, as well as correlate CSF analyte\n cut-points across a range of PET A\u03b2 amyloid ligands.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n A\u03b2 pathology was determined by PET imaging, utilizing\n 11<\/jats:sup>\n C-Pittsburgh Compound B,\n 18<\/jats:sup>\n F-flutemetamol, or\n 18<\/jats:sup>\n F-florbetapir, in 157 AIBL participants who also underwent CSF collection.\n Using an INNOTEST assay, cut-points were established (A\u03b2\n 1-42<\/jats:sub>\n >544\u200ang\/L,\n T-tau <407\u200ang\/L, and P-tau\n 181P<\/jats:sub>\n <78\u200ang\/L) employing a rank based method to\n define a \u201cpositive\u201d CSF in the sub-cohort of amyloid-PET negative healthy participants\n (\n n<\/jats:italic>\n \u200a=\u200a97), and compared with the presence of PET demonstrated AD\n pathology.\n <\/jats:p>\n \n Results:<\/jats:bold>\n CSF A\u03b2\n 1-42<\/jats:sub>\n was the strongest individual biomarker,\n detecting cognitively impaired PET positive mild cognitive impairment (MCI)\/AD with 85%\n sensitivity and 91% specificity. The ratio of P-tau\n 181P<\/jats:sub>\n or T-tau to\n A\u03b2\n 1-42<\/jats:sub>\n provided greater accuracy, predicting MCI\/AD with A\u03b2 pathology with\n \u226592% sensitivity and specificity. Cross-validated accuracy, using all three biomarkers or\n the ratio of P-tau or T-tau to A\u03b2\n 1-42<\/jats:sub>\n to predict MCI\/AD, reached \u226592%\n sensitivity and specificity.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n CSF A\u03b2\n 1-42<\/jats:sub>\n levels and analyte combination ratios\n demonstrated very high correlation with PET A\u03b2 imaging. Our study offers additional\n support for CSF biomarkers in the early and accurate detection of AD pathology, including\n enrichment of patient cohorts for treatment trials even at the pre-symptomatic stage.\n <\/jats:p>","DOI":"10.3233\/jad-150247","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T17:47:02Z","timestamp":1441216022000},"page":"175-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Alzheimer\u2019s Disease Normative Cerebrospinal Fluid Biomarkers Validated in\u00a0PET Amyloid-\u03b2 Characterized Subjects from the Australian Imaging, Biomarkers and\u00a0Lifestyle (AIBL) study"],"prefix":"10.1177","volume":"48","author":[{"given":"Qiao-Xin","family":"Li","sequence":"first","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"},{"name":"Department of Nuclear Medicine and Centre for PET, Austin\r Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Doecke","sequence":"additional","affiliation":[{"name":"CSIRO Digital Productivity\/Australian e-Health Research\r Centre and Cooperative Research Centre for Mental Health, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Rembach","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Sarros","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiji","family":"Varghese","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"McGlade","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Laughton","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly K.","family":"Pertile","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Rumble","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett O.","family":"Trounson","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research &\r Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia,\r Australia"},{"name":"Sir James McCusker Alzheimer\u2019s Disease Research Unit\r (Hollywood Private Hospital), Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Rainey-Smith","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research &\r Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia,\r Australia"},{"name":"Sir James McCusker Alzheimer\u2019s Disease Research Unit\r (Hollywood Private Hospital), Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u00a0M.","family":"Laws","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research &\r Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia,\r Australia"},{"name":"Sir James McCusker Alzheimer\u2019s Disease Research Unit\r (Hollywood Private Hospital), Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne S.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth A.","family":"Evered","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesia and Cognitive Function, Department of\r Anaesthesia, and Department of Surgery, St. Vincent\u2019s Hospital, The University of\r Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Silbert","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesia and Cognitive Function, Department of\r Anaesthesia, and Department of Surgery, St. Vincent\u2019s Hospital, The University of\r Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"},{"name":"The University of Melbourne Academic Unit for Psychiatry of\r Old Age, St George\u2019s Hospital, Kew, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"},{"name":"Department of Nuclear Medicine and Centre for PET, Austin\r Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lance","family":"Macaulay","sequence":"additional","affiliation":[{"name":"CSIRO Food and Nutrition Flagship, Parkville, VIC,\r Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Darby","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research &\r Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia,\r Australia"},{"name":"Sir James McCusker Alzheimer\u2019s Disease Research Unit\r (Hollywood Private Hospital), Perth, WA, Australia"},{"name":"School of Psychiatry and Clinical Neurosciences, University\r of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ames","sequence":"additional","affiliation":[{"name":"The University of Melbourne Academic Unit for Psychiatry of\r Old Age, St George\u2019s Hospital, Kew, VIC, Australia"},{"name":"National Ageing Research Institute, Parkville, VIC,\r Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Collins","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The\r University of Melbourne, VIC, Australia"},{"name":"Department of Pathology, The University of Melbourne,\r Parkville, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and for the AIBL Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"AmesDBurnsAO\u2019BrienJ2010Dementia 4th edLondonHodder Arnold"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.226"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb02571.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.179"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131085"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.155"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007901"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1151-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70044-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.2008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.105"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23908"},{"key":"e_1_3_3_19_2","unstructured":"VillemagneVLFodero-TavolettiMTYatesPMastersCLRoweCC2014A\u03b2 imaging in aging Alzheimer\u2019s disease and other neurodegenerative conditionsDierckxRAOtteAde VriesEvan WaardeAPET and SPECT in Neurology213254Berlin-HeidelbergSpringer-Verlag"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2243"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.010"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02753.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.10.006"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.12.023"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70355-6"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.10.1776"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.007"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000228230.26044.a4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000261919.22630.ea"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209009405"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.870136"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22068"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70142-4"},{"key":"e_1_3_3_34_2","first-page":"302","article-title":"Automated quantification of [18F]flutemetamol data - Comparison with\n standard of truth based on histopathology","volume":"54","author":"Thurfjell L","year":"2013","unstructured":"ThurfjellLLundqvistRBuckleyCSmithASherwinP2013Automated quantification of [18F]flutemetamol data - Comparison with standard of truth based on histopathologyJ Nulc Med Meeting Abstr54302","journal-title":"J Nulc Med Meeting Abstr"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22248"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.07.004"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.9734\/AIR\/2014\/11599"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1358"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.02.016"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70194-7"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.02.004"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.04.011"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt34"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-150247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-150247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-150247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:44Z","timestamp":1777370564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-150247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,28]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,8,28]]}},"alternative-id":["10.3233\/JAD-150247"],"URL":"https:\/\/doi.org\/10.3233\/jad-150247","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,28]]}}}