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This devastating chronic condition generates a huge social and economic\n          burden and accounts for 11.2% of years of disability. The increase in lifespan has\n          contributed to the increase in dementia prevalence; however, there is currently no\n          curative treatment for most causes of dementias. This paper reviews evidence-based\n          strategies to build, enhance, and preserve cognition over the lifespan by examining\n          approaches that work best, proposing when in the life course they should be implemented,\n          and in which population group(s). Recent work shows a tendency to decreased age-specific\n          prevalence and incidence of cognitive problems and dementia among people born later in the\n          first half of the 20th century, citing higher educational levels, improvements in\n          lifestyle, and better handling of vascular risk factors. This implies that we can target\n          modifiable environmental, lifestyle, and health risk factors to modify the trajectory of\n          cognitive decline before the onset of irreversible dementia. Because building cognitive\n          reserve and prevention of cognitive decline are of critical importance, interventions are\n          needed at every stage of the life course to foster cognitive stimulation, and enable\n          healthy eating habits and physical activity throughout the lifespan. Preventive\n          interventions to decrease and delay cognitive decline and its consequences in old age will\n          also require collaboration and action on the part of policy-makers at the political and\n          social level.<\/jats:p>","DOI":"10.3233\/jad-150256","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T17:45:35Z","timestamp":1441215935000},"page":"35-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Prevention of Age-Related Cognitive Decline: Which Strategies, When,          and\u00a0forWhom?"],"prefix":"10.1177","volume":"48","author":[{"given":"Bryna","family":"Shatenstein","sequence":"first","affiliation":[{"name":"D\u00e9partement de nutrition, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al,\r          Qu\u00e9bec, Canada"},{"name":"Centre de recherche, Institut universitaire de g\u00e9riatrie de\r          Montr\u00e9al, CIUSSS Centre-est-de-l\u2019\u00cele-de-Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Barberger-Gateau","sequence":"additional","affiliation":[{"name":"University of Bordeaux, ISPED, Centre INSERM\r          U897-Epidemiologie-Biostatistique, Bordeaux, France"},{"name":"INSERM, ISPED, Centre INSERM\r          U897-Epidemiologie-Biostatistique, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"issue":"2","key":"e_1_3_1_2_2","first-page":"127","article-title":"Brain aging: Lessons from community studies.S119-S","volume":"68","author":"Fratiglioni L","year":"2010","unstructured":"FratiglioniLMangialascheFQiuC2010Brain aging: Lessons from community studies.S119-SNutr Rev68Suppl 2127","journal-title":"Nutr Rev"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.175"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","unstructured":"Barberger GateauPFeartCSamieriCLetenneurL2013Dietary patterns and dementiaYaffeKChronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain197224New York NYOxford University Press","DOI":"10.1093\/med\/9780199793556.003.0010"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2091"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093459"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.2"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000341271.90478.8e"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1204629"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834cd45b"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12058"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04056.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70136-X"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","unstructured":"Barberger GateauPSamieriCFeartCCunnaneS2014Nutrition and cognitive decline in older persons: Bridging the gap between epidemiology and intervention studiesFolkertsGGarssenJPharma-Nutrition. 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