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In the present review article, we examined clinical and\n          epidemiological studies investigating the possible role of different frailty models in\n          modulating the risk of Alzheimer\u2019s disease (AD), dementia, vascular dementia (VaD), mild\n          cognitive impairment (MCI), and late-life cognitive impairment\/decline that have been\n          published over the past 3 years. Both deficit accumulation and physical frailty models\n          were associated with late-life cognitive impairment\/decline, incident dementia, AD, MCI,\n          VaD, non-AD dementias, and AD pathology, proposing cognitive frailty as a new clinical\n          construct with coexisting physical frailty and cognitive impairment in nondemented older\n          subjects. Two subtypes of this new clinical condition have been recently proposed:\n          \u201cpotentially reversible\u201d cognitive frailty and \u201creversible\u201d cognitive frailty. The\n          physical factors should be physical prefrailty and frailty, while the cognitive impairment\n          of potentially reversible cognitive frailty should be MCI (Clinical Dementia rating\n          Scale\u200a=\u200a0.5), while the cognitive impairment of reversible cognitive frailty should be\n          pre-MCI Subjective Cognitive Decline (SCD), as recently proposed by the SCD Initiative\n          Working Group. The mechanisms underlying the cognitive-frailty link are multifactorial and\n          vascular, inflammatory, nutritional, and metabolic influences may be of major relevance.\n          Considering both physical frailty and cognition as a single complex phenotype may be\n          crucial in the prevention of dementia and its subtypes with secondary preventive trials on\n          cognitive frail older subjects.<\/jats:p>","DOI":"10.3233\/jad-150358","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T09:29:50Z","timestamp":1439458190000},"page":"793-813","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":116,"title":["Targeting Cognitive Frailty: Clinical and Neurobiological Roadmap for a          Single Complex Phenotype"],"prefix":"10.1177","volume":"47","author":[{"given":"Francesco","family":"Panza","sequence":"first","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Basic Medicine,\r          Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy"},{"name":"Department of Clinical Research in Neurology, University of\r          Bari Aldo Moro, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"},{"name":"Geriatric Unit &amp; Laboratory of Gerontology and\r          Geriatrics, Department of Medical Sciences, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, San\r          Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Seripa","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and\r          Geriatrics, Department of Medical Sciences, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, San\r          Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Solfrizzi","sequence":"additional","affiliation":[{"name":"Geriatric Medicine-Memory Unit and Rare Disease Centre,\r          University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Tortelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, University of\r          Bari Aldo Moro, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Greco","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and\r          Geriatrics, Department of Medical Sciences, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, San\r          Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Department of OrthoGeriatrics,\r          Rehabilitation and Stabilization, Frailty Area, Galliera Hospital NR-HS, Genova,\r          Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Basic Medicine,\r          Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy"},{"name":"Department of Clinical Research in Neurology, University of\r          Bari Aldo Moro, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"e47","article-title":"Alzheimer\u2019s Association report","volume":"10","author":"Fargo K","year":"2014","unstructured":"FargoKBleilerL2014Alzheimer\u2019s Association reportAlzheimers Dement10e47e92","journal-title":"Alzheimers 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