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Our results demonstrate that although A\u03b2PP is overexpressed in some of the mitral cells, widespread A\u03b2 deposition and microglia aggregates are not prevalent in the olfactory bulb. The olfactory bulbs of the younger J20 group harbored significantly fewer neurons than those of the age-matched wild-type mice (5.57\u00b10.13 million versus 6.59\u00b10.36 million neurons; p\u200a=\u200a0.011). In contrast, the number of proliferating cells was higher in the young J20 than in the wild-type group (i.e., 6617\u00b1425 versus 4455\u00b1623 cells; p\u200a=\u200a0.011). A significant increase in neurogenic activity was also observed in the younger J20 olfactory bulb. In conclusion, our results indicate that (1) neurons participating in the mouse olfactory function overexpress A\u03b2PP; (2) the cellular composition of the young J20 olfactory bulb is different from that of wild-type littermates; (3) these differences may reflect altered neurogenic activity and\/or delayed development of the J20 olfactory system; and (4) A\u03b2PP\/A\u03b2-associated pathological changes that take place in the J20 hippocampus and olfactory bulb are not identical.<\/jats:p>","DOI":"10.3233\/jad-150368","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T08:37:04Z","timestamp":1448613424000},"page":"443-457","source":"Crossref","is-referenced-by-count":5,"title":["Early in vivo Effects of the Human Mutant Amyloid-\u03b2 Protein Precursor (hA\u03b2PPSwInd) on the Mouse Olfactory Bulb"],"prefix":"10.1177","volume":"49","author":[{"given":"Zolt\u00e1n","family":"Ruszn\u00e1k","sequence":"first","affiliation":[{"name":"Neuroscience 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