{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:25:33Z","timestamp":1778678733533,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2015,11,3]]},"abstract":"<jats:p>Background: Patients with celiac disease (CD) frequently report cognitive symptoms when they are exposed to gluten, and cognitive deficits have been quantified in patients with newly diagnosed CD. Objective: To determine whether patients with CD have an increased risk of dementia. Methods: Using a population-based database of older adults (age \u226550 years) with histologically proven CD (duodenal\/jejunal villous atrophy) from all 28 pathology departments in Sweden, we compared the incidence of a subsequent dementia diagnosis to those of age- and gender-matched controls. Results: Among patients with CD (n\u200a=\u200a8,846) and controls (n\u200a=\u200a43,474), the median age was 63 years and 56% were female. During a median follow-up time of 8.4 years, dementia was diagnosed in 4.3% of CD patients and 4.4% of controls (HR 1.07; 95% CI 0.95\u20131.20). Although there was an increased risk of dementia in the first year following a diagnosis of CD (HR 1.73; 95% CI 1.15\u20132.61), this risk was not present in the whole observation period. Among those subjects with a dementia subtype specified, the increased risk was restricted to vascular dementia (HR 1.28; 95% CI 1.00\u20131.64) and was not present for Alzheimer\u2019s dementia (HR 1.12; 95% CI 0.91\u20131.37). Conclusions: Patients with CD are not at increased risk for dementia overall, though subgroup analysis suggests that they may be at increased risk for vascular dementia.<\/jats:p>","DOI":"10.3233\/jad-150388","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T11:24:33Z","timestamp":1446549873000},"page":"179-185","source":"Crossref","is-referenced-by-count":37,"title":["Risk of Dementia in Patients with Celiac Disease: A Population-Based Cohort Study"],"prefix":"10.1177","volume":"49","author":[{"given":"Benjamin","family":"Lebwohl","sequence":"first","affiliation":[{"name":"Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA"},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Luchsinger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Freedberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.R.","family":"Green","sequence":"additional","affiliation":[{"name":"Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, 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