{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:27:45Z","timestamp":1777393665969,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2015,11,3]]},"abstract":"<jats:p>Age is the major risk factor for developing Alzheimer\u2019s disease (AD), and modifying age-related factors may help to delay the onset of the disease. The goal of this study was to investigate the relationship between age and the metabolic factors related to the risk of developing AD. The concentrations of insulin, amylin, and amyloid-\u03b2 peptide (A\u03b2) in plasma were measured. We further measured the activity of serum A\u03b2 degradation by using fluorescein- and biotin-labeled A\u03b240. Apolipoprotein E4 allele (ApoE4) and cognitive impairment were characterized. Subjects were divided into three age groups: 60\u201370, 70\u201380, and \u226580 years old. We found that the older the subjects, the lower the concentration of insulin (p\u200a=\u200a0.001) and the higher the concentration of A\u03b21-40 (p\u200a=\u200a0.004) in plasma. However, age was not associated with the concentration of another pancreatic peptide, amylin, and only marginally with A\u03b21-42. These relationships remained in the absence of diabetes, cardiovascular disease, and stroke, and regardless of the presence of ApoE4 and cognitive impairment. Both age and ApoE4 were inversely associated with, while insulin was positively associated with, the activities of A\u03b2 degradation in serum. Our study suggested that low concentration of insulin and high concentration of A\u03b240 are aging factors related to the risk of AD.<\/jats:p>","DOI":"10.3233\/jad-150428","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T11:24:38Z","timestamp":1446549878000},"page":"129-137","source":"Crossref","is-referenced-by-count":14,"title":["Age and Its Association with Low Insulin and High Amyloid-\u03b2 Peptides in Blood"],"prefix":"10.1177","volume":"49","author":[{"given":"Huajie","family":"Li","sequence":"first","affiliation":[{"name":"Departments of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Neurology, The First People\u2019s Hospital of Chang Zhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Wallack","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mkaya","family":"Mwamburi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Family Medicine, Tufts University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer O.","family":"Abdul-Hay","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm A.","family":"Leissring","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei 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