{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:46:55Z","timestamp":1790650015860,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,1,22]]},"abstract":"<jats:p>Background: The existing pharmacological treatments for Alzheimer\u2019s disease (AD) can only slow the progression of symptoms or delay admission to long-term care facilities. The beneficial effects of non-drug treatments are poorly studied. Objective: To describe the effects of an Integrated Psychostimulation Program (IPP) in patients with mild-moderate AD treated with acetylcholinesterase inhibitors; and to identify factors related to greater benefit of the IPP. Methods: 206 patients (mean age\u200a=\u200a75.9 years; MMSE\u200a=\u200a19.6) were evaluated before starting the IPP and 3, 6, 9, and 12 months later. Measures included: Mini-Mental State Examination (MMSE), Cognitive Subscale of Alzheimer\u2019s Disease Assessment Scale (ADAS-Cog), Rapid Disability Rating Scale (RDRS-2), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results: Patients remained cognitively stable (MMSE\/ADAS-Cog) for more than 6 months and significantly worsened at 9-month and 12-month follow-ups, without clinically significant functional changes (RDRS-2) or psychiatric symptoms(NPI-Q). The mean annual change on MMSE and ADAS-Cog were 2.06 and 3.56 points, respectively, lower than the annual decline demonstrated previously in similar patients (2.4 and 4.5, respectively). 42.7% of patients maintained or improved global cognitive scores between baseline and 12-month follow-up. The patients who maintained cognitive functions were older than those who did not (77.5 versus 74.7 years). Conclusions: The IPP may be an effective treatment to maintain cognition, functionality, and psychiatric symptoms in AD patients pharmacologically treated, and older age seems to increase beneficial effects of IPP.<\/jats:p>","DOI":"10.3233\/jad-150455","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T09:24:16Z","timestamp":1453454656000},"page":"559-566","source":"Crossref","is-referenced-by-count":10,"title":["Beneficial Effects of an Integrated Psychostimulation Program in Patients with Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"50","author":[{"given":"Marta","family":"Ibarria","sequence":"first","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"},{"name":"Memory Clinic of Fundaci\u00f3 ACE, Institut Catal\u00e1 de Neuroci\u00e8ncies Aplicades, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Fundaci\u00f3 ACE Alzheimer Research Center and Memory Clinic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alegret","sequence":"additional","affiliation":[{"name":"Memory Clinic of Fundaci\u00f3 ACE, Institut Catal\u00e1 de Neuroci\u00e8ncies Aplicades, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Valero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hospital Universitari Vall d\u2019Hebron. 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Moreno","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"},{"name":"Memory Clinic of Fundaci\u00f3 ACE, Institut Catal\u00e1 de Neuroci\u00e8ncies Aplicades, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Lara","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Diego","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"},{"name":"Memory Clinic of Fundaci\u00f3 ACE, Institut Catal\u00e1 de Neuroci\u00e8ncies Aplicades, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e0lia","family":"Tantiny\u00e1","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Vera","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Alzheimer Center Educational, Day Care Centers of Fundaci\u00f3 ACE, Barcelona, Spain"},{"name":"Memory Clinic of Fundaci\u00f3 ACE, Institut Catal\u00e1 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