{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:09:05Z","timestamp":1783584545796,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2015,11,27]]},"abstract":"<jats:p>Background: Young onset dementia (YOD) presents in individuals who are economically productive and socially active. While the cost related to dementia in the elderly has been widely studied, the cost related to YOD is largely unknown. Objective: To study the economic burden of community dwelling YOD in relation to late onset dementia (LOD) and cost of YOD based on etiology. Methods: In this prospective cross-sectional study of 255 patients attending a tertiary neurology center, data on economic burden, clinical features, and caregiver burden were collected using structured financial questionnaire, standard cognitive and neuropsychiatric measures, and Zarit caregiver burden scale. Cost components were grouped into those relating to direct medical costs, direct non-medical costs, and those related to indirect costs. Cost was also categorized based on etiology of YOD. Results: The mean age at symptom onset in the YOD and LOD cohort was 57.0 (SD 5.1) and 75.0 (SD 5.9) years, respectively. The median annual cost for patients with YOD was almost twice that of LOD (USD 15,815 versus USD 8,396). Indirect cost contributed heavily to cost related to YOD. Even when grouped by dementia etiology, YOD patients with Alzheimer\u2019s disease, frontotemporal dementia (FTD), and vascular dementia had higher cost compared to their elderly counterparts. Young onset FTD had the highest cost. 43.2% of YOD reported loss of employment due to dementia, which was significantly higher than that in LOD (2.4%). Conclusion: Patients with YOD have a high economic burden. Young patients with FTD have the highest cost followed by vascular dementia and Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3233\/jad-150471","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T08:36:11Z","timestamp":1448613371000},"page":"277-285","source":"Crossref","is-referenced-by-count":36,"title":["Cost Related to Dementia in the Young and the Impact of Etiological Subtype on Cost"],"prefix":"10.1177","volume":"49","author":[{"given":"Nagaendran","family":"Kandiah","sequence":"first","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"},{"name":"Duke-NUS, Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Mei","family":"Nyu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahul","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwee Lin","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150471_ref1","unstructured":"World Health Organization 2012 Dementia: A public health priority Geneva World Health Organization"},{"key":"10.3233\/JAD-150471_ref2","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: A Delphi consensus study","volume":"366","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"10.3233\/JAD-150471_ref3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0895-4356(00)00371-1","article-title":"Institutionalisation in the elderly: The role of chronic diseases and dementia. 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