{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:31:16Z","timestamp":1777393876490,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,1,12]]},"abstract":"<jats:p>We sought to determine whether there is any association between a cardiac workload marker, rate pressure product (RPP), working memory, and cortical amyloid-\u03b2 (A\u03b2) burden in 63 cognitively normal midlife adults (Mage\u200a=\u200a62.8 years; range\u200a=\u200a55 to 75 years) at risk for Alzheimer\u2019s disease (AD). The results show a small-to-moderate relationship between increasing cardiac workload (at rest) and neocortical amyloidosis in individuals at the preclinical stage of AD. Moreover, increasing RPP was linearly related to increasing relative impairments on a spatial working memory task (R2\u200a=\u200a0.30), but only for those individuals with neuroimaging evidence suggestive of preclinical AD. These results support a relationship between the aggregation of A\u03b2 protein plaques in the neocortex, increased cognitive impairment, and more inefficient myocardial oxygen use in the absence of significant metabolic demands.<\/jats:p>","DOI":"10.3233\/jad-150576","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T10:10:45Z","timestamp":1452247845000},"page":"127-131","source":"Crossref","is-referenced-by-count":6,"title":["Resting-State Cardiac Workload is Related to Both Increased Neocortical Aggregation of Amyloid-\u03b2 and Relative Impairments in Spatial Working Memory in Pre-Clinical Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"50","author":[{"given":"Cl\u00e1udia Yang","family":"Santos","sequence":"first","affiliation":[{"name":"Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Ying","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA"},{"name":"The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chih","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Timothy","family":"Machan","sequence":"additional","affiliation":[{"name":"Lifespan Biostatistics Core, Lifespan Hospital System, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahena","family":"Polynice","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Schindler","sequence":"additional","affiliation":[{"name":"Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Cogstate Ltd., Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Jeffrey","family":"Snyder","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA"},{"name":"Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150576_ref1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atheriosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer\u2019s disease in the Rotterdam study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"key":"10.3233\/JAD-150576_ref2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain infarction and clinical expression of Alzheimer\u2019s disease. 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