{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:38:19Z","timestamp":1777394299382,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,6,22]]},"DOI":"10.3233\/jad-150642","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T03:09:23Z","timestamp":1466651363000},"page":"127-133","source":"Crossref","is-referenced-by-count":39,"title":["Intracerebroventricular Infusion of Angiotensin-(1\u20137) Ameliorates Cognitive Impairment and Memory Dysfunction in a Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"53","author":[{"given":"Ken","family":"Uekawa","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Senju","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Nakagata","sequence":"additional","affiliation":[{"name":"Division of Reproductive Engineering, Center for Animal Resources and Development, Kumamoto University, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjie","family":"Ma","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Koibuchi","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shokei","family":"Kim-Mitsuyama","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150642_ref1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1474-4422(07)70077-7","article-title":"Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer\u2019s disease?","volume":"6","author":"Kehoe","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150642_ref2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.expneurol.2009.09.012","article-title":"The brain RAS and Alzheimer\u2019s disease","volume":"223","author":"Wright","year":"2010","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-150642_ref3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fendo.2013.00158","article-title":"A role for the brain RAS in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"4","author":"Wright","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.3233\/JAD-150642_ref4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","article-title":"Associations of anti-hypertensive treatments with Alzheimer\u2019s disease, vascular dementia, and other dementias","volume":"26","author":"Davies","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-150642_ref5","doi-asserted-by":"crossref","first-page":"b5465","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis","volume":"340","author":"Li","year":"2010","journal-title":"BMJ"},{"key":"10.3233\/JAD-150642_ref6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/01.WNL.0000140705.23869.E9","article-title":"Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression","volume":"63","author":"Ohrui","year":"2004","journal-title":"Neurology"},{"key":"10.3233\/JAD-150642_ref7","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: Results from the Cardiovascular Health Study","volume":"169","author":"Sink","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.3233\/JAD-150642_ref8","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archinte.163.9.1069","article-title":"Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease","volume":"163","author":"Tzourio","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.3233\/JAD-150642_ref9","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1113\/expphysiol.2011.058578","article-title":"Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke","volume":"96","author":"Mecca","year":"2011","journal-title":"Exp Physiol"},{"key":"10.3233\/JAD-150642_ref10","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-12-0341","article-title":"Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: New players of the renin-angiotensin system","volume":"216","author":"Santos","year":"2013","journal-title":"J Endocrinol"},{"key":"10.3233\/JAD-150642_ref11","doi-asserted-by":"crossref","first-page":"R804","DOI":"10.1152\/ajpregu.00222.2010","article-title":"ACE2\/ANG-(1-7)\/Mas pathway in the brain: The axis of good","volume":"300","author":"Xu","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.3233\/JAD-150642_ref12","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-150642_ref13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0361-9230(94)90104-X","article-title":"Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): Evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors","volume":"35","author":"Santos","year":"1994","journal-title":"Brain Res Bull"},{"key":"10.3233\/JAD-150642_ref14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2008.04.057","article-title":"Effects of intracerebroventricular infusion of angiotensin-(1-7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia-reperfusion in rats","volume":"1219","author":"Lu","year":"2008","journal-title":"Brain Res"},{"key":"10.3233\/JAD-150642_ref15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.npep.2008.09.005","article-title":"Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia\/reperfusion in rats","volume":"42","author":"Zhang","year":"2008","journal-title":"Neuropeptides"},{"key":"10.3233\/JAD-150642_ref16","first-page":"e50326","article-title":"Direct intraventricular delivery of drugs to the rodent central nervous system","author":"DeVos","year":"2013","journal-title":"J Vis Exp"},{"key":"10.3233\/JAD-150642_ref17","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/ATVBAHA.113.302440","article-title":"Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion","volume":"34","author":"Toyama","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3233\/JAD-150642_ref18","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1161\/STROKEAHA.112.653204","article-title":"Cerebral hemodynamic reserve and vascular remodeling in C57\/BL6 mice are influenced by age","volume":"43","author":"Hecht","year":"2012","journal-title":"Stroke"},{"key":"10.3233\/JAD-150642_ref19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.109.138586","article-title":"Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling","volume":"54","author":"Takeda","year":"2009","journal-title":"Hypertension"},{"key":"10.3233\/JAD-150642_ref20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00441-012-1354-3","article-title":"Immunohistochemical localization of the angiotensin-(1-7) receptor Mas in the murine forebrain","volume":"348","author":"Freund","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.3233\/JAD-150642_ref21","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/j.1476-5381.2012.02105.x","article-title":"Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia","volume":"167","author":"Jiang","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.3233\/JAD-150642_ref22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuropharm.2013.03.025","article-title":"Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke","volume":"71","author":"Regenhardt","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.3233\/JAD-150642_ref23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnagi.2014.00032","article-title":"Imaging of cerebrovascular pathology in animal models of Alzheimer\u2019s disease","volume":"6","author":"Klohs","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-150642_ref24","doi-asserted-by":"crossref","first-page":"e16037","DOI":"10.1371\/journal.pone.0016037","article-title":"Central angiotensin II stimulation promotes beta amyloid production in Sprague Dawley rats","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"10.3233\/JAD-150642_ref25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1474-4422(04)00683-0","article-title":"Is Alzheimer\u2019s disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics","volume":"3","author":"de la Torre","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150642_ref26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer\u2019s disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-150642_ref27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3988\/jcn.2007.3.1.18","article-title":"Decreased vasomotor reactivity in Alzheimer\u2019s disease","volume":"3","author":"Lee","year":"2007","journal-title":"J Clin Neurol"},{"key":"10.3233\/JAD-150642_ref28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","article-title":"Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam Study","volume":"57","author":"Ruitenberg","year":"2005","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150642_ref29","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/01.STR.0000206439.62025.97","article-title":"Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease","volume":"37","author":"Silvestrini","year":"2006","journal-title":"Stroke"},{"key":"10.3233\/JAD-150642_ref30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JAD-150274","article-title":"Cerebral amyloid angiopathy-related microbleeds correlate with glucose metabolism and brain volume in Alzheimer\u2019s disease","volume":"48","author":"Samuraki","year":"2015","journal-title":"J Alzheimers Dis"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-150642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:54Z","timestamp":1777370574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-150642"}},"subtitle":[],"editor":[{"given":"Masahito","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":30,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-150642","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}