{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:29:45Z","timestamp":1777393785004,"version":"3.51.4"},"reference-count":84,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer\u2019s disease (AD) and other dementias. A better understanding of the genetic factors regulating homocysteine levels, particularly in non-white populations, may help in risk stratification analyses of existing clinical trials and may point to novel targets for homocysteine-lowering therapy. To identify genetic influences on plasma homocysteine levels in individuals with African ancestry, we performed a targeted gene and pathway-based analysis using\n                    <jats:italic>a priori<\/jats:italic>\n                    biological information and then to identify new association performed a genome-wide association study. All analyses used combined data from the African American and Yoruba cohorts from the Indianapolis-Ibadan Dementia Project. Targeted analyses demonstrated significant associations of homocysteine and variants within the\n                    <jats:italic>CBS<\/jats:italic>\n                    (Cystathionine beta-Synthase) gene. We identified a novel genome-wide significant association of the AD risk gene\n                    <jats:italic>CD2AP<\/jats:italic>\n                    (CD2-associated protein) with plasma homocysteine levels in both cohorts. Minor allele (T) carriers of identified\n                    <jats:italic>CD2AP<\/jats:italic>\n                    variant (rs6940729) exhibited decreased homocysteine level. Pathway enrichment analysis identified several interesting pathways including the GABA receptor activation pathway. This is noteworthy given the known antagonistic effect of homocysteine on GABA receptors. These findings identify several new targets warranting further investigation in relation to the role of homocysteine in neurodegeneration.\n                  <\/jats:p>","DOI":"10.3233\/jad-150651","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T09:23:48Z","timestamp":1451381028000},"page":"991-1003","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians"],"prefix":"10.1177","volume":"49","author":[{"given":"Sungeun","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Center for Computational Biology and Bioinformatics, Indiana 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