{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:27:53Z","timestamp":1791224873984,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,1,22]]},"abstract":"<jats:p>Background: Progranulin is implicated in frontotemporal dementia (FTD), but its role in other neurodegenerative disorders is unknown. Objective: To investigate the levels of progranulin (PGRN) in cerebrospinal fluid (CSF) in different neurodegenerative dementias and their correlation with levels in plasma in cognitively normal subjects. Methods: We measured PGRN in CSF in 229 patients with amnestic mild cognitive impairment, Alzheimer\u2019s disease dementia, sporadic FTD, dementia with Lewy bodies, corticobasal syndrome, or progressive supranuclear palsy. We also measured PGRN in CSF and plasma in 74 cognitively normal individuals. We examined the correlation between PGRN levels in CSF and diagnosis, cortical thickness, genetic factors and other CSF biomarkers. We also investigated the correlation between plasma and CSF levels of PGRN in cognitively normal individuals. Results: CSF levels did not differ across diagnoses or correlate with cortical thickness. Polymorphism rs5848 in GRN influenced CSF PGRN levels, but APOE \u025b4 allele did not. Amyloid-\u03b242, t-tau, p-tau, and YKL-40 levels correlated weakly with PGRN in CSF. We found a weak correlation (r\u200a=\u200a0.362) between plasma and CSF PGRN levels in cognitively normal individuals. Conclusions: Our findings do not support a diagnostic value of CSF PGRN in neurodegenerative diseases. Our data confirm that levels of PGRN in plasma do not reflect accurately levels in CSF in cognitively normal controls. These data should be considered in clinical trials aiming to increase PGRN.<\/jats:p>","DOI":"10.3233\/jad-150746","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T09:26:32Z","timestamp":1453454792000},"page":"539-546","source":"Crossref","is-referenced-by-count":47,"title":["Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias"],"prefix":"10.1177","volume":"50","author":[{"given":"Estrella","family":"Morenas-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cervera-Carles","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vilaplana","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de 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CIBERNED, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Ribosa-Nogu\u00e9","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Mu\u00f1oz-Llahuna","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Blesa","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Clarim\u00f3n","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d\u2019Investigacions Biom\u00e8diques Sant Pau - Hospital de Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en enfermedades Neurodegenerativas, CIBERNED, 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involvement","volume":"70","author":"Guerreiro","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-150746_ref38","doi-asserted-by":"crossref","unstructured":"Kleinberger G , Yamanishi Y , Suarez-Calvet M , Czirr E , Lohmann E , Cuyvers E , Struyfs H , Pettkus N , Wenninger-Weinzierl A , Mazaheri F , Tahirovic S , Lleo A , Alcolea D , Fortea J , Willem M , Lammich S , Molinuevo JL , Sanchez-Valle R , Antonell A , Ramirez A , Heneka MT , Sleegers K , van der Zee J , Martin JJ , Engelborghs S , Demirtas-Tatlidede A , Zetterberg H , Van Broeckhoven C , Gurvit H , Wyss-Coray T , Hardy J , Colonna M , Haass C (2014) TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med 6, 243ra286.","DOI":"10.1126\/scitranslmed.3009093"},{"key":"10.3233\/JAD-150746_ref39","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopsych.2010.08.025","article-title":"YKL-40: A novel prognostic fluid biomarker for preclinical Alzheimer\u2019s disease","volume":"68","author":"Craig-Schapiro","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.3233\/JAD-150746_ref40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/alzrt163","article-title":"Plasma tau levels in Alzheimer\u2019s disease","volume":"5","author":"Zetterberg","year":"2013","journal-title":"Alzheimers Res Ther"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-150746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:01:58Z","timestamp":1777370518000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-150746"}},"subtitle":[],"editor":[{"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,22]]},"references-count":40,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-150746","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,22]]}}}