{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:32:59Z","timestamp":1777393979700,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,2,22]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The pharmacological treatment of Alzheimer\u2019s disease (AD) is based largely on cholinesterase inhibitors (ChEI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether or not some non-pharmacological and contextual factors measured prior to starting treatment such as past occupation, lifestyles, marital status, degree of autonomy and cognitive impairment, living alone or with others, and the degree of brain atrophy are associated with a better response to ChEI treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eighty-four AD and six AD with cerebrovascular disease (AD +\u200aCVD) outpatients of Treviso Dementia (TREDEM) Registry, with an average cholinesterase inhibitors treatment length of four years, were considered. The outpatients had undergone a complete evaluation and some non-pharmacological and contextual factors were collected. We defined responder a patient with a delta score T0 \u2013 T1 equal or inferior to 2.0 points per year of MMSE and a non-responder a patient with a delta score T0 \u2013 T1 superior to 2.0 points per year. In order to identify hidden relationships between variables related to response and non-response, we use a special kind of artificial neural network called Auto-CM, able to create a semantic connectivity map of the variables considered in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A higher cognitive profile, a previous intellectual occupation, healthier lifestyles, being married and not living alone, a higher degree of autonomy, and lower degree of brain atrophy at baseline resulted in affecting the response to long-term ChEI therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Non-pharmacological and contextual factors appear to influence the effectiveness of treatment with ChEI in the long term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-150747","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T11:45:42Z","timestamp":1456227942000},"page":"969-979","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Predictors of Response to Cholinesterase Inhibitors Treatment of Alzheimer\u2019s Disease: Date Mining from the TREDEM Registry"],"prefix":"10.1177","volume":"50","author":[{"given":"Maurizio","family":"Gallucci","sequence":"first","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority 9 of Treviso, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority 9 of Treviso, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Aric\u00f2","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority 9 of Treviso, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Grossi","sequence":"additional","affiliation":[{"name":"Villa Santa Maria Institute, Tavernerio, Italy"},{"name":"Semeion Research Centre of Sciences of Communication, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.04.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000266627.96040.5a"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08267-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074140"},{"key":"e_1_3_2_6_2","first-page":"CD001191","article-title":"Rivastigmine for Alzheimer\u2019s disease","author":"Birks J","year":"2002","unstructured":"BirksJ, GrimleyEJ, IakovidouV (2002) Rivastigmine for Alzheimer\u2019s disease. 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