{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:32:00Z","timestamp":1777393920130,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,1,22]]},"abstract":"<jats:p>Background: A common polymorphism of the butyrylcholinesterase gene, the K-variant (BCHE-K) is associated with reduced butyrylcholinesterase (BuChE) activity. Insufficient studies exist regarding the frequency and role of BCHE-K in dementias. Objective: To determine the association of BCHE-K and APOE \u025b4 with diagnosis and rate of cognitive decline in dementia with Lewy bodies (DLB) and Alzheimer\u2019s disease (AD) patients. Methods: Genomic DNA from 368 subjects (108 AD, 174 DLB, and 86 controls) from two routine clinical cohort studies in Norway; DemVest and Tr\u00f8nderBrain, were genotyped for BCHE-K and APOE \u025b4. The mild dementia DemVest subjects received annual Mini-Mental State Examination assessments for five years. Results: BCHE-K frequency was lower in DLB (33.9% ; p\u200a&lt; \u200a0.01) than in control subjects (51.2%), and was numerically lower in AD as well (38.9% ; p\u200a=\u200a0.11). More rapid cognitive decline was associated with the APOE \u025b4 genotype, but not with the BCHE-K genotype. In an exploratory analysis of patients who completed all five follow-up visits, there was greater cognitive decline in BCHE-K carriers in the presence of the APOE \u025b4 allele than in the absence of these polymorphisms. Conclusion: BCHE-K is associated with a reduced risk for AD and DLB whereas APOE \u025b4 is associated with more rapid cognitive decline. The greater cognitive decline in individuals with both APOE \u025b4 and BCHE-K alleles require prospective confirmation in well-controlled trials.<\/jats:p>","DOI":"10.3233\/jad-150750","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T09:19:51Z","timestamp":1453454391000},"page":"567-576","source":"Crossref","is-referenced-by-count":15,"title":["Association of Butyrylcholinesterase-K Allele and Apolipoprotein E \u025b4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"50","author":[{"given":"Swetha","family":"Vijayaraghavan","sequence":"first","affiliation":[{"name":"Center for Alzheimer Research,Division of Translational Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden"},{"name":"Center for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taher","family":"Darreh-Shori","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research,Division of Translational Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvid","family":"Rongve","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, and Institute of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guro","family":"Berge","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid B.","family":"Sando","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"},{"name":"Department of Neurology, University Hospital of Trondheim, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda R.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"},{"name":"Department of Neurology, University Hospital of Trondheim, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn H.","family":"Auestad","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway"},{"name":"Research Department, Stavanger University hospital, Stavanger, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aree","family":"Witoelar","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway"},{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), University of Oslo\/Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway"},{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), University of Oslo\/Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingun D.","family":"Ulstein","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Norwegian Center for Aging and Health, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden"},{"name":"Center for Age Related Medicine, Stavanger University Hospital, Stavanger, 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