{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:38Z","timestamp":1792670858430,"version":"4.5.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Postmortem neuropathological examination of the brain is essential in neurodegenerative diseases, to ensure accurate diagnosis, to obtain an\n                    <jats:italic>a posteriori<\/jats:italic>\n                    critical assessment of the adequacy of clinical care, and to validate new biomarkers, but is only rarely performed. The purpose of this study was to assess factors limiting brain donation, such as reluctance of physicians to seek donation consent, opposition from patients and families, and organizational constraints. We conducted a survey across French memory clinics and major neuropathological centers. Few postmortem examinations were performed annually, as less than one third of the centers had performed at least five autopsies, and 41% had performed none. The main limiting factor was the lack of donation requests made by physicians, as half of them never approach patients for brain donation. Reasons for not seeking donation consent often include discomfort broaching the subject and lack of awareness of the medical and scientific benefit of postmortems (77%), organizational constraints (61%), and overestimation of families\u2019 negative reaction (51%). Family refusals represented a second major obstacle, and were often caused by misconceptions. Identifying and addressing these biases early could help improve physicians\u2019 rate of making requests and the public\u2019s awareness about the importance of brain donation.\n                  <\/jats:p>","DOI":"10.3233\/jad-150825","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T09:24:42Z","timestamp":1451381082000},"page":"1075-1083","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Limiting Factors of Brain Donation in Neurodegenerative Diseases: The Example of French Memory Clinics"],"prefix":"10.1177","volume":"49","author":[{"given":"Raphael","family":"Le Bouc","sequence":"first","affiliation":[{"name":"Memory Clinic, French National Reference Centre for Young Onset Alzheimer\u2019s disease, Lille University Hospital, INSERM U1171, LabEx DISTALZ, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Marelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHRU Gui de Chauliac, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Beaufils","sequence":"additional","affiliation":[{"name":"Regional Memory Center, CHU H\u00f4pital Bretonneau, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Berr","sequence":"additional","affiliation":[{"name":"INSERM E361, Pathologies of the Nervous System, Clinical and Epidemiological Research, H\u00f4pital La Colombi\u00e9re, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hommet","sequence":"additional","affiliation":[{"name":"Regional Memory Center, CHU H\u00f4pital Bretonneau, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Touchon","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHRU Gui de Chauliac, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pasquier","sequence":"additional","affiliation":[{"name":"Memory Clinic, French National Reference Centre for Young Onset Alzheimer\u2019s disease, Lille University Hospital, INSERM U1171, LabEx DISTALZ, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[{"name":"Memory Clinic, French National Reference Centre for Young Onset Alzheimer\u2019s disease, Lille University Hospital, INSERM U1171, LabEx DISTALZ, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.080754"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.12.1696"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.2008"},{"key":"e_1_3_2_5_2","first-page":"177","article-title":"About a peculiar disease of the cerebral cortex","volume":"30","author":"Alzheimer A","year":"1907","unstructured":"AlzheimerA (1907) About a peculiar disease of the cerebral cortex. 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