{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:31:53Z","timestamp":1790145113414,"version":"4.0.1"},"reference-count":79,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,2,2]]},"DOI":"10.3233\/jad-150897","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T08:37:17Z","timestamp":1454920637000},"page":"873-886","source":"Crossref","is-referenced-by-count":106,"title":["Cerebrospinal Fluid Markers of Alzheimer\u2019s Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"50","author":[{"given":"Kelsey E.","family":"Melah","sequence":"first","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Yuan-Fu","family":"Lu","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan M.","family":"Hoscheidt","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Adluru","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Destiche","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"UCL Institute of Neurology, Queen Square, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma C.","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Wisconsin Alzheimer\u2019s Institute, School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey E.","family":"Gleason","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Maritza","family":"Dowling","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Bratzke","sequence":"additional","affiliation":[{"name":"School of Nursing, Wisconsin School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Rowley","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Sager","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Institute, School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Asthana","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Wisconsin Alzheimer\u2019s Institute, School of Medicine and Public Health, Madison, WI, USA"},{"name":"Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Bendlin","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Wisconsin Alzheimer\u2019s Institute, School of Medicine and Public Health, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150897_ref1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0278-5846(03)00124-6","article-title":"Inflammatory processes in Alzheimer\u2019s disease","volume":"27","author":"McGeer","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.3233\/JAD-150897_ref3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.10414","article-title":"Plasma and cerebrospinal fluid \u03b11-antichymotrypsin levels in Alzheimer\u2019s disease: Correlation with cognitive impairment","volume":"53","author":"DeKosky","year":"2003","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150897_ref4","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.neurobiolaging.2005.10.007","article-title":"Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer\u2019s disease","volume":"27","author":"Galimberti","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref5","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/jnnp.74.9.1200","article-title":"Intrathecal inflammation precedes development of Alzheimer\u2019s disease","volume":"74","author":"Tarkowski","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-150897_ref6","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/brain\/awt171","article-title":"Dissecting phenotypic traits linked to human resilience to Alzheimer\u2019s pathology","volume":"136","author":"Perez-Nievas","year":"2013","journal-title":"Brain"},{"key":"10.3233\/JAD-150897_ref7","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archgenpsychiatry.2009.146","article-title":"Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease","volume":"66","author":"van Exel","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.3233\/JAD-150897_ref8","first-page":"1005","article-title":"Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?","volume":"12","author":"Wyss-Coray","year":"2006","journal-title":"Nat Med"},{"key":"10.3233\/JAD-150897_ref9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"10.3233\/JAD-150897_ref10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1196\/annals.1332.006","article-title":"Microglia as a potential bridge between the amyloid beta-peptide and tau","volume":"1035","author":"Kitazawa","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.3233\/JAD-150897_ref11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0046-8177(95)90001-2","article-title":"Glial cytokines in Alzheimer\u2019s disease: Review and pathogenic implications","volume":"26","author":"Mrak","year":"1995","journal-title":"Hum Pathol"},{"key":"10.3233\/JAD-150897_ref12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","article-title":"Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism","volume":"76","author":"Block","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-150897_ref13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-8993(96)00156-4","article-title":"\u03b2-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity","volume":"720","author":"Ii","year":"1996","journal-title":"Brain Res"},{"key":"10.3233\/JAD-150897_ref14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1523\/JNEUROSCI.21-04-01179.2001","article-title":"beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis","volume":"21","author":"Combs","year":"2001","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-150897_ref15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3233\/JAD-140624","article-title":"Cerebrospinal fluid level of YKL-40 protein in preclinical and prodromal Alzheimer\u2019s disease","volume":"42","author":"Antonell","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-150897_ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-2012-120787","article-title":"Microglial markers are elevated in the prodromal phase of Alzheimer\u2019s disease and vascular dementia","volume":"33","author":"Olsson","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-150897_ref17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopsych.2010.08.025","article-title":"YKL-40: A novel prognostic fluid biomarker for preclinical Alzheimer\u2019s disease","volume":"68","author":"Craig-Schapiro","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.3233\/JAD-150897_ref18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000362164","article-title":"Increased levels of chitotriosidase and YKL-40 in cerebrospinal fluid from patients with Alzheimer\u2019s disease","volume":"4","author":"Ros\u00e9n","year":"2014","journal-title":"Dement Geriatr Cogn Disord extra"},{"key":"10.3233\/JAD-150897_ref19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1750-3639.2010.00445.x","article-title":"Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism","volume":"21","author":"Yang","year":"2011","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-150897_ref20","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.neurobiolaging.2015.03.001","article-title":"Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer\u2019s disease","volume":"36","author":"Alcolea","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref21","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1046\/j.1471-4159.1996.67052013.x","article-title":"Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF","volume":"67","author":"Rosengren","year":"2002","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-150897_ref22","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1212\/WNL.50.4.1122","article-title":"CSF neurofilament and glial fibrillary acidic protein in normal pressure hydrocephalus","volume":"50","author":"Tullberg","year":"1998","journal-title":"Neurology"},{"key":"10.3233\/JAD-150897_ref23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1471-4159.1999.0720741.x","article-title":"Quantification of axonal damage in traumatic brain injury: Affinity purification and characterization of cerebrospinal fluid tau proteins","volume":"72","author":"Zemlan","year":"1999","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-150897_ref24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1258\/000456303321016141","article-title":"Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases","volume":"40","author":"Verbeek","year":"2003","journal-title":"Ann Clin Biochem"},{"key":"10.3233\/JAD-150897_ref25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.71.4.441","article-title":"Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer\u2019s disease","volume":"71","author":"Du","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-150897_ref26","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/WNL.52.7.1397","article-title":"Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment","volume":"52","author":"Jack","year":"1999","journal-title":"Neurology"},{"key":"10.3233\/JAD-150897_ref27","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jnnp.72.6.742","article-title":"White matter damage in Alzheimer\u2019s disease assessed in vivo using diffusion tensor magnetic resonance imaging","volume":"72","author":"Bozzali","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-150897_ref28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(02)00914-X","article-title":"Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging","volume":"332","author":"Takahashi","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150897_ref29","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1097\/01.wnr.0000174058.49521.16","article-title":"Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriers","volume":"16","author":"Nierenberg","year":"2005","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-150897_ref30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neurobiolaging.2005.03.026","article-title":"White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study","volume":"27","author":"Medina","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1148\/radiol.2432051714","article-title":"White matter damage in Alzheimer disease and mild cognitive impairment: Assessment with diffusion-tensor MR imaging and parallel imaging techniques","volume":"243","author":"Stahl","year":"2007","journal-title":"Radiology"},{"key":"10.3233\/JAD-150897_ref32","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.neuropsychologia.2007.12.010","article-title":"Functional relevant loss of long association fibre tracts integrity in early Alzheimer\u2019s disease","volume":"46","author":"Fellgiebel","year":"2008","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-150897_ref33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/jmri.21231","article-title":"Gray and white matter changes in Alzheimer\u2019s disease: A diffusion tensor imaging study","volume":"27","author":"Rose","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"10.3233\/JAD-150897_ref34","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3233\/JAD-2010-1295","article-title":"Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer\u2019s disease","volume":"19","author":"Canu","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-150897_ref35","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-2009-1163","article-title":"Impact of APOE on the healthy aging brain: A voxel-based MRI and DTI study","volume":"18","author":"Honea","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-150897_ref36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jalz.2009.11.003","article-title":"White matter is altered with parental family history of Alzheimer\u2019s disease","volume":"6","author":"Bendlin","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150897_ref37","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/archneurol.2011.208","article-title":"Role of family history for alzheimer biomarker abnormalities in the adult children study","volume":"68","author":"Xiong","year":"2011","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150897_ref38","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1212\/WNL.0b013e3182735c9c","article-title":"Effects of APOE on brain white matter microstructure in healthy adults","volume":"79","author":"Westlye","year":"2012","journal-title":"Neurology"},{"key":"10.3233\/JAD-150897_ref39","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","article-title":"Diffusion tensor imaging of the brain","volume":"4","author":"Alexander","year":"2007","journal-title":"Neurotheraputics"},{"key":"10.3233\/JAD-150897_ref40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system - a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed"},{"key":"10.3233\/JAD-150897_ref41","doi-asserted-by":"crossref","first-page":"e37720","DOI":"10.1371\/journal.pone.0037720","article-title":"CSF T-Tau\/A\u03b242 predicts white matter microstructure in healthy adults at risk for Alzheimer\u2019s disease","volume":"7","author":"Bendlin","year":"2012","journal-title":"PLoS One"},{"key":"10.3233\/JAD-150897_ref42","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/cercor\/bhp279","article-title":"Brain atrophy in healthy aging is related to CSF levels of A\u03b21-42","volume":"20","author":"Fjell","year":"2010","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-150897_ref43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.24186","article-title":"Cerebrospinal fluid \u03b2-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease: CSF \u03b2-amyloid and p-Tau in AD","volume":"76","author":"Fortea","year":"2014","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150897_ref44","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neurobiolaging.2013.08.027","article-title":"Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults","volume":"35","author":"Mattsson","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ana.21559","article-title":"Decreased cerebrospinal fluid A\u03b2 42 correlates with brain atrophy in cognitively normal elderly","volume":"65","author":"Fagan","year":"2009","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150897_ref46","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archneur.1994.00540210073015","article-title":"A validation study of the dementia questionnaire","volume":"51","author":"Kawas","year":"1994","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150897_ref47","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.3233\/JAD-150897_ref48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150897_ref49","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/jamaneurol.2014.1358","article-title":"Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid \u03b2-amyloid 42: A cross-validation study against amyloid positron emission tomography","volume":"71","author":"Palmqvist","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-150897_ref50","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.nicl.2014.04.008","article-title":"White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer\u2019s disease","volume":"4","author":"Adluru","year":"2014","journal-title":"Neuroimage Clin"},{"key":"10.3233\/JAD-150897_ref51","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-150897_ref52","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neurobiolaging.2013.10.072","article-title":"Regional white matter hyperintensities: Aging, Alzheimer\u2019s disease risk, and cognitive function","volume":"35","author":"Birdsill","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref53","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.neuroimage.2010.01.064","article-title":"A robust method to estimate the intracranial volume across MRI field strengths (1.5T and 3T)","volume":"50","author":"Keihaninejad","year":"2010","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-150897_ref54","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroimage.2011.02.046","article-title":"A Bayesian model of shape and appearance for subcortical brain segmentation","volume":"56","author":"Patenaude","year":"2011","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-150897_ref55","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neuroimage.2004.01.041","article-title":"Nonstationary cluster-size inference with random field and permutation methods","volume":"22","author":"Hayasaka","year":"2004","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-150897_ref56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1097-0193(1999)8:2\/3<98::AID-HBM5>3.0.CO;2-F","article-title":"Detecting changes in nonisotropic images","volume":"8","author":"Worsley","year":"1999","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-150897_ref57","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150897_ref58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1440-1819.1997.tb02375.x","article-title":"Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer\u2019s disease","volume":"51","author":"Ishizuka","year":"1997","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.3233\/JAD-150897_ref59","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.4049\/jimmunol.157.3.1213","article-title":"Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1\/JE in monocytes and microglial cells","volume":"157","author":"Meda","year":"1996","journal-title":"J Immunol"},{"key":"10.3233\/JAD-150897_ref60","doi-asserted-by":"crossref","first-page":"e30525","DOI":"10.1371\/journal.pone.0030525","article-title":"CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer\u2019s disease","volume":"7","author":"Westin","year":"2012","journal-title":"PloS One"},{"key":"10.3233\/JAD-150897_ref61","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.neuroimage.2010.12.008","article-title":"DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer\u2019s disease","volume":"55","author":"Douaud","year":"2011","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-150897_ref62","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.neurobiolaging.2010.10.015","article-title":"First transgenic rat model developing progressive cortical neurofibrillary tangles","volume":"33","author":"Filipcik","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(00)01037-5","article-title":"Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer\u2019s disease","volume":"285","author":"Sheffield","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150897_ref64","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1001\/jamaneurol.2015.1285","article-title":"Longitudinal cerebrospinal fluid biomarker changes in preclinical Alzheimer disease during middle age","volume":"72","author":"Sutphen","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-150897_ref65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-3-7091-6467-9_12","article-title":"The cytoskeleton in Alzheimer disease","volume":"53","author":"Terry","year":"1998","journal-title":"J Neural Transm Suppl"},{"key":"10.3233\/JAD-150897_ref66","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1001\/archneur.64.2.185","article-title":"Neuronal damage in brain inflammation","volume":"64","author":"Aktas","year":"2007","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150897_ref67","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.arcmed.2012.10.012","article-title":"Role of tau protein in neuronal damage in Alzheimer\u2019s disease and Down syndrome","volume":"43","author":"C\u00e1rdenas","year":"2012","journal-title":"Arch Med Res"},{"key":"10.3233\/JAD-150897_ref68","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.neurobiolaging.2003.04.007","article-title":"Clogging of s by tau, inhibition of axonal traffic and starvation of synapses","volume":"24","author":"Mandelkow","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150897_ref69","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molmed.2005.02.009","article-title":"Alzheimer\u2019s disease: A\u03b2, tau and synaptic dysfunction","volume":"11","author":"LaFerla","year":"2005","journal-title":"Trends Mol Med"},{"key":"10.3233\/JAD-150897_ref70","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1385\/MN:24:1-3:087","article-title":"CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer\u2019s disease","volume":"24","author":"Blennow","year":"2001","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-150897_ref71","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(00)01697-9","article-title":"Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke","volume":"297","author":"Hesse","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150897_ref72","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/brain\/awt065","article-title":"Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer\u2019s disease","volume":"136","author":"Ryan","year":"2013","journal-title":"Brain"},{"key":"10.3233\/JAD-150897_ref73","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.nicl.2014.02.001","article-title":"Associations between white matter microstructure and amyloid burden in preclinical Alzheimer\u2019s disease: A multimodal imaging investigation","volume":"4","author":"Racine","year":"2014","journal-title":"Neuroimage Clin"},{"key":"10.3233\/JAD-150897_ref74","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12035-013-8418-6","article-title":"Voxel-based diffusion tensor imaging of an APP\/PS1 mouse model of Alzheimer\u2019s disease","volume":"48","author":"Shu","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-150897_ref75","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: An updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150897_ref76","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer\u2019s disease in the presenilin 1 E280A kindred: A case-control study","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150897_ref77","doi-asserted-by":"crossref","first-page":"895","DOI":"10.15252\/emmm.201505026","article-title":"Increased CSF A during the very early phase of cerebral A deposition in mouse models","volume":"7","author":"Maia","year":"2015","journal-title":"EMBO Mol Med"},{"key":"10.3233\/JAD-150897_ref78","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1742-2094-2-22","article-title":"Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice","volume":"2","author":"Heneka","year":"2005","journal-title":"J Neuroinflammation"},{"key":"10.3233\/JAD-150897_ref79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1742-2094-8-77","article-title":"CCL2\/MCP-1 modulation of microglial activation and proliferation","volume":"8","author":"Hinojosa","year":"2011","journal-title":"J Neuroinflammation"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-150897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:05Z","timestamp":1777370525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-150897"}},"subtitle":[],"editor":[{"given":"Mark","family":"Bondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":79,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-150897","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}