{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:00:57Z","timestamp":1791594057155,"version":"4.3.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,5,10]]},"DOI":"10.3233\/jad-150977","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T11:40:54Z","timestamp":1463139654000},"page":"747-756","source":"Crossref","is-referenced-by-count":63,"title":["Homocysteine and Alzheimer\u2019s Disease: Evidence for a Causal Link from Mendelian Randomization"],"prefix":"10.1177","volume":"52","author":[{"given":"Qingting","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150977_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a006239","article-title":"Epidemiology of Alzheimer disease","volume":"2","author":"Mayeux","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.3233\/JAD-150977_ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2014.11.049","article-title":"The MTHFR C677T polymorphism contributes to increased risk of Alzheimer\u2019s disease: Evidence based on 40 case-control studies","volume":"586","author":"Peng","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150977_ref3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3233\/JAD-150140","article-title":"Associations between homocysteine, folic acid, vitamin B12 and Alzheimer\u2019s disease: Insights from meta-analyses","volume":"46","author":"Shen","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-150977_ref4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/JGP.0b013e3181f17eed","article-title":"Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression","volume":"19","author":"Ho","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-150977_ref5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.archger.2008.03.009","article-title":"Hyperhomocysteinemia and Alzheimer\u2019s disease: A systematic review","volume":"48","author":"Van Dama","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"key":"10.3233\/JAD-150977_ref6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3945\/ajcn.113.076349","article-title":"Effects of homocysteine lowering with B vitamins on cognitive aging: Meta-analysis of 11 trials with cognitive data on 22, 000 individuals","volume":"100","author":"Clarke","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.3233\/JAD-150977_ref7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/1471-2458-14-643","article-title":"Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta-analysis","volume":"14","author":"Beydoun","year":"2014","journal-title":"BMC Public Health"},{"key":"10.3233\/JAD-150977_ref8","doi-asserted-by":"crossref","first-page":"e1001177","DOI":"10.1371\/journal.pmed.1001177","article-title":"Homocysteine and coronary heart disease: Meta-analysis of MTHFR case-control studies, avoiding publication bias","volume":"9","author":"Clarke","year":"2012","journal-title":"PLoS Med"},{"key":"10.3233\/JAD-150977_ref9","doi-asserted-by":"crossref","first-page":"e1001462","DOI":"10.1371\/journal.pmed.1001462","article-title":"Serum iron levels and the risk of Parkinson disease: A Mendelian randomization study","volume":"10","author":"Pichler","year":"2013","journal-title":"PLoS Med"},{"key":"10.3233\/JAD-150977_ref10","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.2337\/db13-0128","article-title":"Mendelian randomisation studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes","volume":"62","author":"Yaghootkar","year":"2013","journal-title":"Diabetes"},{"key":"10.3233\/JAD-150977_ref11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3945\/ajcn.112.044545","article-title":"Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease","volume":"98","author":"van Meurs","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.3233\/JAD-150977_ref12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.ki.5002374","article-title":"Age-and gender-specific reference values of estimated GFR in Caucasians: The Nijmegen Biomedical Study","volume":"72","author":"Wetzels","year":"2007","journal-title":"Kidney Int"},{"key":"10.3233\/JAD-150977_ref13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The cardiovascular health study: Design and rationale","volume":"1","author":"Fried","year":"1991","journal-title":"Ann Epidemiol"},{"key":"10.3233\/JAD-150977_ref14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2261-8-6","article-title":"The CoLaus study: A population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome","volume":"8","author":"Firmann","year":"2008","journal-title":"BMC Cardiovasc Disord"},{"key":"10.3233\/JAD-150977_ref15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10654-011-9610-5","article-title":"The Rotterdam Study: 2012 objectives and design update","volume":"26","author":"Hofman","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"10.3233\/JAD-150977_ref16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1373\/clinchem.2007.099366","article-title":"Rationale, design, and methodology of the Women\u2019s Genome Health Study: A genome-wide association study of more than 25, 000 initially healthy American women","volume":"54","author":"Ridker","year":"2008","journal-title":"Clin Chem"},{"key":"10.3233\/JAD-150977_ref17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2009.02.011","article-title":"Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations","volume":"84","author":"Tanaka","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.3233\/JAD-150977_ref18","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/hmg\/ddp428","article-title":"Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway","volume":"18","author":"Hazra","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-150977_ref19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1375\/twin.4.6.464","article-title":"Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women","volume":"4","author":"Andrew","year":"2001","journal-title":"Twin Res"},{"key":"10.3233\/JAD-150977_ref20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.annepidem.2006.02.001","article-title":"Estimation of bias in nongenetic observational studies using \u201cmendelian triangulation\u201d","volume":"16","author":"Bautista","year":"2006","journal-title":"Ann Epidemiol"},{"key":"10.3233\/JAD-150977_ref21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.annepidem.2006.12.005","article-title":"Re: Estimation of bias in nongenetic observational studies using \u201cMendelian triangulation\u201d by Bautista et al","volume":"17","author":"Thomas","year":"2007","journal-title":"Ann Epidemiol"},{"key":"10.3233\/JAD-150977_ref22","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/jnnp.2003.025866","article-title":"Association of IL-1 RN* 2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer\u2019s disease","volume":"75","author":"Bosco","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-150977_ref23","unstructured":"Rai V (2015) Folate pathway gene methylenetetrahydrofolate reductase C677T polymorphism and Alzheimer disease risk in Asian population. Indian J Clin Biochem, 10.1007\/s12291-015-0512-2."},{"key":"10.3233\/JAD-150977_ref24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neures.2010.06.011","article-title":"Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to Alzheimer\u2019s disease","volume":"68","author":"Zhang","year":"2010","journal-title":"Neurosci Res"},{"key":"10.3233\/JAD-150977_ref25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3109\/00207454.2011.578778","article-title":"Association between the MTHFR gene and Alzheimer\u2019s disease: A meta-analysis","volume":"121","author":"Hua","year":"2011","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-150977_ref26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1479-8301.2003.00032.x","article-title":"C677T polymorphism of methylenetetrahydrofolate reductase gene affects plasma homocysteine level and is a genetic factor of late-onset Alzheimer\u2019s disease","volume":"4","author":"Kida","year":"2004","journal-title":"Psychogeriatrics"},{"key":"10.3233\/JAD-150977_ref27","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.clineuro.2013.03.015","article-title":"Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer\u2019s disease","volume":"115","author":"Mansouri","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"10.3233\/JAD-150977_ref28","first-page":"15","article-title":"Relationship between folate, vitamin B12, plasma homocysteine levels and polymorphisms of MTHFR gene in Alzheimer\u2019s disease","volume":"14","author":"Bi","year":"2004","journal-title":"China J Modern Med"},{"key":"10.3233\/JAD-150977_ref29","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.neurobiolaging.2007.12.010","article-title":"Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer\u2019s disease","volume":"30","author":"Bi","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150977_ref30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3940(01)02316-3","article-title":"The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer\u2019s disease","volume":"315","author":"Brunelli","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150977_ref31","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/01.STR.29.7.1401","article-title":"ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer\u2019s dementia","volume":"29","author":"Chapman","year":"1998","journal-title":"Stroke"},{"key":"10.3233\/JAD-150977_ref32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2011.4368","article-title":"Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer\u2019s disease patients and healthy controls","volume":"17","author":"Copped\u00e8","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.3233\/JAD-150977_ref33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1590\/S0004-282X2006000600010","article-title":"Alzheimer\u2019s disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphism","volume":"64","author":"da Silva","year":"2006","journal-title":"Arq Neuropsiquiatr"},{"key":"10.3233\/JAD-150977_ref34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.55782\/ane-2007-1639","article-title":"Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer\u2019s and Parkinson\u2019s disease","volume":"67","author":"Dorszewska","year":"2007","journal-title":"Acta Neurobiol Exp"},{"key":"10.3233\/JAD-150977_ref35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1155\/2013\/524106","article-title":"The MTHFR 677T allele may influence the severity and biochemical risk factors of Alzheimer\u2019s disease in an Egyptian population","volume":"35","author":"Elhawary","year":"2013","journal-title":"Dis Markers"},{"key":"10.3233\/JAD-150977_ref36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12017-011-8148-8","article-title":"The 894G>T (Glu298Asp) variant in the endothelial NOS gene and MTHFR polymorphisms influence homocysteine levels in patients with cognitive decline","volume":"13","author":"Ferlazzo","year":"2011","journal-title":"Neuromolecular Med"},{"key":"10.3233\/JAD-150977_ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0004-282X2005000100001","article-title":"Is MTHFR polymorphism a risk factor for Alzheimer\u2019s disease like APOE?","volume":"63","author":"Fernandez","year":"2005","journal-title":"Arq Neuropsiquiatr"},{"key":"10.3233\/JAD-150977_ref38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000191203","article-title":"Genetic analysis of Alzheimer\u2019s disease in the Uppsala Longitudinal Study of Adult Men","volume":"27","author":"Giedraitis","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-150977_ref39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/gps.1903","article-title":"Methylenetetrahydrofolate reductase gene and risk of Alzheimer\u2019s disease in Koreans","volume":"23","author":"Kim","year":"2008","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-150977_ref40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000204766","article-title":"Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer\u2019s disease risk","volume":"27","author":"Li","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-150977_ref41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ajmg.a.30295","article-title":"Lack of genetic dispositions to hyperhomocysteinemia in Alzheimer disease","volume":"131","author":"Linnebank","year":"2004","journal-title":"Am J Med Genet A"},{"key":"10.3233\/JAD-150977_ref42","doi-asserted-by":"crossref","first-page":"1003 e1001","DOI":"10.1016\/j.neurobiolaging.2011.09.018","article-title":"MTHFR (677 and 1298) and IL-6-174 G\/C genes in pathogenesis of Alzheimer\u2019s and vascular dementia and their epistatic interaction","volume":"33","author":"Mansoori","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150977_ref43","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.STR.0000032550.90046.38","article-title":"Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland","volume":"33","author":"McIlroy","year":"2002","journal-title":"Stroke"},{"key":"10.3233\/JAD-150977_ref44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2188\/jea.10.163","article-title":"Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia\u2013an epidemiological study using the polymerase chain reaction (PCR) method","volume":"10","author":"Nishiyama","year":"1999","journal-title":"J Epidemiol"},{"key":"10.3233\/JAD-150977_ref45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1532-5415.2000.tb04725.x","article-title":"The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia","volume":"48","author":"Pollak","year":"2000","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-150977_ref46","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000052822","article-title":"Plasma folate, vitamin B (12), and total homocysteine and homozygosity for the C677T mutation of the 5, 10-methylene tetrahydrofolate reductase gene in patients with Alzheimer\u2019s dementia. A case-control study","volume":"47","author":"Postiglione","year":"2001","journal-title":"Gerontology"},{"key":"10.3233\/JAD-150977_ref47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/sj.ejhg.5200651","article-title":"Lack of replication of association findings in complex disease: An analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer\u2019s disease","volume":"9","author":"Prince","year":"2001","journal-title":"Eur J Hum Genet"},{"key":"10.3233\/JAD-150977_ref48","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000070677","article-title":"Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer\u2019s disease and mild cognitive impairment","volume":"16","author":"Religa","year":"2003","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-150977_ref49","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0197-4580(03)00040-X","article-title":"Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients","volume":"24","author":"Seripa","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150977_ref50","first-page":"249","article-title":"Association between genetic and environmental factors and the risk of Alzheimer\u2019s disease","volume":"46","author":"Styczy\u0144ska","year":"2008","journal-title":"Folia Neuropathol"},{"key":"10.3233\/JAD-150977_ref51","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1749-6632.2002.tb04820.x","article-title":"Genetic analysis of vascular factors in Alzheimer\u2019s disease","volume":"977","author":"Wakutani","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.3233\/JAD-150977_ref52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/JMN:27:1:023","article-title":"Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer\u2019s disease","volume":"27","author":"Wang","year":"2005","journal-title":"J Mol Neurosci"},{"key":"10.3233\/JAD-150977_ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000092845","article-title":"Differences in risk factors for dementia with neurodegenerative traits and for vascular dementia","volume":"22","author":"Wehr","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-150977_ref54","first-page":"247","article-title":"Relationship of homocysteine and gene polymorphisms of its related metabolic enzymes with Alzheimer\u2019s disease","volume":"20","author":"Zhang","year":"2005","journal-title":"Chin Med Sci J"},{"key":"10.3233\/JAD-150977_ref55","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1034\/j.1600-0404.2001.103005304.x","article-title":"Genetic polymorphisms in older subjects with Vascular or Alzheimer\u2019s dementia","volume":"103","author":"Zuliani","year":"2001","journal-title":"Acta Neurol Scand"},{"key":"10.3233\/JAD-150977_ref56","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4103\/0972-2327.138510","article-title":"Intergenotypic variation of vitamin B12 and folate in AD: In North Indian population","volume":"17","author":"Chhillar","year":"2014","journal-title":"Ann Indian Acad Neurol"},{"key":"10.3233\/JAD-150977_ref57","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s11064-006-9119-6","article-title":"C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer\u2019s disease in Iranian population","volume":"31","author":"Keikhaee","year":"2006","journal-title":"Neurochem Res"},{"key":"10.3233\/JAD-150977_ref58","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00001756-200404090-00025","article-title":"Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer\u2019s disease","volume":"15","author":"Anello","year":"2004","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-150977_ref59","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2174\/1567205012666141218144035","article-title":"Associations between Alzheimer\u2019s disease and blood homocysteine, vitamin B12, and folate: A case-control study","volume":"12","author":"Chen","year":"2015","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-150977_ref60","first-page":"4446","article-title":"Relationship between increase of serum homocysteine caused by smoking and oxidative damage in elderly patients with cardiovascular disease","volume":"8","author":"Chen","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.3233\/JAD-150977_ref61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/jmedgenet-2014-102438","article-title":"Mendelian randomisation applied to drug development in cardiovascular disease: A review","volume":"52","author":"Mokry","year":"2015","journal-title":"J Med Genet"},{"key":"10.3233\/JAD-150977_ref62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/1874205X01509010009","article-title":"Homocysteine induced cerebrovascular dysfunction: A link to Alzheimer\u2019s disease etiology","volume":"9","author":"Kamat","year":"2015","journal-title":"Open Neurol J"},{"key":"10.3233\/JAD-150977_ref63","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s11239-012-0856-x","article-title":"Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer\u2019s disease","volume":"36","author":"Cacciapuoti","year":"2013","journal-title":"J Thromb Thrombolysis"},{"key":"10.3233\/JAD-150977_ref64","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat Med"},{"key":"10.3233\/JAD-150977_ref65","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/jnci\/92.14.1151","article-title":"Population stratification in epidemiologic studies of common genetic variants and cancer: Quantification of bias","volume":"92","author":"Wacholder","year":"2000","journal-title":"J Natl Cancer Inst"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-150977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:39Z","timestamp":1777370559000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-150977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,10]]},"references-count":65,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-150977","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,10]]}}}