{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:57:47Z","timestamp":1790218667601,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,8,3]]},"DOI":"10.3233\/jad-150987","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T11:35:57Z","timestamp":1470310557000},"page":"1097-1105","source":"Crossref","is-referenced-by-count":55,"title":["Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly"],"prefix":"10.1177","volume":"53","author":[{"given":"David C.","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Psychiatry, Mercy Medical Group, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Harvard Aging Brain Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Mormino","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Amariglio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorene M.","family":"Rentz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad A.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150987_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13539-012-0059-5","article-title":"The obesity paradox in chronic disease: Facts and numbers","volume":"3","author":"Lainscak","year":"2012","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.3233\/JAD-150987_ref2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1136\/bmj.38446.466238.E0","article-title":"Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study","volume":"330","author":"Whitmer","year":"2005","journal-title":"BMJ"},{"key":"10.3233\/JAD-150987_ref3","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182190d09","article-title":"Midlife overweight and obesity increase late-life dementia risk: A population-based twin study","volume":"76","author":"Xu","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1532-5415.2007.01458.x","article-title":"Late-life body mass index and dementia incidence: Nine-year follow-up data from the Kungsholmen Project","volume":"56","author":"Atti","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-150987_ref5","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1212\/WNL.0b013e3181a60a58","article-title":"Association between late-life body mass index and dementia: The Kame Project","volume":"72","author":"Hughes","year":"2009","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1532-5415.2005.00522.x","article-title":"Cognitive function in normal-weight, overweight, and obese older adults: An analysis of the Advanced Cognitive Training for Independent and Vital Elderly cohort","volume":"54","author":"Kuo","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-150987_ref7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/WAD.0000000000000005","article-title":"Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease","volume":"28","author":"Besser","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-150987_ref8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02982565","article-title":"Body mass index, dementia, and mortality in the elderly","volume":"12","author":"Luchsinger","year":"2008","journal-title":"J Nutr Health Aging"},{"key":"10.3233\/JAD-150987_ref9","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1212\/01.wnl.0000176061.33817.90","article-title":"Change in body mass index and risk of incident Alzheimer disease","volume":"65","author":"Buchman","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/archneur.63.9.1312","article-title":"Accelerated weight loss may precede diagnosis in Alzheimer disease","volume":"63","author":"Johnson","year":"2006","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150987_ref11","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1212\/01.wnl.0000267661.65586.33","article-title":"Incident dementia in women is preceded by weight loss by at least a decade","volume":"69","author":"Knopman","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/archneur.62.1.55","article-title":"A 32-year prospective study of change in body weight and incident dementia: The Honolulu-Asia Aging Study","volume":"62","author":"Stewart","year":"2005","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150987_ref13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1532-5415.1998.tb04537.x","article-title":"The association of weight change in Alzheimer\u2019s disease with severity of disease and mortality: A longitudinal analysis","volume":"46","author":"White","year":"1998","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-150987_ref14","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1212\/01.wnl.0000247046.90574.0f","article-title":"Body mass index in older persons is associated with Alzheimer disease pathology","volume":"67","author":"Buchman","year":"2006","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref15","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1212\/WNL.46.6.1585","article-title":"Low body weight in Alzheimer\u2019s disease is associated with mesial temporal cortex atrophy","volume":"46","author":"Grundman","year":"1996","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref16","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.neurobiolaging.2011.05.005","article-title":"Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer\u2019s disease","volume":"33","author":"Ewers","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150987_ref17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jalz.2011.08.008","article-title":"Cardiovascular risk factors, cortisol, and amyloid-beta deposition in Alzheimer\u2019s disease neuroimaging initiative","volume":"8","author":"Toledo","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150987_ref18","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1212\/WNL.0b013e318238eec1","article-title":"Alzheimer disease biomarkers are associated with body mass index","volume":"77","author":"Vidoni","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/WAD.0000000000000013","article-title":"Gene-environment interaction of body mass index and apolipoprotein E epsilon4 allele on cognitive decline","volume":"28","author":"Rajan","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-150987_ref20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1212\/WNL.56.5.655","article-title":"APOE-epsilon4 is associated with weight loss in women with AD: A population-based study","volume":"56","author":"Vanhanen","year":"2001","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref21","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150987_ref22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1212\/WNL.0000000000000431","article-title":"Amyloid and APOE \u025b4 interact to influence short-term decline in preclinical Alzheimer disease","volume":"82","author":"Mormino","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref23","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jamaneurol.2014.2031","article-title":"Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals","volume":"71","author":"Mormino","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-150987_ref24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1474-4422(13)70194-7","article-title":"Preclinical Alzheimer\u2019s disease and its outcome: A longitudinal cohort study","volume":"12","author":"Vos","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150987_ref25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/jamaneurol.2015.3098","article-title":"Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community","volume":"73","author":"Petersen","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-150987_ref26","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): Current version and scoring rules.[see comment]","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-150987_ref28","volume-title":"WMS-R: Weschler Memory Scale - Revised Manual","author":"Weschler","year":"1987"},{"issue":"(Suppl 2)","key":"10.3233\/JAD-150987_ref29","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1161\/01.cir.0000437739.71477.ee","article-title":"2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and The Obesity Society","volume":"129","author":"Jensen","year":"2014","journal-title":"Circulation"},{"key":"10.3233\/JAD-150987_ref30","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ana.22333","article-title":"Amyloid-beta associated cortical thinning in clinically normal elderly","volume":"69","author":"Becker","year":"2011","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150987_ref31","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1523\/JNEUROSCI.2462-12.2012","article-title":"Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults","volume":"32","author":"Hedden","year":"2012","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-150987_ref32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ana.21164","article-title":"Imaging of amyloid burden and distribution in cerebral amyloid angiopathy","volume":"62","author":"Johnson","year":"2007","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150987_ref33","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer\u2019s disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150987_ref34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11910-996-0018-7","article-title":"Olfactory dysfunction as a predictor of neurodegenerative disease","volume":"6","author":"Albers","year":"2006","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.3233\/JAD-150987_ref35","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1212\/WNL.0000000000001614","article-title":"Odor identification and Alzheimer disease biomarkers in clinically normal elderly","volume":"84","author":"Growdon","year":"2015","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1212\/01.wnl.0000324864.81179.6a","article-title":"Physical frailty in older persons is associated with Alzheimer disease pathology","volume":"71","author":"Buchman","year":"2008","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref37","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1212\/WNL.0b013e318294b462","article-title":"Association of brain pathology with the progression of frailty in older adults","volume":"80","author":"Buchman","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref38","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s12603-013-0367-2","article-title":"Cognitive frailty: Rational and definition from an (I.A.N.A.\/I.A.G.G.) international consensus group","volume":"17","author":"Kelaiditi","year":"2013","journal-title":"J Nutr Health Aging"},{"key":"10.3233\/JAD-150987_ref39","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1212\/WNL.53.9.1998","article-title":"The occurrence of depressive symptoms in the preclinical phase of AD: A population-based study","volume":"53","author":"Berger","year":"1999","journal-title":"Neurology"},{"key":"10.3233\/JAD-150987_ref40","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1111\/j.1532-5415.2011.03664.x","article-title":"Depression is associated with sarcopenia, not central obesity, in elderly Korean men","volume":"59","author":"Kim","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-150987_ref41","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11065-014-9267-4","article-title":"The relevance of beta-amyloid on markers of Alzheimer\u2019s disease in clinically normal individuals and factors that influence these associations","volume":"24","author":"Mormino","year":"2014","journal-title":"Neuropsychol Rev"},{"key":"10.3233\/JAD-150987_ref42","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archneurol.2010.38","article-title":"Reduced lean mass in early Alzheimer disease and its association with brain atrophy","volume":"67","author":"Burns","year":"2010","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150987_ref43","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1474-4422(06)70526-9","article-title":"Adiposity indices and dementia","volume":"5","author":"Gustafson","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150987_ref44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1532-5415.2010.03219.x","article-title":"Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: Results from the Women\u2019s Health Initiative Memory Study","volume":"59","author":"Kerwin","year":"2011","journal-title":"J Am Geriatr Soc"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-150987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:03:05Z","timestamp":1777370585000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-150987"}},"subtitle":[],"editor":[{"given":"Duygu","family":"Tosun-Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":44,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-150987","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}