{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:04:22Z","timestamp":1792008262241,"version":"4.4.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,4,12]]},"abstract":"<jats:p>\n                    Uncoupling proteins (UCPs) are a group of five mitochondrial inner membrane transporters with a tissue specific expression that uncouple biofuel oxidation from ATP synthesis and function as regulators of energy homeostasis and antioxidants. Previous data suggested that neuronal UCPs (UCP2, UCP4, and UCP5) can directly influence synaptic plasticity, neurotransmission, and neurodegenerative processes, and have a crucial role in the function and protection of the central nervous system. In fact, it has been observed that the expression of neuronal UCPs significantly decreases in Alzheimer\u2019s disease (AD) patients. Here we analyzed the variability of\n                    <jats:italic>UCP2<\/jats:italic>\n                    , -\n                    <jats:italic>3<\/jats:italic>\n                    , -\n                    <jats:italic>4<\/jats:italic>\n                    , and\n                    <jats:italic>5<\/jats:italic>\n                    genes in sporadic and familial cases (\n                    <jats:italic>n<\/jats:italic>\n                    \u200a=\u200a465) of late-onset AD (LOAD) with respect to healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u200a=\u200a442). We showed that a genetic variant in the human\n                    <jats:italic>UCP4<\/jats:italic>\n                    , rs9472817, not only significantly affects the individual susceptibility to LOAD, but also modulates the effect of\n                    <jats:italic>APOE<\/jats:italic>\n                    -\n                    <jats:italic>\u025b4<\/jats:italic>\n                    on AD risk. In fact, rs9472817-C allele was significantly more frequent in both groups of patients with respect to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u200a=\u200a6.934\n                    <jats:sup>*<\/jats:sup>\n                    10\n                    <jats:sup>\u20134<\/jats:sup>\n                    for familial and\n                    <jats:italic>p<\/jats:italic>\n                    \u200a=\u200a1.033\n                    <jats:sup>*<\/jats:sup>\n                    10\n                    <jats:sup>\u20133<\/jats:sup>\n                    for sporadic cases). In addition, gene-gene interaction analysis revealed that the effect of APOE-\n                    <jats:italic>\u025b<\/jats:italic>\n                    4 allele on LOAD risk was doubled in homozygote CC subjects; conversely, the risk conferred by the APOE-\n                    <jats:italic>\u025b<\/jats:italic>\n                    4 allele was annulled in subjects with two copies of the G allele. Our findings are further evidence that the efficiency in mitochondrial energy metabolism and oxidative stress are important factors in AD pathogenesis.\n                  <\/jats:p>","DOI":"10.3233\/jad-150993","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T12:09:12Z","timestamp":1460462952000},"page":"1265-1274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer\u2019s Disease and Modifies the Disease\u2019s Risk in APOE-\n                    <i>\u025b<\/i>\n                    4 Carriers"],"prefix":"10.1177","volume":"51","author":[{"given":"Alberto","family":"Montesanto","sequence":"first","affiliation":[{"name":"Department of Biology, Ecology and Earth Science, University of Calabria, Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolina","family":"Crocco","sequence":"additional","affiliation":[{"name":"Department of Biology, Ecology and Earth Science, University of Calabria, Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Anfossi","sequence":"additional","affiliation":[{"name":"Regional Neurogenetic Centre, ASP CZ, Lamezia Terme (CZ), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Smirne","sequence":"additional","affiliation":[{"name":"Regional Neurogenetic Centre, ASP CZ, Lamezia Terme (CZ), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Puccio","sequence":"additional","affiliation":[{"name":"Regional Neurogenetic Centre, ASP CZ, Lamezia Terme (CZ), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Colao","sequence":"additional","affiliation":[{"name":"Regional Neurogenetic Centre, ASP CZ, Lamezia Terme (CZ), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Maletta","sequence":"additional","affiliation":[{"name":"Regional Neurogenetic Centre, ASP CZ, Lamezia Terme (CZ), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Passarino","sequence":"additional","affiliation":[{"name":"Department of Biology, Ecology and Earth Science, University of Calabria, Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia C.","family":"Bruni","sequence":"additional","affiliation":[{"name":"Regional Neurogenetic Centre, ASP CZ, Lamezia Terme (CZ), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Biology, Ecology and Earth Science, University of Calabria, Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000228136.58062.bf"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.007"},{"key":"e_1_3_3_6_2","first-page":"570","article-title":"Alzheimer\u2019s disease: Diverse aspects of mitochondrial malfunctioning","volume":"3","author":"Santos RX","year":"2010","unstructured":"SantosRX, CorreiaSC, WangX, PerryG, SmithMA, MoreiraPI, ZhuX (2010) Alzheimer\u2019s disease: Diverse aspects of mitochondrial malfunctioning. 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