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However, they cannot fully explain specific patterns of retrograde amnesia in AD. In the current study we examined an alternative approach and investigated whether the extent and severity of retrograde amnesia in AD is mediated by the frequency of memory retrieval or whether it depends on the mere age of knowledge. We compared recall of autobiographical incidents from three life periods in patients with amnestic mild cognitive impairment (aMCI), patients with early dementia of Alzheimer type (eDAT), and healthy control (HC) individuals using the Autobiographical Memory Interview. Retrieval frequency was operationalized by a paired comparison analysis. In contrast to HC individuals, recall of autobiographical incidents was impaired in patients with aMCI and eDAT following Ribot\u2019s gradient, with a reduced memory loss for remote compared to more recent life events. However, there was a strong effect of retrieval frequency on memory performance with frequently retrieved incidents memorized in more detail than less frequently retrieved episodes. Remote memories were recalled more often than recent ones. These findings suggest that more frequently retrieved autobiographical memories generally become more independent of the hippocampal complex and might thus be better protected against early hippocampal damage related to AD. Hence, the extent of retrograde amnesia in AD appears mainly mediated by the frequency of memory retrieval, which could plausibly explain why cognitive activity can effectively delay the onset of memory decline in AD.<\/jats:p>","DOI":"10.3233\/jad-151071","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T13:44:30Z","timestamp":1465566270000},"page":"1215-1225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Autobiographical Memory Performance in Alzheimer\u2019s Disease Depends on Retrieval Frequency"],"prefix":"10.1177","volume":"52","author":[{"given":"Stephan","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Eberhard Karls University, T\u00fcbingen, Germany"},{"name":"Geriatric Center at the University Hospital, Eberhard Karls University, T\u00fcbingen, 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