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Consequently, we have examined quantitative changes in both \u03b2-secretase and amyloid-\u03b2 protein precursor genes in the medial temporal lobe cortex with the use of quantitative rtPCR analysis following 10-min global brain ischemia in rats with survival of 2, 7, and 30 days. The greatest significant overexpression of \u03b2-secretase gene was noted on the 2nd day, while on days 7\u201330 the expression of this gene was only modestly downregulated. Amyloid-\u03b2 protein precursor gene was downregulated on the 2nd day, but on days 7\u201330 postischemia, there was a significant reverse tendency. Thus, the demonstrated alterations indicate that the considerable changes of expression of \u03b2-secretase and amyloid-\u03b2 protein precursor genes may be connected with a response of neurons in medial temporal lobe cortex to transient global brain ischemia. Finally, the ischemia-induced gene changes may play a key role in a late and slow onset of Alzheimer-type pathology.<\/jats:p>","DOI":"10.3233\/jad-151102","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T12:09:26Z","timestamp":1460462966000},"page":"1023-1031","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Discrepancy in Expression of \u03b2-Secretase and Amyloid-\u03b2 Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia"],"prefix":"10.1177","volume":"51","author":[{"given":"Ryszard","family":"Pluta","sequence":"first","affiliation":[{"name":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Kocki","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"U\u0142amek-Kozio\u0142","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Petniak","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Gil-Kulik","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Januszewski","sequence":"additional","affiliation":[{"name":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Bogucki","sequence":"additional","affiliation":[{"name":"Warsaw Higher Humanistic School, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miros\u0142aw","family":"Jab\u0142o\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Orthopaedics, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judyta","family":"Brzozowska","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Furmaga-Jab\u0142o\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Neonate and Infant Pathology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bogucka-Kocka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw J.","family":"Czuczwar","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,2,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90172-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70221-0"},{"key":"e_1_3_2_4_2","first-page":"267","article-title":"Micro-blood-brain barrier openings and cytotoxic fragments of amyloid precursor protein accumulation in white matter after ischemic brain injury in long lived rats","volume":"96","author":"Pluta R","year":"2006","unstructured":"PlutaR, U\u0142amekM, JanuszewskiS (2006) Micro-blood-brain barrier openings and cytotoxic fragments of amyloid precursor protein accumulation in white matter after ischemic brain injury in long lived rats. 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