{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:00:34Z","timestamp":1789556434298,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2016,6,22]]},"DOI":"10.3233\/jad-160047","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T03:10:06Z","timestamp":1466651406000},"page":"259-272","source":"Crossref","is-referenced-by-count":66,"title":["Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1\u03b2 Synthesis in Brains of Alzheimer\u2019s Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats"],"prefix":"10.1177","volume":"53","author":[{"given":"Nirmal","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis B.","family":"Hersh","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Despa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-160047_ref1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol Rev"},{"key":"10.3233\/JAD-160047_ref2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0196-9781(98)00018-7","article-title":"Differential permeability of the blood-brain barrier to two pancreatic peptides: Insulin and amylin","volume":"19","author":"Banks","year":"1998","journal-title":"Peptides"},{"key":"10.3233\/JAD-160047_ref3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","article-title":"Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis","volume":"52","author":"Zraika","year":"2009","journal-title":"Diabetologia"},{"key":"10.3233\/JAD-160047_ref4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat Immunol"},{"key":"10.3233\/JAD-160047_ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-immunol-032414-112306","article-title":"Inflammasome-independent regulation of IL-1-family cytokines","volume":"33","author":"Netea","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"10.3233\/JAD-160047_ref6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5002305","article-title":"Amylin deposition in the kidney of patients with diabetic nephropathy","volume":"72","author":"Gong","year":"2007","journal-title":"Kidney Int"},{"key":"10.3233\/JAD-160047_ref7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCRESAHA.111.258285","article-title":"Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: A study in humans and rats","volume":"110","author":"Despa","year":"2012","journal-title":"Circ Res"},{"key":"10.3233\/JAD-160047_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.114.001015","article-title":"Cardioprotection by controlling hyperamylinemia in a humanized diabetic rat model","volume":"3","author":"Despa","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.3233\/JAD-160047_ref9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/ana.23956","volume":"74","author":"Jackson","year":"2013","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-160047_ref10","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2174\/1567205011666141107124538","article-title":"Islet amyloid polypeptide (IAPP): A second amyloid in Alzheimer\u2019s disease","volume":"11","author":"Fawver","year":"2014","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-160047_ref11","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ajpath.2014.11.016","article-title":"In vivo seeding and cross-seeding of localized amyloidosis: A molecular link between type 2 diabetes and Alzheimer disease","volume":"185","author":"Oskarsson","year":"2015","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-160047_ref12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-160047_ref13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1750-1326-9-30","article-title":"Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin","volume":"9","author":"Srodulski","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-160047_ref14","first-page":"A13963","article-title":"Hyperamylinemia, a potential therapeutic target in diabetic cardiorenal syndrom","volume":"130","author":"Srodulski","year":"2013","journal-title":"Circulation"},{"key":"10.3233\/JAD-160047_ref15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"10.3233\/JAD-160047_ref16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ilar.47.3.225","article-title":"Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes","volume":"47","author":"Matveyenko","year":"2006","journal-title":"ILAR J"},{"key":"10.3233\/JAD-160047_ref17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/mcne.2001.0972","article-title":"Beta-amyloid peptide expression is sufficient for myotube death: Implications for human inclusion body myopathy","volume":"17","author":"Querfurth","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.3233\/JAD-160047_ref18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","article-title":"The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles","volume":"48","author":"Janson","year":"1999","journal-title":"Diabetes"},{"key":"10.3233\/JAD-160047_ref19","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.1087348","article-title":"Games played by rogue proteins in prion disorders and Alzheimer\u2019s disease","volume":"302","author":"Aguzzi","year":"2003","journal-title":"Science"},{"key":"10.3233\/JAD-160047_ref20","doi-asserted-by":"crossref","first-page":"E1656","DOI":"10.1152\/ajpendo.00318.2007","article-title":"Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide","volume":"293","author":"Huang","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3233\/JAD-160047_ref21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/09298673113209990181","article-title":"4-Hydroxynonenal in the pathogenesis and progression of human diseases","volume":"21","author":"Shoeb","year":"2014","journal-title":"Curr Med Chem"},{"key":"10.3233\/JAD-160047_ref22","doi-asserted-by":"crossref","first-page":"R1782","DOI":"10.1152\/ajpregu.90635.2008","article-title":"Development and characterization of a novel rat model of type 2 diabetes mellitus: The UC Davis type 2 diabetes mellitus UCD-T2DM rat","volume":"295","author":"Cummings","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.3233\/JAD-160047_ref23","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/nprot.2006.356","article-title":"Culturing hippocampal neurons","volume":"1","author":"Kaech","year":"2006","journal-title":"Nat Protoc"},{"key":"10.3233\/JAD-160047_ref24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-291X(89)91732-4","article-title":"Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration","volume":"164","author":"Nakazato","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-160047_ref25","doi-asserted-by":"crossref","first-page":"17809","DOI":"10.1073\/pnas.1414004111","article-title":"Self-assembled FUS binds active chromatin and regulates gene transcription","volume":"111","author":"Yang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-160047_ref26","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.jchromb.2011.06.008","article-title":"The simple and sensitive measurement of malondialdehyde in selected specimens of biological origin and some feed by reversed phase high performance liquid chromatography","volume":"879","author":"Czauderna","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.3233\/JAD-160047_ref27","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.freeradbiomed.2007.01.038","article-title":"Mass spectrometric analysis demonstrates that BODIPY 581\/591 C11 overestimates and inhibits oxidative lipid damage","volume":"42","author":"MacDonald","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.3233\/JAD-160047_ref28","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1523\/JNEUROSCI.1051-04.2004","article-title":"Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons","volume":"24","author":"Jhamandas","year":"2004","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-160047_ref29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.3233\/JAD-160047_ref30","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3233\/JAD-2009-1013","article-title":"Oxidative stress in diabetes and Alzheimer\u2019s disease","volume":"16","author":"Reddy","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-160047_ref31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nbd.2015.06.013","article-title":"Oxidative stress and lipid peroxidation are upstream of amyloid pathology","volume":"84","author":"Arimon","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-160047_ref32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1021\/acschemneuro.5b00316","article-title":"Amyloid plaque-associated oxidative degradation of uniformly radiolabeled arachidonic acid","volume":"7","author":"Furman","year":"2016","journal-title":"ACS Chem Neurosci"},{"key":"10.3233\/JAD-160047_ref33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nri1664","article-title":"Interleukin-1 and neuronal injury","volume":"5","author":"Allan","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.3233\/JAD-160047_ref34","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","article-title":"Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril formation","volume":"87","author":"Westermark","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-160047_ref35","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jcpa.2014.06.004","article-title":"Oxidative modification, inflammation and amyloid in the normal and diabetic cat pancreas","volume":"151","author":"Herndon","year":"2014","journal-title":"J Comp Pathol"},{"key":"10.3233\/JAD-160047_ref36","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.bbamem.2007.01.012","article-title":"Structural and functional recovery of electropermeabilized skeletal muscle in-vivo after treatment with surfactant poloxamer 188","volume":"1768","author":"Collins","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-160047_ref37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/1872208311206030200","article-title":"Poloxamer 188 (P188) as a membrane resealing reagent in biomedical applications","volume":"6","author":"Joseph","year":"2012","journal-title":"Recent Pat Biotechnol"},{"key":"10.3233\/JAD-160047_ref38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archneurol.2009.27","article-title":"The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged","volume":"66","author":"Craft","year":"2009","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-160047_ref39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrneurol.2010.130","article-title":"How does diabetes accelerate Alzheimer disease pathology?","volume":"6","author":"Sims-Robinson","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-160047_ref40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neurobiolaging.2005.08.015","article-title":"The impact of diabetes on cognition: What can be learned from rodent models?","volume":"26","author":"Biessels","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-160047_ref41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-61779-328-8_12","article-title":"Practical considerations of genetic rodent models for neurodegenerative diseases","volume":"793","author":"Geghman","year":"2011","journal-title":"Methods Mol Biol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-160047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:57Z","timestamp":1777370577000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-160047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":41,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-160047","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}