{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:59:13Z","timestamp":1789923553388,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,6,7]]},"abstract":"<jats:p>\n                    A rapidly progressing aging society has raised attention to white matter lesions in Alzheimer\u2019s disease. In the present study, we applied an AD plus cerebral hypoperfusion (HP) mouse model and investigated the alternation of key protein molecules in the nodal, paranodal, and intermodal sites in the white matter as well as the efficacy of galantamine. Cerebral HP was induced in APP23 mice by bilateral common carotid arteries stenosis with ameroid constrictors. Compared with the wild type and simple APP23 mice, APP23 + HP mice showed a progressive loss of MAG and NF186 from 6 to 12 months, broken misdistribution of MBP, and extended relocation of Na\n                    <jats:sub>v<\/jats:sub>\n                    1.6 and AnkG beyond the primary nodal region in the corpus callosum. Such abnormal neuropathological processes were retrieved with galantamine treatment. The present study demonstrated that cerebral HP strongly disrupted white matter integrity (WMI) at intermodal, paranodal, and Ranvier\u2019s nodal sites which may be associated with cognitive decline. Galantamine treatment significantly protected such WMI probably by allosterically potentiating ligand action.\n                  <\/jats:p>","DOI":"10.3233\/jad-160120","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T13:45:36Z","timestamp":1465566336000},"page":"1311-1319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Disruption of White Matter Integrity by Chronic Cerebral Hypoperfusion in Alzheimer\u2019s Disease Mouse Model"],"prefix":"10.1177","volume":"52","author":[{"given":"Yun","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,  Okayama University, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, 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