{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:40:40Z","timestamp":1777394440016,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    There is increasing interest in DNA methylation studies in Alzheimer\u2019s disease (AD), but little is still known concerning the relationship between gene-promoter methylation and circulating biomarkers of one-carbon metabolism in patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To detect the connections among circulating folate, homocysteine (hcy) and vitamin B12 levels and promoter methylation levels of\n                    <jats:italic>PSEN1<\/jats:italic>\n                    ,\n                    <jats:italic>BACE1<\/jats:italic>\n                    ,\n                    <jats:italic>DNMT1<\/jats:italic>\n                    ,\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    ,\n                    <jats:italic>DNMT3B<\/jats:italic>\n                    , and\n                    <jats:italic>MTHFR<\/jats:italic>\n                    genes in blood DNA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We applied a data mining system called Auto Contractive Map to an existing database of 100 AD and 100 control individuals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Low vitamin B12 was linked to the AD condition, to low folates, and to high hcy. Low\n                    <jats:italic>PSEN1<\/jats:italic>\n                    methylation was linked to low folate levels as well as to low promoter methylation of\n                    <jats:italic>BACE1<\/jats:italic>\n                    and\n                    <jats:italic>DNMTs<\/jats:italic>\n                    genes. Low hcy was linked to controls, to high folates and vitamin B12, as well as to high methylation levels of most of the studied genes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The present pilot study suggests that promoter methylation levels of the studied genes are linked to circulating levels of folates, hcy, and vitamin B12.\n                  <\/jats:p>","DOI":"10.3233\/jad-160210","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T10:05:18Z","timestamp":1467713118000},"page":"1517-1522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Artificial Neural Networks Link One-Carbon Metabolism to Gene-Promoter Methylation in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"53","author":[{"given":"Enzo","family":"Grossi","sequence":"first","affiliation":[{"name":"Villa Santa Maria Institute, Tavernerio, Italy"},{"name":"Semeion Research Center of Sciences of Communication, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Stoccoro","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Pisa, Italy"},{"name":"Doctoral School in Genetics, Oncology, and Clinical Medicine, University of Siena, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaola","family":"Tannorella","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Pisa, Italy"},{"name":"Interdepartmental Research Center Nutrafood \u201cNutraceuticals and Food for Health\u201d,  University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Copped\u00e8","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Pisa, Italy"},{"name":"Interdepartmental Research Center Nutrafood \u201cNutraceuticals and Food for Health\u201d,  University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150140"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920210791233090"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.04.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.09.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.01.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161025002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.03.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720508785908928"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130956"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/728158"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150747"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.06.009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100720070075"},{"key":"e_1_3_3_16_2","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, fourth ed., American Psychiatric Association, Washington, DC."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004060050098"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.735"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.12.018"},{"key":"e_1_3_3_20_2","first-page":"1169","article-title":"Epigenetic modifications in Alzheimer\u2019s disease: Cause or effect?","volume":"43","author":"Piaceri I","year":"2015","unstructured":"PiaceriI, RaspantiB, TeddeA, BagnoliS, SorbiS, NacmiasB (2015) Epigenetic modifications in Alzheimer\u2019s disease: Cause or effect?. 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