{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:20:36Z","timestamp":1787559636172,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,11,19]]},"abstract":"<jats:p>We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer\u2019s disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.<\/jats:p>","DOI":"10.3233\/jad-160289","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T10:35:31Z","timestamp":1476441331000},"page":"797-811","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Aerosol Delivery of Curcumin Reduced Amyloid-\u03b2 Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"55","author":[{"given":"Richard","family":"McClure","sequence":"first","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Ong","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhab","family":"Janve","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Barton","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Dawes","sequence":"additional","affiliation":[{"name":"Vanderbilt Cell Imaging Core Laboratory","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gray","family":"Jerome","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Anderson","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Massion","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Gore","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"Pham","sequence":"additional","affiliation":[{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]},{"name":"Vanderbilt Institute of Chemical Biology","place":["USA"]},{"name":"Vanderbilt University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318288a8dd"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00100.Irvine"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004457"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.06.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.1997.tb11466.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600760709"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.05.022"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500279"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-015-0010-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7010306"},{"key":"e_1_3_3_12_2","first-page":"823","article-title":"Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis","volume":"65","author":"Galaly SR","year":"2014","unstructured":"GalalySR, AhmedOM, MahmoudAM (2014) Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. J Physiol Pharmacol 65, 823\u2013832.","journal-title":"J Physiol Pharmacol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.12.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124000"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.02.024"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20110043"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24548"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201500142"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-015-0366-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2015.1055570"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.10.076"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/495091"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201015666140813122703"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140798"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.04.015"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.007"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1996.tb00021.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903070308"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901500105"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00684-0"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10037"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140495"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23416"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(87)90057-8"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970324)379:4<482::AID-CNE2>3.0.CO;2-Z"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7598"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23269"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00124-X"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2868-05.2005"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(98)00013-8"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00304-9"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1978.tb02240.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240630705"},{"key":"e_1_3_3_47_2","first-page":"806","article-title":"Mechanisms of curcumin induced gastric ulcer in rats","volume":"71","author":"Gupta B","year":"1980","unstructured":"GuptaB, KulshresthaVK, SrivastavaRK, PrasadDN (1980) Mechanisms of curcumin induced gastric ulcer in rats. Indian J Med Res 71, 806\u2013814.","journal-title":"Indian J Med Res"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-160289","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:51:00Z","timestamp":1787557860000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-160289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,12]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,11,19]]}},"alternative-id":["10.3233\/JAD-160289"],"URL":"https:\/\/doi.org\/10.3233\/jad-160289","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,12]]}}}