{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:11Z","timestamp":1791270191731,"version":"4.1.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a neurodegenerative disorder represented by the accumulation of intracellular tau protein and extracellular deposits of amyloid-\u03b2 (A\u03b2) in the brain. The gene sortilin 1 (\n                    <jats:italic>SORT1<\/jats:italic>\n                    ) has previously been associated with cardiovascular disease in gene association studies. It has also been proposed to be involved in AD pathogenesis through facilitating A\u03b2 clearance by binding apoE\/A\u03b2 complexes prior to cellular uptake. However, the neuropathological role of\n                    <jats:italic>SORT1<\/jats:italic>\n                    in AD is not fully understood. To evaluate the associations between gene variants of\n                    <jats:italic>SORT1<\/jats:italic>\n                    and risk of AD, we performed genetic analyses in a Swedish case-control cohort. Ten single nucleotide polymorphisms (SNPs), covering the whole\n                    <jats:italic>SORT1<\/jats:italic>\n                    gene, were selected and genotyped in 620 AD patients and 1107 controls. The SNP rs17646665, located in a non-coding region of the\n                    <jats:italic>SORT1<\/jats:italic>\n                    gene, remained significantly associated with decreased risk of AD after multiple testing (p\n                    <jats:sub>c<\/jats:sub>\n                    \u200a=\u200a0.0061). In addition, other SNPs were found to be nominally associated with risk of AD, as well as altered cognitive function and the CSF biomarker A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    , but these associations did not survive correction for multiple testing. The fact that\n                    <jats:italic>SORT1<\/jats:italic>\n                    has been strongly associated with risk of cardiovascular disease is intriguing as cardiovascular disease is also regarded as a risk factor for AD. Finally, increased knowledge about\n                    <jats:italic>SORT1<\/jats:italic>\n                    function has a potential to increase our understanding of\n                    <jats:italic>APOE<\/jats:italic>\n                    , the strongest risk factor for AD.\n                  <\/jats:p>","DOI":"10.3233\/jad-160319","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T10:06:00Z","timestamp":1467713160000},"page":"1353-1363","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["A Genetic Variant of the Sortilin 1 Gene is\u00a0Associated with Reduced Risk of\u00a0Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"53","author":[{"given":"Carl-Henrik","family":"Andersson","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 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