{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:38:14Z","timestamp":1791308294566,"version":"4.3.1"},"reference-count":67,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,11,19]]},"abstract":"<jats:p>\n                    Co-existing depression worsens Alzheimer\u2019s disease (AD) pathology. Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression. This study aimed to compare NGAL levels in healthy controls, AD without depression (AD\u2013D), and AD with co-existing depression (AD+D) patients. Protein levels of NGAL and its receptors, 24p3R and megalin, were assessed in nine brain regions from healthy controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u200a=\u200a19), AD\u2013D (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u200a=\u200a19), and AD+D (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u200a=\u200a21) patients. NGAL levels in AD\u2013D patients were significantly increased in brain regions commonly associated with AD. In the hippocampus, NGAL levels were even further increased in AD+D subjects. Unexpectedly, NGAL levels in the prefrontal cortex of AD+D patients were comparable to those in controls. Megalin levels were increased in BA11 and amygdala of AD+D patients, while no changes in 24p3R were detected. These findings indicate significant differences in neuroimmunological regulation between AD patients with and without co-existing depression. Considering its known effects, elevated NGAL levels might actively promote neuropathological processes in AD with and without depression.\n                  <\/jats:p>","DOI":"10.3233\/jad-160330","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T10:36:18Z","timestamp":1475836578000},"page":"763-776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer\u2019s Disease (AD) Brain Regions: Differential Findings in AD with and without Depression"],"prefix":"10.1177","volume":"55","author":[{"given":"Doortje W.","family":"Dekens","sequence":"first","affiliation":[{"name":"University Medical Center Groningen","place":["The Netherlands"]},{"name":"University of Groningen","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrus 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