{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:43:08Z","timestamp":1788594188931,"version":"build-2803163510"},"reference-count":58,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,10,18]]},"abstract":"<jats:p>\n                    It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer\u2019s disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer\u2019s Prevention(mean age 63.8\u00b17 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated battery(CAB) of seven tests and demographic characteristics, traditional paper-based neuropsychological tests as well as a composite cognitive impairment index, cognitive impairment status(determined by consensus review), and biomarkers for amyloid and tau(CSF phosphorylated-tau\/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    and global PET-PiB burden) and neural injury(CSF neurofilament light protein). CSF and PET-PiB were collected in\n                    <jats:italic>n<\/jats:italic>\n                    \u200a=\u200a71 and\n                    <jats:italic>n<\/jats:italic>\n                    \u200a=\u200a91 participants, respectively, approximately four years prior to CAB testing. For comparison, we examined three traditional tests of delayed memory in parallel. Similar to studies in older samples, the CAB was less influenced by demographic factors than traditional tests. CAB tests were generally correlated with most paper-based cognitive tests examined and mapped onto the same cognitive domains. Greater composite cognitive impairment index was associated with worse performance on all CAB tests. Cognitively impaired participants performed significantly worse compared to normal controls on all but one CAB test. Poorer One Card Learning test performance was associated with higher levels of CSF phosphorylated-tau\/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    . These results support the use of the CogState battery as measures of early cognitive impairment in studies of people at risk for AD.\n                  <\/jats:p>","DOI":"10.3233\/jad-160528","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T10:01:41Z","timestamp":1472810501000},"page":"1395-1408","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Associations between Performance on\u00a0an\u00a0Abbreviated CogState Battery, Other\u00a0Measures of Cognitive Function, and\u00a0Biomarkers in People at Risk for\u00a0Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"54","author":[{"given":"Annie M.","family":"Racine","sequence":"first","affiliation":[{"name":"Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Institute on Aging, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Neuroscience &amp; Public Policy Program, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center, Wm. 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