{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:49:08Z","timestamp":1777394948094,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,1,12]]},"abstract":"<jats:p>The objective of this study was to examine the association of chronotropic response (CR) and heart rate (HR) recovery\u2014 two indices of cardiovascular function within the context of a graded exercise test\u2014 with cognitive performance in a cognitively healthy, late-middle-aged cohort at risk for Alzheimer\u2019s disease (AD). Ninety participants (age\u200a=\u200a63.52\u00b15.86 years; 65.6% female) from the Wisconsin Registry for Alzheimer\u2019s Prevention participated in this study. They underwent graded exercise testing and a comprehensive neuropsychological assessment that assessed the following four cognitive domains: Immediate Memory, Verbal &amp; Learning Memory, Working Memory, and Speed &amp; Flexibility. Regression analyses, adjusted for age, sex, and education, were used to examine the association between CR, HR recovery, and cognition. We found significant associations between CR and cognitive performance in the domains of Immediate Memory, Verbal Learning &amp; Memory, and Speed &amp; Flexibility. In contrast, HR recovery was not significantly associated with cognitive function. The association between CR and cognition persisted even after controlling for HR recovery. Together, these findings indicatethat, in a cognitively normal, late-middle-aged cohort, CR is a stronger correlate of cognitive performance than HR recovery. Overall, this study reinforces the idea that cardiovascular health plays an important role in cognitive function, specifically in a cohort at risk for AD; and that interventions that promote vascular health may be a viable pathway to preventing or slowing cognitive decline due to AD.<\/jats:p>","DOI":"10.3233\/jad-160642","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T10:26:52Z","timestamp":1480674412000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronotropic Response and Cognitive Function in a Cohort at Risk for\u00a0Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"56","author":[{"given":"Lena L.","family":"Law","sequence":"first","affiliation":[{"name":"Geriatric Research Education and Clinical Center, William S. 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