{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:27:11Z","timestamp":1791919631140,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2016,11,19]]},"abstract":"<jats:p>\n                    Apolipoprotein E (APOE)\n                    <jats:italic toggle=\"yes\">\u025b<\/jats:italic>\n                    4 carriers and patients with amnestic mild cognitive impairment (MCI) have high risk of developing Alzheimer\u2019s disease (AD). The Scaffolding Theory of Aging and Cognition proposes that recruitment of additional frontal brain regions can protect cognition against aging. This thesis has yet to be fully tested in older adults at high risk for AD. In the present study, 75 older participants (mean age: 74 years) were included. Applying a voxel-wise approach, fractional amplitude of low-frequency fluctuations (fALFF) in resting-state functional neuroimaging data were analyzed as a function of APOE\n                    <jats:italic toggle=\"yes\">\u025b<\/jats:italic>\n                    4 status (carrier versus noncarrier) and clinical status (healthy control [HC] versus MCI) using a 2\u00d72 analysis of covariance (ANCOVA). Measures of cognition and cerebrospinal fluid levels of amyloid- \u03b2 were also obtained. Three frontal regions were identified with significant interaction effects using ANCOVA (corrected\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u200a&lt;\u200a0.01): left-insula, left-inferior frontal gyrus (IFG), and right-precentral gyrus. The HC\/APOE\n                    <jats:italic toggle=\"yes\">\u025b<\/jats:italic>\n                    <jats:sub>4<\/jats:sub>\n                    carrier group had significantly higher fALFF in all three regions than other groups. In the entire sample, for two regions (left insula and left IFG), a significant positive relationship between amyloid-\u03b2 and memory was only observed among individuals with low fALFF. Our results suggest higher activity in frontal regions may explain being cognitively normal among a subgroup of APOE\n                    <jats:italic toggle=\"yes\">\u025b<\/jats:italic>\n                    4 carriers and protect against the negative impact of AD-associated pathology on memory. This is an observation with potential implications for AD therapeutics.\n                  <\/jats:p>","DOI":"10.3233\/jad-160715","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T11:45:05Z","timestamp":1475581505000},"page":"669-678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Insula and Inferior Frontal Gyrus\u2019 Activities Protect Memory Performance Against Alzheimer\u2019s Disease Pathology in Old Age"],"prefix":"10.1177","volume":"55","author":[{"given":"Feng","family":"Lin","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]},{"name":"University of Rochester Medical Center","place":["USA"]},{"name":"University of Rochester","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ren","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Y.","family":"Lo","sequence":"additional","affiliation":[{"name":"Tzu Chi University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P.","family":"Chapman","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]},{"name":"University of Rochester Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Jacobs","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]},{"name":"University of Rochester Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Baran","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton P.","family":"Porsteinsson","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]},{"name":"University of Rochester Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Foxe","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60630-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01326.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt171"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213815.20177.19"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70191-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.59.103006.093656"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm155"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1280"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20839"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150885.00929.7E"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430701"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu103"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.059"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/907464"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9186-z"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9176-1"},{"key":"e_1_3_2_22_2","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for pipeline data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan Y","year":"2010","unstructured":"Chao-GanY, Yu-FengZ (2010) DPARSF: A MATLAB toolbox for pipeline data analysis of resting-state fMRI. Front Syst Neurosci 4, 13.","journal-title":"Front Syst Neurosci"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.07.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0336"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv181"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335876"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq294"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2900-12.2013"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.11.017"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.007"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24323"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.17.1.85"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.03.021"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4821"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.09.004"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3987-10.2010"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002034"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-014-9270-9"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.1999.6340301.x"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-160715","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:51:46Z","timestamp":1787557906000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-160715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,11,19]]}},"alternative-id":["10.3233\/JAD-160715"],"URL":"https:\/\/doi.org\/10.3233\/jad-160715","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,4]]}}}