{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:05:16Z","timestamp":1793815516345,"version":"4.6.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T00:00:00Z","timestamp":1489795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,4,19]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Cognitive Rehabilitation for Alzheimer\u2019s disease (AD) is an integrative multimodal intervention. It aims to maintain autonomy and quality of life by enhancing the patients\u2019 abilities to compensate for decreased cognitive functioning.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    We evaluated the feasibility of a group\u2013based Cognitive Rehabilitation approach in mild AD dementia and assessed its effect on activities of daily living (ADL).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We included 16 patients with AD dementia in a controlled partial\u2013randomized design. We adapted the manual\u2013guided Cognitive Rehabilitation program (CORDIAL) to a group setting. Over the course of three months, one group received the Cognitive Rehabilitation intervention (\n                    <jats:italic>n<\/jats:italic>\n                    \u200a=\u200a8), while the other group received a standardized Cognitive Training as an active control condition (\n                    <jats:italic>n<\/jats:italic>\n                    \u200a=\u200a8). ADL\u2013competence was measured as primary outcome. The secondary outcome parameters included cognitive abilities related to daily living, functional cognitive state, and non\u2013cognitive domains, e.g., quality of life. For each scale, we assessed the interaction effect \u2018intervention by time\u2019, i.e., from pre\u2013to post\u2013intervention.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    We found no significant interaction effect of intervention by time on the primary outcome ADL\u2013competence. The interaction effect was significant for quality of life (Cohen\u2019s d: \u20131.43), showing an increase in the intervention group compared with the control group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Our study demonstrates the feasibility of a group\u2013based Cognitive Rehabilitation program for patients with mild AD dementia. The Cognitive Rehabilitation showed no significant effect on ADL, possibly reflecting a lack of transfer between the therapy setting and real life. However, the group setting enhanced communication skills and coping mechanisms. Effects on ADL may not have reached statistical significance due to a limited sample size. Furthermore, future studies might use an extended duration of the intervention and integrate caregivers to a greater extent to increase transfer to activities of daily living.\n                  <\/jats:p>","DOI":"10.3233\/jad-160771","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T18:24:09Z","timestamp":1490984649000},"page":"1315-1324","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["Cognitive Rehabilitation in Alzheimer\u2019s Disease: A Controlled Intervention Trial"],"prefix":"10.1177","volume":"57","author":[{"given":"Katharina","family":"Brueggen","sequence":"first","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases, Site Rostock\/Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kasper","sequence":"additional","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases, Site Rostock\/Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Ochmann","sequence":"additional","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases, Site Rostock\/Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Pfaff","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffi","family":"Webel","sequence":"additional","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases, Site Rostock\/Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[{"name":"DZNE German Center for Neurodegenerative Diseases, Site Rostock\/Greifswald, Germany"},{"name":"Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.07.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31827bda55"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt189"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.113"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.01.007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.07.003"},{"key":"e_1_3_2_8_2","first-page":"142","article-title":"Cognitive rehabilitation in Alzheimer\u2019s disease \u2013a conceptual and methodological review","volume":"2","author":"Kasper E","year":"2015","unstructured":"KasperE, OchmannS, HoffmannW, SchneiderW, CavedoE, HampelH, TeipelS (2015) Cognitive rehabilitation in Alzheimer\u2019s disease \u2013a conceptual and methodological review. J Prev Alzheimers Dis 2, 142\u2013152.","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09602010244000020"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.148346"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2086"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514539542"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-100999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000348357"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000800015"},{"key":"e_1_3_2_16_2","volume-title":"Alzheimer-Krankheit. Ein neuropsychologisch-verhaltenstherapeutisches Manual [Alzheimer\u2019s disease, A neuropsychological-behavior therapeutic manual]","author":"Werheid K","year":"2010","unstructured":"WerheidK, Th\u00f6ne-OttoA (2010) Alzheimer-Krankheit. Ein neuropsychologisch-verhaltenstherapeutisches Manual [Alzheimer\u2019s disease, A neuropsychological-behavior therapeutic manual], Beltz."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_2_20_2","author":"World Health Organization","year":"1993","unstructured":"World Health Organization (1993) The ICD-10 classification of mental and behavioural disorders: Diagnostic criteria for research.","journal-title":"The ICD-10 classification of mental and behavioural disorders: Diagnostic criteria for research"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160773"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051195"},{"key":"e_1_3_2_23_2","first-page":"121","article-title":"The Nuremberg Gerontopsychological Inventory as a psychometric assessment in aging brain","volume":"23","author":"Oswald WD","year":"1983","unstructured":"OswaldWD, FleischmannU (1983) The Nuremberg Gerontopsychological Inventory as a psychometric assessment in aging brain. Aging 23, 121\u2013130.","journal-title":"Aging"},{"key":"e_1_3_2_24_2","volume-title":"The Rivermead behavioural memory test","author":"Wilson BA","year":"1991","unstructured":"WilsonBA, CockburnJ, BaddeleyAD (1991) The Rivermead behavioural memory test, Thames Valley Test Company."},{"key":"e_1_3_2_25_2","volume-title":"Handlungsorganisation und Tagesplanung: Testverfahren zur Erfassung der Planungsf\u00e4higkeit im Alltag; HOTAP","author":"Menzel-Begemann A","year":"2010","unstructured":"Menzel-BegemannA (2010) Handlungsorganisation und Tagesplanung: Testverfahren zur Erfassung der Planungsf\u00e4higkeit im Alltag; HOTAP, Hogrefe."},{"key":"e_1_3_2_26_2","volume-title":"Boston diagnostic aphasia examination","author":"Goodglass H","year":"1983","unstructured":"GoodglassH, KaplanE (1983) Boston diagnostic aphasia examination, Lea & Febiger, Philadelphia, PA."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta9100"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1026\/\/0084-5345.28.1.18"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/41.5.652"},{"key":"e_1_3_2_32_2","volume-title":"Improving Reading in Every Class","author":"Thomas EL","year":"1982","unstructured":"ThomasEL, RobinsonHA (1982) Improving Reading in Every Class, Alyn and Bacon, Boston."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-009-9281-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318231e46e"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418130-00003"},{"key":"e_1_3_2_36_2","volume-title":"A compendium of neuropsychological tests: Administration, norms, and commentary","author":"Strauss E","year":"2006","unstructured":"StraussE, ShermanEM, SpreenO (2006) A compendium of neuropsychological tests: Administration, norms, and commentary, American Chemical Society."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709991354"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269215505cr911oa"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610200006360"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2006.00789.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/40.2.206"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515603958"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-36993-3_26"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04337-3"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-160771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:03:33Z","timestamp":1777370613000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-160771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,18]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4,19]]}},"alternative-id":["10.3233\/JAD-160771"],"URL":"https:\/\/doi.org\/10.3233\/jad-160771","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,18]]}}}