{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:01:24Z","timestamp":1791907284231,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,1,12]]},"abstract":"<jats:p>Background: Patients presenting with the classical idiopathic normal pressure hydrocephalus (iNPH) triad often show additional parkinsonian spectrum signs. Accurate differential diagnosis strongly influences the long-term outcome of cerebrospinal fluid (CSF) shunting.<\/jats:p>\n                  <jats:p>Objective: The aim of this study was to find potential CSF microRNA (miRNA) biomarkers for NPH mimics with parkinsonian syndromes that can reliably distinguish them from iNPH patients.<\/jats:p>\n                  <jats:p>Methods: Two cohorts of 81 patients (cohort 1, n\u200a=\u200a55; cohort 2, n\u200a=\u200a26) with possible iNPH who were treated in two centers between January 2011 and May 2014 were studied. In both cohorts, CSF samples were obtained from patients clinically diagnosed with iNPH ( n\u200a=\u200a21 and n\u200a=\u200a10, respectively), possible iNPH with parkinsonian spectrum (PS) ( n\u200a=\u200a18, n\u200a=\u200a10, respectively), possible iNPH with Alzheimer\u2019s disease (AD) ( n\u200a=\u200a16), and non-affected elderly individuals (NC) ( n\u200a=\u200a6). A\u00a0three-step qRT-PCR analysis of the CSF samples was performed to detect miRNAs that were differentially expressed in the groups.<\/jats:p>\n                  <jats:p>\n                    Results: The expression of hsa-miR-4274 in CSF was decreased in both cohorts of PS group patients (cohort 1: p\u200a&lt;\u200a0.0001, cohort 2: p\u200a&lt;\u200a0.0001), and was able to distinguish PS from iNPH with high accuracy (area under the curve\u200a=\u200a0.908). The CSF concentration of hsa-miR-4274 also correlated with the specific binding ratio of ioflupane (\n                    <jats:sup>123<\/jats:sup>\n                    I) dopamine transporter scan ( r\u200a=\u200a\u20130.494, p\u200a=\u200a0.044). By contrast, the level of hsa-miR-4274 was significantly increased in the PS group after CSF diversion.\n                  <\/jats:p>\n                  <jats:p>Conclusion: Levels of CSF hsa-miR-4274 can differentiate PS from patients with iNPH, AD, and NC. This may be clinically useful for diagnostic purposes and predicting shunt treatment responses.<\/jats:p>","DOI":"10.3233\/jad-160848","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T11:43:48Z","timestamp":1480419828000},"page":"317-325","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Decreased Expression of hsa-miR-4274 in\u00a0Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes"],"prefix":"10.1177","volume":"56","author":[{"given":"Ivana","family":"Jurjevi\u0107","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan"},{"name":"Department of Pharmacology and Department of Neurology, University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, 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