{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:46:46Z","timestamp":1782481606605,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:00:00Z","timestamp":1480118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,1,12]]},"abstract":"<jats:p>The present systematic review is based on the premise that a\u00a0variety of neurodegenerative diseases are accompanied by grey matter atrophy in the brain and meditation may impact this. Given that age is a\u00a0major risk factor for many of these progressive and neurodegenerative diseases and that the percentage of the population over the age of 65 is quickly increasing, there is an obvious need for prompt treatment and prevention advances in research. As there is currently no cure for Alzheimer\u2019s disease and other neurodegenerative diseases, many are seeking non-pharmacological treatment options in attempts to offset the disease-related cognitive and functional declines. On the basis of a\u00a0growing body of research suggesting that meditation is effective in increasing grey matter volume in healthy participants, this paper systematically reviewed the literature regarding the effects of meditation on restoring grey matter volume in healthy individuals and those affected by neurodegeneration. This review searched PubMed, CINAHL, and APA PsycNET to identify original studies that included MRI imaging to measure grey matter volume in meditators and post-mindfulness-based intervention participants compared to controls. Thirteen studies were considered eligible for review and involved a\u00a0wide variety of meditation techniques and included participants with and without cognitive impairment. All studies reported significant increases in grey matter volume in the meditators\/intervention group, albeit in assorted regions of the brain. Limited research exists on the mechanisms through which meditation affects disease-related neurodegeneration, but preliminary evidence suggests that it may offset grey matter atrophy.<\/jats:p>","DOI":"10.3233\/jad-160899","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T11:44:52Z","timestamp":1480419892000},"page":"275-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["The Effects of Meditation on Grey Matter Atrophy and Neurodegeneration: A\u00a0Systematic Review"],"prefix":"10.1177","volume":"56","author":[{"given":"Nicole","family":"Last","sequence":"first","affiliation":[{"name":"University of Guelph-Humber, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Tufts","sequence":"additional","affiliation":[{"name":"University of Guelph-Humber, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie E.","family":"Auger","sequence":"additional","affiliation":[{"name":"University of Guelph-Humber, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,11,26]]},"reference":[{"key":"ref001","unstructured":"OrtmanJ, VelkoffV, HoganH (2014) An Aging Nation: The Older Population in the United States. Census Bureau, Washington, DC, Report No P25\u2013P1140."},{"key":"ref002","unstructured":"Government of Canada (2014) Canada\u2019s population estimates: Age and sex, 2014. Available from: http:\/\/www.statcan.gc.ca\/daily-quotidien\/140926\/dq140926b-eng.htm, September 26, 2014, Accessed January 28, 2016."},{"key":"ref003","unstructured":"Government of Canada (2012) Generations in Canada, Age and sex, 2011 Census. Available from: https:\/\/www12.statcan.gc.ca\/census-recensement\/2011\/as-sa\/98-311-x\/98-311-x2011003_2-eng.cfm, December 21, 2015, Accessed July 18, 2016."},{"key":"ref004","unstructured":"World Health Organization and Alzheimer\u2019s Disease International (2012) Dementia: A\u00a0public health priority. World Health Organization, Geneva, Switzerland, pp. 1\u2013112."},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.02.001"},{"key":"ref006","unstructured":"Alzheimer Society Canada (2016) Dementia numbers in Canada. Available from: http:\/\/www.alzheimer.ca\/en\/About-dementia\/What-is-dementia\/Dementia-numbers, Accessed July 13, 2016."},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199405060-00005"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/60904"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317522"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00139"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1038\/nn1008"},{"key":"ref012","volume-title":"Human Physiology. An integrated approach","author":"Silverthorn D","year":"2016"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300828"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6919"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh498"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.08.006"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1037\/a0018334"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i7.471"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.10.001"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.10.002"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1391"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.06.008"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss076"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12040"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328320012a"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu029"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.03.008"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00398"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.01551"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.061"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154530.72969.11"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06739.x"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.03.044"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs231"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198809000-00003"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008820"},{"key":"ref038","first-page":"160","volume":"1","author":"Crosiers D","year":"2012","journal-title":"Am J\u00a0Neurodegener Dis"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.05.058"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70550-6"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000186598.66243.19"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00017"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-160899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:53Z","timestamp":1777370573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-160899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,26]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,12]]}},"alternative-id":["10.3233\/JAD-160899"],"URL":"https:\/\/doi.org\/10.3233\/jad-160899","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,26]]}}}