{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:38:13Z","timestamp":1777394293157,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,1,12]]},"abstract":"<jats:p>Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer\u2019s disease (AD) are also implicated in the central autonomic nervous system (ANS) regulation. For example, deficits in central cholinergic function in AD could likely lead to autonomic dysfunction. We recently developed a simple, readily applicable evaluation for monitoring ANS disturbances in response to traumatic brain injury (TBI). This ability to monitor TBI allows for the possible detection and targeted prevention of long-term, detrimental brain responses caused by TBI that lead to neurodegenerative diseases such as AD. We randomly selected and extracted de-identified medical record information from subjects who have been assessed using the ANS evaluation protocol. Using machine learning strategies in the analysis of information from individual as well as a combination of ANS evaluation protocol components, we identified a novel prediction model that is effective in correctly segregating between cases with or without a documented history of TBI exposure. Results from our study support the hypothesis that trauma-induced ANS dysfunctions may contribute to clinical TBI features. Because autonomic dysfunction is very common in AD patients it is possible that TBI may also contribute to AD and\/or other forms of dementia through these novel mechanisms. This study provides a novel prediction model to physiologically assess the likelihood of subjects with prior history of TBI to develop clinical TBI complications, such as AD.<\/jats:p>","DOI":"10.3233\/jad-160948","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T10:27:27Z","timestamp":1480674447000},"page":"305-315","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of\u00a0Neurological Disorders in Subjects with\u00a0Prior History of Traumatic Brain Injury: Implications in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"56","author":[{"given":"Lap","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Geriatric Research, Education & Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Legere","sequence":"additional","affiliation":[{"name":"PATCH Chiropractic, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongbin","family":"Li","sequence":"additional","affiliation":[{"name":"AccuraScience, Johnston, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samara","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breanna","family":"Valcarcel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio M.","family":"Pasinetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Geriatric Research, Education & Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140513"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.102343"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.10.010"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0370-3"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2007.27.1.30"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2016-0017"},{"key":"ref007","author":"Edwards G","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63521-1.00034-0"},{"key":"ref009","first-page":"47","volume-title":"Physical Medicine and Rehabilitation Board Review","author":"Elovic E","year":"2004"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181f2d3e8"},{"key":"ref011","volume-title":"Functional Neurology for Practitioners of Manual Therapy","author":"Beck RW","year":"2008"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080353"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200402000-00002"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"ref015","unstructured":"DimitriadonE, HeagertuPJ, LiangKY, ZegerSL (2006) The e1071 Package: Misc Functions of the Department of Statistics, TU Wien."},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-182"},{"key":"ref017","first-page":"14","volume-title":"Proceedings of the 3rd International Conference on Document Analysis and Recognition","author":"Ho TK","year":"1995"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012487302797"},{"key":"ref019","first-page":"18","volume":"2","author":"Liaw A","year":"2002","journal-title":"R News"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-3"},{"key":"ref021","first-page":"41","volume":"3","author":"Rish I","year":"2001","journal-title":"IJCAI 2001 workshop on empirical methods in artificial intelligence"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm344"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-S1-S14"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12553"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb05836.x"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2013.835373"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1497"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12575"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3842"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160222110320"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2015-0017"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.Supplement_2.S28"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.7.857"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-160948","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-160948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:54Z","timestamp":1777370574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-160948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,12]]}},"alternative-id":["10.3233\/JAD-160948"],"URL":"https:\/\/doi.org\/10.3233\/jad-160948","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}