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Although EOAD accounts for less than 5.5% of AD cases, ethical considerations must still be made when performing DBS trials including these participants since a portion of people with EOAD, especially those possessing autosomal-dominant mutations, have an atypical and more aggressive disease progression. These considerations include appropriate patient selection and signing of an informed consent for genetic testing; appropriate study design; potential outcomes that people with EOAD could expect; and accurate interpretation and balanced discussion of trial results. Finally, recommendations for future DBS for AD trials will be made to ensure that EOAD patients will not experience avoidable harms should they be enrolled in these experimental studies.<\/jats:p>","DOI":"10.3233\/jad-161073","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T17:19:35Z","timestamp":1492535975000},"page":"289-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Ethical Considerations for Deep Brain Stimulation Trials in Patients with Early-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"58","author":[{"given":"John Noel M.","family":"Via\u00f1a","sequence":"first","affiliation":[{"name":"University of Tasmania, Hobart, Tasmania, Australia"},{"name":"Ethics, Policy & Public Engagement (EPPE) Program, Australian Research Council Centre of Excellence for Electromaterials Science, Hobart, Tasmania, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin","family":"Bittlinger","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gilbert","sequence":"additional","affiliation":[{"name":"University of Tasmania, Hobart, Tasmania, Australia"},{"name":"Ethics, Policy & Public Engagement (EPPE) Program, Australian Research Council Centre of Excellence for Electromaterials Science, Hobart, Tasmania, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,4,15]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22089"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121579"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160017"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.32"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.04.002"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000263"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160356"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1080\/21507740.2014.951780"},{"key":"ref009","author":"Via\u00f1a J","year":"2017","journal-title":"Neurobiol Aging"},{"key":"ref010","unstructured":"PrinceM, WimoA, GuerchetM, AliG, WuY, PrinaM (2015)\n                      World Alzheimer Report 2015: The Global Impact of Dementia\n                      . 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