{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:51:45Z","timestamp":1787316705719,"version":"build-2736575974"},"reference-count":65,"publisher":"SAGE Publications","issue":"s1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2017,9,15]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and is characterized by the progressive loss of the hippocampal and cortical neurons, which results in memory and cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic and anti-diabetic properties. Traditionally, it was used as a galactagogue and to treat anorexia, fever gastritis, gastric ulcers, and various nervous disorders. However, the neuroprotective effect of fenugreek seed powder against aluminum chloride (AlCl3) induced AD rats has not been analyzed. The result of the present study indicated that the chronic administration of AlCl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of IDE and CDK5 (enzymes involved in the metabolism of tau and amyloid proteins), pTau, GFAP and Iba-1, IL-1\u03b2, IL-6, TNF-\u03b1, iNOS, NF-\u03baB, COX-2, CDK5, BDNF, and STAT3. Our behavioral, biochemical, and molecular studies revealed that the co-administration of fenugreek seed powder significantly attenuated the AlCl3 induced memory deficits, amyloid and tau pathology, oxidative stress, and inflammation in AD rats could be due to the synergistic action of its active components.<\/jats:p>","DOI":"10.3233\/jad-161103","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T11:53:19Z","timestamp":1488282799000},"page":"S209-S220","source":"Crossref","is-referenced-by-count":74,"title":["Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer\u2019s Disease1"],"prefix":"10.1177","volume":"60","author":[{"given":"Asokan","family":"Prema","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arokiasamy","family":"Justin Thenmozhi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamilarasan","family":"Manivasagam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musthafa","family":"Mohamed Essa","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman"},{"name":"Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman"},{"name":"Food and Brain Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles J.","family":"Guillemin","sequence":"additional","affiliation":[{"name":"Neuroinflammation group, Faculty of Medicine and Health Sciences, Deb Bailey MND Research Laboratory, Macquarie University, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-161103_ref1","first-page":"FF01","article-title":"Preventive role of Indian black pepper in animal models of Alzheimer\u2019s disease","volume":"9","author":"Subedee","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"10.3233\/JAD-161103_ref2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1747-4949.2010.00527.x","article-title":"Dementia and stroke: The present and future epidemic","volume":"5","author":"Cumming","year":"2010","journal-title":"Int J Stroke"},{"key":"10.3233\/JAD-161103_ref3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.exger.2010.11.032","article-title":"Chronic mild cerebrovascular dysfunction as a cause for Alzheimer\u2019s disease?","volume":"46","author":"Humpel","year":"2011","journal-title":"Exp Gerontol"},{"key":"10.3233\/JAD-161103_ref4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.expneurol.2008.08.017","article-title":"Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer\u2019s disease","volume":"214","author":"Ribes","year":"2008","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-161103_ref5","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11064-015-1525-1","article-title":"Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer\u2019s disease in Wistar rats","volume":"40","author":"Justin Thenmozhi","year":"2015","journal-title":"Neurochem Res"},{"key":"10.3233\/JAD-161103_ref6","doi-asserted-by":"crossref","unstructured":"Justin Thenmozhi A , William Raja TR , Manivasagam T , Janakiraman U , Mohamed Essa M (2016) Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer\u2019s disease. 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