{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:25:48Z","timestamp":1790871948603,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,5,11]]},"abstract":"<jats:p>Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual\u2019s prevention potential for dementia.<\/jats:p>\n                  <jats:p>Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old.<\/jats:p>\n                  <jats:p>Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual\u2019s LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild\/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2\u200ay, range 1\u201316).<\/jats:p>\n                  <jats:p>Results: In midlife (55\u201369\u200ay, n\u200a=\u200a3,256) and late life (70\u201379\u200ay, n\u200a=\u200a4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80\u201397\u200ay, n\u200a=\u200a1,811), higher LIBRA scores did not increase the risk for dementia.<\/jats:p>\n                  <jats:p>Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.<\/jats:p>","DOI":"10.3233\/jad-161208","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T12:12:41Z","timestamp":1493381561000},"page":"537-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":148,"title":["Modifiable Risk Factors for Prevention of\u00a0Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index"],"prefix":"10.1177","volume":"58","author":[{"given":"Stephanie J.B.","family":"Vos","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.J.","family":"van Boxtel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga J.G.","family":"Schiepers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Deckers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"de Vugt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Carri\u00e8re","sequence":"additional","affiliation":[{"name":"Inserm, U1061, Montpellier, France"},{"name":"University Montpellier, U1061, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Dartigues","sequence":"additional","affiliation":[{"name":"University Bordeaux, ISPED, Centre INSERM U1219 \u2013 Bordeaux Population Health Research Center, Bordeaux, France"},{"name":"INSERM, ISPED, Centre INSERM U1219 \u2013 Bordeaux Population Health Research Center, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Peres","sequence":"additional","affiliation":[{"name":"University Bordeaux, ISPED, Centre INSERM U1219 \u2013 Bordeaux Population Health Research Center, Bordeaux, France"},{"name":"INSERM, ISPED, Centre INSERM U1219 \u2013 Bordeaux Population Health Research Center, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvaine","family":"Artero","sequence":"additional","affiliation":[{"name":"Inserm, U1061, Montpellier, France"},{"name":"University Montpellier, U1061, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Inserm, U1061, Montpellier, France"},{"name":"University Montpellier, U1061, Montpellier, France"},{"name":"Faculty of Medicine, Imperial College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Population Health and Health Determinants Unit, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Scafato","sequence":"additional","affiliation":[{"name":"Population Health and Health Determinants Unit, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"University Hospitals and University of Geneva, Geneva, Switzerland"},{"name":"IRCCS Fatebenefratelli, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Huisman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Sociology, VU University, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannie C.","family":"Comijs","sequence":"additional","affiliation":[{"name":"Department Psychiatry and EMGO Institute for Health and Care Research VU University Medical Center, GGZinGeest, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona F.","family":"Sacuiu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Sahlgrenska University Hospital, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"Skoog","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Irving","sequence":"additional","affiliation":[{"name":"School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans R.J.","family":"Verhey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, 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