{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:16:46Z","timestamp":1789683406120,"version":"4.0.1"},"reference-count":174,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2017,3,21]]},"DOI":"10.3233\/jad-161266","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T10:36:58Z","timestamp":1487327818000},"page":"353-371","source":"Crossref","is-referenced-by-count":65,"title":["Are Major Dementias Triggered by Poor Blood Flow to the Brain? Theoretical Considerations"],"prefix":"10.1177","volume":"57","author":[{"given":"Jack c.","family":"de la Torre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-161266_ref1","first-page":"457","volume-title":"Textbook of Neurointensive Care","author":"Safar","year":"2003"},{"key":"10.3233\/JAD-161266_ref2","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1007\/s11357-014-9680-x","article-title":"Neuronal injury from cardiac arrest. Aging years in minutes","volume":"36","author":"Cherry","year":"2014","journal-title":"Age (Dordr"},{"key":"10.3233\/JAD-161266_ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.resuscitation.2008.10.034","article-title":"Cognitive impairments in survivors of out-of-hospital cardiac arrest: A systematic review","volume":"80","author":"Moulaert","year":"2009","journal-title":"Resuscitation"},{"key":"10.3233\/JAD-161266_ref4","doi-asserted-by":"crossref","first-page":"A3","DOI":"10.1016\/j.resuscitation.2015.03.002","article-title":"Cognitive decline after cardiac arrest\u2013It is more to the picture than hypoxic brain injury","volume":"91","author":"Cronberg","year":"2015","journal-title":"Resuscitation"},{"issue":"Pt 1","key":"10.3233\/JAD-161266_ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/brain\/113.1.27","article-title":"Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age","volume":"113","author":"Leenders","year":"1990","journal-title":"Brain"},{"key":"10.3233\/JAD-161266_ref6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1212\/WNL.0b013e31823a0ef7","article-title":"Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease","volume":"77","author":"Chen","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.neuroimage.2009.07.006","article-title":"Static and dynamic characteristics of cerebral blood flow during the resting state","volume":"48","author":"Zou","year":"2009","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-161266_ref8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/mrm.20023","article-title":"Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability and age and gender effects","volume":"51","author":"Parkes","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.3233\/JAD-161266_ref9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neurobiolaging.2016.05.011","article-title":"Summative effects of vascular risk factors on cortical thickness in mild cognitive impairment","volume":"45","author":"Tchistiakova","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161266_ref10","doi-asserted-by":"crossref","unstructured":"Pavlopoulos E , Jones S , Kosmidis S , Close M , Kim C , Kovalerchik O , Small SA , Kandel ER (2013) Molecular mechanism for age-related memory loss: The histone-binding protein RbAp48. Sci Transl Med 5, 200ra115.","DOI":"10.1126\/scitranslmed.3006373"},{"key":"10.3233\/JAD-161266_ref11","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.STR.0000014421.15948.67","article-title":"Alzheimer disease as a vascular disorder: Nosological evidence","volume":"33","author":"de la Torre","year":"2002","journal-title":"Stroke"},{"key":"10.3233\/JAD-161266_ref12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/WAD.0b013e3182a715bc","article-title":"Midlife cardiovascular risk impacts executive function: Framingham offspring study","volume":"28","author":"Nishtala","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-161266_ref13","first-page":"93","article-title":"Incidence of dementia over three decades in the Framingham Heart Study","volume":"375","author":"Satizabal","year":"2016","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-161266_ref14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-2012-120871","article-title":"A review of the major vascular risk factors related to Alzheimer\u2019s disease","volume":"32","author":"Polidori","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161266_ref15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0197-4580(00)00111-1","article-title":"Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer\u2019s pathogenesis","volume":"21","author":"de la Torre","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161266_ref16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1176\/jnp.12.3.305","article-title":"Vascular dementia and Alzheimer\u2019s disease: Is there a difference? A comparison of symptoms by disease duration","volume":"12","author":"Groves","year":"2000","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JAD-161266_ref17","first-page":"57","article-title":"Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: The HAAS. Honolulu-Asia Aging Study","volume":"21","author":"Petrovitch","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161266_ref18","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/00002093-199912003-00017","article-title":"Overlap between pathology of Alzheimer disease and vascular dementia","volume":"13","author":"Kalaria","year":"1999","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-161266_ref19","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jns.2016.05.021","article-title":"The incidence of post-mortem neurodegenerative and cerebrovascular pathology in mixed dementia","volume":"366","author":"De Reuck","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-161266_ref20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1179\/016164104225017686","article-title":"Brain hypoperfusion: A critical factor in vascular dementia","volume":"26","author":"Rom\u00e1n","year":"2004","journal-title":"Neurol Res"},{"key":"10.3233\/JAD-161266_ref21","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1148\/radiol.14140680","article-title":"Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals","volume":"274","author":"Xekardaki","year":"2015","journal-title":"Radiology"},{"key":"10.3233\/JAD-161266_ref22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1600-0404.1993.tb05512.x","article-title":"Alzheimer\u2019s disease compared with cerebrovascular dementia: Neuropsychological similarities and differences","volume":"87","author":"Villardita","year":"1993","journal-title":"Acta Neurol Scand"},{"key":"10.3233\/JAD-161266_ref23","first-page":"4","article-title":"Parkinson\u2019s disease with dementia, Lewy-body disorders and alpha-synuclein: Recent advances and a case report","volume":"20","author":"Wu","year":"2011","journal-title":"Acta Neurol Taiwan"},{"key":"10.3233\/JAD-161266_ref24","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1440-1789.2007.00803.x","article-title":"The Lewy body in Parkinson\u2019s disease: Molecules implicated in the formation and degradation of alpha-synuclein aggregates","volume":"27","author":"Wakabayashi","year":"2007","journal-title":"Neuropathology"},{"key":"10.3233\/JAD-161266_ref25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000116788","article-title":"Are there sequential morphometrical changes in the nucleus basalis in Alzheimer\u2019s disease?","volume":"32","author":"Kobayashi","year":"1992","journal-title":"Eur Neurol"},{"key":"10.3233\/JAD-161266_ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2005.06.002","article-title":"Lewy bodies in Parkinson\u2019s disease: Protectors or perpetrators?","volume":"195","author":"Harrower","year":"2005","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-161266_ref27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S1474-4422(04)00827-0","article-title":"Lewy-body formation is an aggresome-related process: A hypothesis","volume":"3","author":"Olanow","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-161266_ref28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1074\/jbc.M310994200","article-title":"Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective","volume":"279","author":"Tanaka","year":"2004","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-161266_ref29","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3390\/ijms10030724","article-title":"Molecular pathology of Lewy body diseases","volume":"10","author":"Beyer","year":"2009","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-161266_ref30","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.3233\/JAD-161266_ref31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jnc.13385","article-title":"The relationship between glucocerebrosidase mutations and Parkinson disease","volume":"139","author":"Migdalska-Richards","year":"2016","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-161266_ref32","doi-asserted-by":"crossref","first-page":"23179","DOI":"10.1074\/jbc.M802223200","article-title":"Serine 129 phosphorylation of \u03b1-synuclein induces unfolded protein response-mediated cell death","volume":"283","author":"Sugeno","year":"2008","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-161266_ref33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000113681","article-title":"Pathophysiology of neuronal energy crisis in Alzheimer\u2019s disease","volume":"5","author":"de la Torre","year":"2008","journal-title":"Neurodegener Dis"},{"key":"10.3233\/JAD-161266_ref34","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1742-4658.2007.05639.x","article-title":"ER stress and diseases","volume":"274","author":"Yoshida","year":"2007","journal-title":"FEBS J"},{"key":"10.3233\/JAD-161266_ref35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12344","article-title":"Lewy bodies and the mechanisms of neuronal cell death in Parkinson\u2019s disease and dementia with Lewy bodies","volume":"27","author":"Power","year":"2017","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-161266_ref36","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1126\/science.1067122","article-title":"Toxic proteins in neurodegenerative disease","volume":"296","author":"Taylor","year":"2002","journal-title":"Science"},{"key":"10.3233\/JAD-161266_ref37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1385\/JMN:18:3:229","article-title":"Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase","volume":"18","author":"Elkon","year":"2002","journal-title":"J Mol Neurosci"},{"key":"10.3233\/JAD-161266_ref38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-3-319-34057-9_9","volume-title":"Alzheimer\u2019s turning point: A vascular approach to clinical prevention","author":"de la Torre","year":"2016"},{"key":"10.3233\/JAD-161266_ref39","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1212\/WNL.0b013e3182a2cbd1","article-title":"Risk factors for dementia with Lewy bodies: A case-control study","volume":"81","author":"Boot","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.53.2.413","article-title":"Regional cerebral blood flow difference between dementia with Lewy bodies and AD","volume":"53","author":"Ishii","year":"1999","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12149-014-0911-0","article-title":"Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition","volume":"29","author":"Ishii","year":"2015","journal-title":"Ann Nucl Med"},{"key":"10.3233\/JAD-161266_ref42","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/gps.4263","article-title":"Relationship between regional cerebral blood flow and neuropsychiatric symptoms in dementia with Lewy bodies","volume":"30","author":"Yoshida","year":"2015","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-161266_ref43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1212\/WNL.56.5.643","article-title":"Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD","volume":"56","author":"Lobotesis","year":"2001","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/alzrt248","article-title":"Neuroimaging characteristics of dementia with Lewy bodies","volume":"6","author":"Mak","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-161266_ref45","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3174\/ajnr.A1926","article-title":"Differential diagnosis of dementia with Lewy bodies and Alzheimer disease using combined MR imaging and brain perfusion single-photon emission tomography","volume":"31","author":"Goto","year":"2010","journal-title":"Am J Neuroradiol"},{"key":"10.3233\/JAD-161266_ref46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13195-016-0196-8","article-title":"Brain perfusion in dementia with Lewy bodies and Alzheimer\u2019s disease: An arterial spin labeling MRI study on prodromal and mild dementia stages","volume":"8","author":"Roquet","year":"2016","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-161266_ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.40.1.1","article-title":"The Lewy body variant of Alzheimer\u2019s disease: A clinical and pathologic entity","volume":"40","author":"Hansen","year":"1990","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1192\/bjp.162.3.385","article-title":"The Lewy-body variant of Alzheimer\u2019s disease. Clinical and pathological findings","volume":"162","author":"Forstl","year":"1993","journal-title":"Br J Psychiatry"},{"key":"10.3233\/JAD-161266_ref49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/(SICI)1099-1166(200005)15:5<387::AID-GPS131>3.0.CO;2-9","article-title":"Rivastigmine in the treatment of dementia with Lewy bodies: Preliminary findings from an open trial","volume":"15","author":"McKeith","year":"2000","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-161266_ref50","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/NEN.0b013e3181d88e63","article-title":"Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with Lewy body diseases","volume":"69","author":"Ghebremedhin","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-161266_ref51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1148\/radiol.2343040197","article-title":"Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterialspin-labeling MR imaging: Initial experience","volume":"234","author":"Johnson","year":"2005","journal-title":"Radiology"},{"key":"10.3233\/JAD-161266_ref52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/WAD.0b013e3181b4f736","article-title":"ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia","volume":"24","author":"Chao","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-161266_ref53","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00330-015-3834-9","article-title":"Cerebral perfusion in the predementia stages of Alzheimer\u2019s disease","volume":"26","author":"Binnewijzend","year":"2016","journal-title":"Eur Radiol"},{"key":"10.3233\/JAD-161266_ref54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11682-010-9108-x","article-title":"Association cortex hypoperfusion in mild dementia with Lewy bodies: A potential indicator of cholinergic dysfunction?","volume":"5","author":"Fong","year":"2011","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-161266_ref55","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0891988716656083","article-title":"Revisiting DLB diagnosis: A consideration of prodromal DLB and of the diagnostic overlap with Alzheimer disease","volume":"29","author":"McKeith","year":"2016","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.3233\/JAD-161266_ref56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ana.10069","article-title":"Up-regulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment","volume":"51","author":"DeKosky","year":"2002","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-161266_ref57","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1474-4422(04)00683-0","article-title":"Is Alzheimer\u2019s disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics","volume":"3","author":"de la Torre","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-161266_ref58","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1179\/016164104225016254","article-title":"Alzheimer\u2019s disease is a vasocognopathy: A new term to describe its nature","volume":"26","author":"de la Torre","year":"2004","journal-title":"Neurological Res"},{"key":"10.3233\/JAD-161266_ref59","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1212\/WNL.0000000000002590","article-title":"Brain arterial aging and its relationship to Alzheimer dementia","volume":"86","author":"Gutierrez","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref60","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1212\/WNL.0b013e318217e7a4","article-title":"Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease","volume":"76","author":"Li","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref61","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archneur.66.3.343","article-title":"Contribution of vascular risk factors to the progression in Alzheimer disease","volume":"66","author":"Helzner","year":"2009","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-161266_ref62","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1212\/01.wnl.0000172914.08967.dc","article-title":"Aggregation of vascular risk factors and risk of incident Alzheimer disease","volume":"65","author":"Luchsinger","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref63","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/bpa.12130","article-title":"Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies","volume":"24","author":"Miners","year":"2014","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-161266_ref64","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1212\/01.wnl.0000266638.53185.e7","article-title":"Brain SPECT perfusion of frontotemporal dementia associated with motor neuron disease","volume":"69","author":"Guedj","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref65","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ncl.2007.03.005","article-title":"Frontotemporal lobar degeneration","volume":"25","author":"Josephs","year":"2007","journal-title":"Neurol Clin"},{"issue":"Suppl 1","key":"10.3233\/JAD-161266_ref66","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jnc.13656","article-title":"Advances in neuroimaging in frontotemporal dementia","volume":"138","author":"Gordon","year":"2016","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-161266_ref67","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/09540261.2013.776523","article-title":"The epidemiology of frontotemporal dementia","volume":"25","author":"Onyike","year":"2013","journal-title":"Int Rev Psychiatry"},{"key":"10.3233\/JAD-161266_ref68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000093102","article-title":"Impact of behavioural problems on spousal caregivers: A comparison between Alzheimer\u2019s disease and frontotemporal dementia","volume":"22","author":"de Vugt","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-161266_ref69","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000113418","volume":"25","author":"Mendez","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"Pt 11","key":"10.3233\/JAD-161266_ref70","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1093\/brain\/awl288","article-title":"Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia","volume":"129","author":"Le Ber","year":"2006","journal-title":"Brain"},{"key":"10.3233\/JAD-161266_ref71","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00259-003-1343-6","article-title":"Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer\u2019s disease","volume":"31","author":"Nagao","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-161266_ref72","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0197-4580(00)00231-1","article-title":"Astrocytes degenerate in frontotemporal dementia: Possible relation to hypoperfusion","volume":"22","author":"Martin","year":"2001","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161266_ref73","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1001\/archneur.57.6.861","article-title":"Left frontotemporal hypoperfusion is associated with aggression in patients with dementia","volume":"57","author":"Hirono","year":"2000","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-161266_ref74","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1212\/WNL.0b013e3181f11e35","article-title":"Distinct cerebral perfusion patterns in FTLD and AD","volume":"75","author":"Hu","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref75","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1212\/01.wnl.0000238163.71349.78","article-title":"Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI","volume":"67","author":"Du","year":"2006","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref76","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1159\/000180280","article-title":"Differentiation of early-stage Alzheimer\u2019s disease from other types of dementia using brain perfusion single photon emission computed tomography with easy Z-score imaging system analysis","volume":"26","author":"Waragai","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-161266_ref77","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1034\/j.1600-0404.2002.1o148.x","article-title":"Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer\u2019s disease, frontotemporal dementia and vascular dementia","volume":"105","author":"Varma","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.3233\/JAD-161266_ref78","first-page":"142","article-title":"Clinical diagnosis of frontal lobe dementia and Alzheimer\u2019s disease: Relation to cerebral perfusion, brain atrophy and electroencephalography","volume":"6","author":"Julin","year":"1995","journal-title":"Dementia"},{"key":"10.3233\/JAD-161266_ref79","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/jnnp.2006.106054","article-title":"Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer\u2019s disease","volume":"78","author":"McNeill","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-161266_ref80","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1007\/s00330-014-3172-3","article-title":"Distinct perfusion patterns in Alzheimer\u2019s disease, frontotemporal dementia and dementia with Lewy bodies","volume":"24","author":"Binnewijzend","year":"2014","journal-title":"Eur Radiol"},{"key":"10.3233\/JAD-161266_ref81","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1016\/j.neurobiolaging.2015.07.019","article-title":"Early stage of behavioral variant frontotemporal dementia: Clinical and neuroimaging correlates","volume":"36","author":"Borroni","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"Pt 9","key":"10.3233\/JAD-161266_ref82","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.3233\/JAD-161266_ref83","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11065-008-9056-z","article-title":"The early neuropsychological and behavioral characteristics of frontotemporal dementia","volume":"18","author":"Wittenberg","year":"2008","journal-title":"Neuropsychol Rev"},{"key":"10.3233\/JAD-161266_ref84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2004-6101","article-title":"Frontotemporal mild cognitive impairment","volume":"6","author":"de Mendon\u00e7a","year":"2004","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161266_ref85","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1007\/s00330-015-3696-1","article-title":"Cerebral perfusion and glucose metabolism in Alzheimer\u2019s disease and frontotemporal dementia: Two sides of the same coin?","volume":"25","author":"Verfaillie","year":"2015","journal-title":"Eur Radiol"},{"key":"10.3233\/JAD-161266_ref86","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.1890.sp000321","article-title":"On the regulation of the blood-supply of the brain","volume":"11","author":"Roy","year":"1890","journal-title":"J Physiol"},{"key":"10.3233\/JAD-161266_ref87","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00310651","article-title":"Coupling of function, metabolism, and blood flow in the brain","volume":"14","author":"Kuschinsky","year":"1991","journal-title":"Neurosurg Rev"},{"key":"10.3233\/JAD-161266_ref88","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1212\/WNL.0b013e3182a8237e","article-title":"Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers","volume":"81","author":"Jacova","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref89","first-page":"233","article-title":"18F-FDG PET findings in frontotemporal dementia: An SPM analysis of 29 patients","volume":"46","author":"Jeong","year":"2005","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-161266_ref90","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.3174\/ajnr.A3695","article-title":"PET approaches for diagnosis of dementia","volume":"35","author":"Ishii","year":"2014","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.3233\/JAD-161266_ref91","doi-asserted-by":"crossref","first-page":"583931","DOI":"10.1155\/2015\/583931","article-title":"Precuneus and cingulate cortex atrophy and hypometabolism in patients with Alzheimer\u2019s disease and mild cognitive impairment: MRI and (18)F-FDG PET quantitative analysis using FreeSurfer","volume":"2015","author":"Bailly","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.3233\/JAD-161266_ref92","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neubiorev.2008.09.002","article-title":"Default-mode brain dysfunction in mental disorders: A systematic review","volume":"33","author":"Boyd","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-161266_ref93","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000320991","article-title":"Reduced precuneus deactivation during object naming in patients with mild cognitive impairment, Alzheimer\u2019s disease, and frontotemporal lobar degeneration","volume":"30","author":"Frings","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-161266_ref94","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2967\/jnumed.107.045385","article-title":"Multicenter standardized 18 F-FDG PET diagnosis of mild cognitive impairment, Alzheimer\u2019s disease, and other dementias","volume":"49","author":"Mosconi","year":"2008","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-161266_ref95","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2005.11.002","article-title":"Decline of cerebral glucose metabolism in frontotemporal dementia: A longitudinal 18F-FDG-PET-study","volume":"28","author":"Diehl-Schmid","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161266_ref96","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00259-007-0523-1","article-title":"In vivo amyloid imaging with PET in frontotemporal dementia","volume":"35","author":"Engler","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-161266_ref97","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2047-9158-2-8","article-title":"Clinic, neuropathology and molecular genetics of frontotemporal dementia: A mini-review","volume":"2","author":"Pan","year":"2013","journal-title":"Transl Neurodegener"},{"key":"10.3233\/JAD-161266_ref98","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1212\/01.WNL.0000055847.17752.E6","article-title":"Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer\u2019s disease?","volume":"60","author":"Ch\u00e9telat","year":"2003","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref99","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12916-016-0719-y","article-title":"Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group","volume":"14","author":"Perneczky","year":"2016","journal-title":"BMC Med"},{"key":"10.3233\/JAD-161266_ref100","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3233\/JAD-160201","article-title":"Changes of cerebral perfusion and functional brain network organization in patients with mild cognitive impairment","volume":"54","author":"Lou","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161266_ref101","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1212\/01.wnl.0000296941.06685.22","article-title":"Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects","volume":"69","author":"Xu","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-161266_ref102","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pscychresns.2011.12.007","article-title":"Regional cerebral blood flow differences in patients with mild cognitive impairment between those who did and did not develop Alzheimer\u2019s disease","volume":"203","author":"Park","year":"2012","journal-title":"Psychiatry Res"},{"key":"10.3233\/JAD-161266_ref103","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40249-016-0143-8","article-title":"Epidemiological characteristics of human prion diseases","volume":"5","author":"Chen","year":"2016","journal-title":"Infect Dis Poverty"},{"key":"10.3233\/JAD-161266_ref104","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1021\/bi00269a050","article-title":"Further purification and characterization of scrapie prions","volume":"21","author":"Prusiner","year":"1982","journal-title":"Biochemistry"},{"key":"10.3233\/JAD-161266_ref105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/bmb\/66.1.213","article-title":"Sporadic and familial CJD: Classification and characterisation","volume":"66","author":"Gambetti","year":"2003","journal-title":"Br Med Bull"},{"key":"10.3233\/JAD-161266_ref106","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1055\/s-0033-1359314","article-title":"Prion diseases","volume":"33","author":"Takada","year":"2013","journal-title":"Semin Neurol"},{"key":"10.3233\/JAD-161266_ref107","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneurol.2016.65","article-title":"Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease","volume":"12","author":"Zanusso","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-161266_ref108","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.nbd.2005.04.002","article-title":"Aggravation of ischemic brain injury by prion protein deficiency: Role of ERK-1\/-2 and STAT-1","volume":"20","author":"Spudich","year":"2005","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-161266_ref109","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1086\/505215","article-title":"Creutzfeldt-Jakob disease: A rare cause of dementia in elderly persons","volume":"43","author":"Knight","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.3233\/JAD-161266_ref110","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","article-title":"Protein misfolding, functional amyloid, and human disease","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu Rev Biochem"},{"key":"10.3233\/JAD-161266_ref111","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ejmech.2016.08.006","article-title":"Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review","volume":"124","author":"Khanam","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.3233\/JAD-161266_ref112","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/ijms17030327","article-title":"Endoplasmic reticulum stress and associated ROS","volume":"17","author":"Zeeshan","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-161266_ref113","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/B978-0-12-385116-1.00015-7","article-title":"Endoplasmic reticulum stress in brain damage","volume":"489","author":"Raghubir","year":"2011","journal-title":"Methods Enzymol"},{"key":"10.3233\/JAD-161266_ref114","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1126\/science.1068408","article-title":"Molecular chaperones in the cytosol: From nascent chain to folded protein","volume":"295","author":"Hartl","year":"2002","journal-title":"Science"},{"key":"10.3233\/JAD-161266_ref115","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/bip.22361","article-title":"ATP-driven molecular chaperone machines","volume":"99","author":"Clare","year":"2013","journal-title":"Biopolymers"},{"key":"10.3233\/JAD-161266_ref116","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tips.2006.10.005","article-title":"Bioenergetics and the formation of mitochondrial reactive oxygen species","volume":"27","author":"Adam-Vizi","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.3233\/JAD-161266_ref117","doi-asserted-by":"crossref","first-page":"526","DOI":"10.7326\/0003-4819-107-4-526","article-title":"Oxygen radicals and human disease","volume":"107","author":"Cross","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.3233\/JAD-161266_ref118","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr Biol"},{"key":"10.3233\/JAD-161266_ref119","first-page":"3","article-title":"Oxidative stress in bacteria and protein damage by reactive oxygen species","volume":"3","author":"Cabiscol","year":"2000","journal-title":"Int Microbiol"},{"key":"10.3233\/JAD-161266_ref120","first-page":"8042","article-title":"Cellular prion protein (PrP(C)) and its role in stress responses","volume":"8","author":"Zeng","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.3233\/JAD-161266_ref121","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/glia.22963","article-title":"Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein","volume":"64","author":"Guitart","year":"2016","journal-title":"Glia"},{"key":"10.3233\/JAD-161266_ref122","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0736-5748(97)00042-7","article-title":"Effects of oxidative stress on prion protein expression in PC12 cells","volume":"15","author":"Brown","year":"1997","journal-title":"Int J Dev Neurosci"},{"key":"10.3233\/JAD-161266_ref123","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0002-9440(10)63291-9","article-title":"Prion protein accumulation and neuroprotection in hypoxic brain damage","volume":"165","author":"McLennan","year":"2004","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-161266_ref124","first-page":"229","article-title":"Neurodegeneration and oxidative stress: Prion disease results from loss of antioxidant defence","volume":"43","author":"Brown","year":"2005","journal-title":"Folia Neuropathol"},{"key":"10.3233\/JAD-161266_ref125","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.201003138","article-title":"Regulation of basal cellular physiology by the homeostatic unfolded protein response","volume":"189","author":"Rutkowski","year":"2010","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-161266_ref126","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.3233\/JAD-161266_ref127","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrc3800","article-title":"The impact of the endoplasmic reticulum protein-folding environment on cancer development","volume":"14","author":"Wang","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.3233\/JAD-161266_ref128","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schroder","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"10.3233\/JAD-161266_ref129","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0306-9877(96)90068-7","article-title":"Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage","volume":"47","author":"Paschen","year":"1996","journal-title":"Med Hypotheses"},{"key":"10.3233\/JAD-161266_ref130","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/jnc.12981","article-title":"Deletion of Atf6a impairs astroglial activation and enhances neuronal death following brain ischemia in mice","volume":"132","author":"Yoshikawa","year":"2014","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-161266_ref131","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/jnc.13016","article-title":"Brain ischemia, endoplasmic reticulum stress, and astroglial activation: New insights","volume":"132","author":"Gulyaeva","year":"2015","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-161266_ref132","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.neuroscience.2007.04.017","article-title":"Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice","volume":"147","author":"Morimoto","year":"2007","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-161266_ref133","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12640-009-9110-5","article-title":"Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia\/reperfusion in rats","volume":"17","author":"Nakka","year":"2010","journal-title":"Neurotox Res"},{"key":"10.3233\/JAD-161266_ref134","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/jcbfm.2012.204","article-title":"Adaptive changes in the neuronal proteome: Mitochondrial energy production, endoplasmic reticulum stress, and ribosomal dysfunction in the cellular response to metabolic stress","volume":"33","author":"Herrmann","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.3233\/JAD-161266_ref135","doi-asserted-by":"crossref","first-page":"E255","DOI":"10.1038\/ncb1101-e255","article-title":"Organelle-specific initiation of cell death pathways","volume":"3","author":"Ferri","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.3233\/JAD-161266_ref136","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep"},{"key":"10.3233\/JAD-161266_ref137","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jocn.2014.05.040","article-title":"Reduced cerebral blood flow in genetic prion disease with PRNP D178N-129M mutation: An arterial spin labeling MRI study","volume":"22","author":"Chen","year":"2015","journal-title":"J Clin Neurosci"},{"key":"10.3233\/JAD-161266_ref138","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1474-4422(12)70238-7","article-title":"Endoplasmic reticulum dysfunction in neurological disease","volume":"12","author":"Roussel","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-161266_ref139","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.pharmthera.2005.05.008","article-title":"Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease\u2013therapeutic potential","volume":"108","author":"Paschen","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.3233\/JAD-161266_ref140","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuroscience.2015.09.021","article-title":"Hypoxic preconditioning and cell death from oxygen\/glucose deprivation co-opt a subset of the unfolded protein response in hippocampal neurons","volume":"310","author":"Bickler","year":"2015","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-161266_ref141","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat Med"},{"key":"10.3233\/JAD-161266_ref142","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.3233\/JAD-161266_ref143","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrn1587","article-title":"Modulation of neurodegeneration by molecular chaperones","volume":"6","author":"Muchowski","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-161266_ref144","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/jnr.23777","article-title":"Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer\u2019s disease","volume":"95","author":"Daulatzai","year":"2017","journal-title":"Neurosci Res"},{"issue":"Suppl 1","key":"10.3233\/JAD-161266_ref145","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1007\/s00702-013-1129-3","article-title":"Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle","volume":"122","author":"Popa-Wagner","year":"2015","journal-title":"J Neural Transm (Vienna)"},{"key":"10.3233\/JAD-161266_ref146","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cger.2009.12.005","article-title":"Cardiovascular risk factors, cerebrovascular disease burden, and healthy brain aging","volume":"26","author":"Flicker","year":"2010","journal-title":"Clin Geriatr Med"},{"key":"10.3233\/JAD-161266_ref147","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.arr.2010.04.002","article-title":"Vascular risk factor detection and control may prevent Alzheimer\u2019s disease","volume":"9","author":"de la Torre","year":"2010","journal-title":"Ageing Res Rev"},{"key":"10.3233\/JAD-161266_ref148","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s00330-015-3789-x","article-title":"Early-stage differentiation between presenile Alzheimer\u2019s disease and frontotemporal dementia using arterial spin labeling MRI","volume":"26","author":"Steketee","year":"2016","journal-title":"Eur Radiol"},{"key":"10.3233\/JAD-161266_ref149","first-page":"616","article-title":"SPECT diagnosis of Creutzfeld-Jacob disease","volume":"36","author":"Aharon-Peretz","year":"1995","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-161266_ref150","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jns.2015.09.356","article-title":"Decreased regional cerebral blood flow in the bilateral thalami and medulla oblongata determined by an easy Z-score (eZIS) analysis of (99m)Tc-ECD-SPECT images in a case of MM2-thalamic-type sporadic Creutzfeldt-Jakob disease","volume":"358","author":"Hayashi","year":"2015","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-161266_ref151","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.2967\/jnumed.114.143347","article-title":"18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias","volume":"55","author":"O\u2019Brien","year":"2014","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-161266_ref152","doi-asserted-by":"crossref","unstructured":"Chkraborty A , de Wit NM , van der Flier , de Vries H (2016) The blood-brain barrier in Alzheimer\u2019s disease. Vascul Pharmacol. doi: 10.1016\/j.vph.2016.11.008 [Epub ahead of print]","DOI":"10.1016\/j.vph.2016.11.008"},{"key":"10.3233\/JAD-161266_ref153","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s00415-007-0631-7","article-title":"Cerebral perfusion correlates of conversion to Alzheimer\u2019s disease in amnestic mild cognitive impairment","volume":"254","author":"Caroli","year":"2007","journal-title":"J Neurol"},{"key":"10.3233\/JAD-161266_ref154","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","article-title":"Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam Study","volume":"57","author":"Ruitenberg","year":"2005","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-161266_ref155","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.conb.2008.09.015","article-title":"Liaisons dangereuses: Autophagy, neuronal survival and neurodegeneration","volume":"18","author":"Tooze","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"10.3233\/JAD-161266_ref156","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0014-5793(93)80398-E","article-title":"Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae","volume":"333","author":"Tsukada","year":"1993","journal-title":"FEBS Lett"},{"key":"10.3233\/JAD-161266_ref157","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1666","article-title":"Autophagy: Dual roles in life and death?","volume":"6","author":"Baehrecke","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.3233\/JAD-161266_ref158","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4161\/auto.5.7.9291","article-title":"Protein turnover and inclusion body formation","volume":"5","author":"Mitra","year":"2009","journal-title":"Autophagy"},{"key":"10.3233\/JAD-161266_ref159","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2006","journal-title":"Nature"},{"key":"10.3233\/JAD-161266_ref160","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tins.2006.07.003","article-title":"Autophagy in neurodegenerative disease: Friend, foe or turncoat?","volume":"29","author":"Nixon","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.3233\/JAD-161266_ref161","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3858\/emm.2012.44.2.031","article-title":"Neuronal autophagy and neurodegenerative diseases","volume":"44","author":"Son","year":"2012","journal-title":"Exp Mol Med"},{"key":"10.3233\/JAD-161266_ref162","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"issue":"Pt 1","key":"10.3233\/JAD-161266_ref163","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/brain\/124.1.20","article-title":"Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia","volume":"124","author":"Heiss","year":"2001","journal-title":"Brain"},{"key":"10.3233\/JAD-161266_ref164","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1749-6632.2012.06668.x","article-title":"The ischemic penumbra: How does tissue injury evolve?","volume":"1268","author":"Heiss","year":"2012","journal-title":"Ann NY Acad Sci"},{"key":"10.3233\/JAD-161266_ref165","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroimage.2010.03.008","article-title":"An arterial spin labeling investigation of cerebral blood flow deficits in chronic stroke survivors","volume":"51","author":"Brumm","year":"2010","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-161266_ref166","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10571-015-0261-z","article-title":"The utility of cerebral blood flow as a biomarker of preclinical Alzheimer\u2019s disease","volume":"36","author":"Hays","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-161266_ref167","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3233\/JAD-2002-4606","article-title":"Alzheimer\u2019s disease: How does it start?","volume":"4","author":"de la Torre","year":"2002","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161266_ref168","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000285520","article-title":"The vascular hypothesis of Alzheimer\u2019s disease: Bench to bedside and beyond","volume":"7","author":"de la Torre","year":"2010","journal-title":"Neurodegener Dis"},{"key":"10.3233\/JAD-161266_ref169","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12872-016-0386-0","article-title":"Hypertension and cognitive dysfunction in elderly: Blood pressure management for this global burden","volume":"16","author":"Tadic","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"10.3233\/JAD-161266_ref170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.parkreldis.2015.11.019","article-title":"Orthostatic hypotension, cerebral hypoperfusion, and visuospatial deficits in Lewy body disorders","volume":"22","author":"Robertson","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"10.3233\/JAD-161266_ref171","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.3233\/JAD-161266_ref172","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.neubiorev.2013.06.012","article-title":"The effects of cardiovascular exercise on human memory: A review with meta-analysis","volume":"37","author":"Roig","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-161266_ref173","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1177\/0271678X16645593","article-title":"Comparability of [18F]THK5317 and [11C]PIB blood flow proxy images with [18F]FDG positron emission tomography in Alzheimer\u2019s disease","volume":"37","author":"Rodriguez-Vieitez","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.3233\/JAD-161266_ref174","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.2147\/NDT.S93253","article-title":"Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer\u2019s disease","volume":"11","author":"Moretti","year":"2015","journal-title":"Neuropsychiatr Dis Treat"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-161266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:03:27Z","timestamp":1777370607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-161266"}},"subtitle":[],"editor":[{"given":"Patrizia","family":"Mecocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":174,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-161266","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]}}}