{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:37:27Z","timestamp":1789756647130,"version":"4.0.1"},"reference-count":90,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,6,23]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Presenilin-1 (PSEN1) mutations are the most common cause of familial early onset Alzheimer\u2019s disease (AD). The PSEN1 E280A (E280A) mutation has an autosomal dominant inheritance and is involved in the production of amyloid-\u03b2. The largest family group of carriers with E280A mutation is found in Antioquia, Colombia. The study of mutation carriers provides a unique opportunity to identify brain changes in stages previous to AD. Electroencephalography (EEG) is a low cost and minimally invasiveness technique that enables the following of brain changes in AD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To examine how previous reported differences in EEG for Theta and Alpha-2 rhythms in E280A subjects are related to specific regions in cortex and could be tracked across different ages.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    EEG signals were acquired during resting state from non-carriers and carriers, asymptomatic and symptomatic subjects from E280A kindred from Antioquia, Colombia. Independent component analysis (ICA) and inverse solution methods were used to locate brain regions related to differences in Theta and Alpha-2 bands.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    ICA identified two components, mainly related to the Precuneus, where the differences in Theta and Alpha-2 exist simultaneously at asymptomatic and symptomatic stages. When the ratio between Theta and Alpha-2 is used, significant correlations exist with age and a composite cognitive scale.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Theta and Alpha-2 rhythms are altered in E280A subjects. The alterations are possible to track at Precuneus regions using EEG, ICA, and inverse solution methods.\n                  <\/jats:p>","DOI":"10.3233\/jad-161291","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T14:46:44Z","timestamp":1495810004000},"page":"1229-1244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer\u2019s Disease Detected Using Quantitative Electroencephalography"],"prefix":"10.1177","volume":"58","author":[{"given":"John Fredy","family":"Ochoa","sequence":"first","affiliation":[{"name":"Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Francesc","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Center (CREB), Universitat Polit\u00e8nica de Catalunya (UPC), Barcelona, Spain"},{"name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Edinson","family":"Duque","sequence":"additional","affiliation":[{"name":"Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Andr\u00e9s","family":"Tob\u00f3n","sequence":"additional","affiliation":[{"name":"Neuroscience Group of Antioquia, Medical School, Universidad de Antioquia, Medell\u00edn, Colombia"},{"name":"Neuropsychology and Behavior Group, Medical School, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[{"name":"Neuroscience Group of Antioquia, Medical School, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[{"name":"Neuroscience Group of Antioquia, Medical School, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Ma\u00f1anas","sequence":"additional","affiliation":[{"name":"Department of Automatic Control (ESAII), Biomedical Engineering Research Center (CREB), Universitat Polit\u00e8nica de Catalunya (UPC), Barcelona, Spain"},{"name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alher Mauricio","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00417"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00063"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340027028"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70323-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/153331750301800306"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.107"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.038"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.034"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303299"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70227-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22105"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150214"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.08.282"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1099"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-1070-5"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20861"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227b1b0"},{"key":"e_1_3_3_19_2","first-page":"508","volume-title":"VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paran\u00e1 Argentina 29, 30 & 31 October 2014 SE - 130","author":"Ochoa J","year":"2015","unstructured":"OchoaJ, S\u00e1nchezF, Tob\u00f3nC, DuqueJ, QuirozY, LoperaF, HernandezM. (2015) Effective connectivity changes in presymptomatic Alzheimer\u2019s disease with E280A presenilin-1 mutation gene. In VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paran\u00e1 Argentina 29, 30 & 31 October 2014 SE - 130, BraidotA, HadadA, eds. Springer International Publishing, pp. 508\u2013511."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160803"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160056"},{"key":"e_1_3_3_22_2","first-page":"180741","article-title":"Spectral analysis of EEG in familial Alzheimer\u2019s disease with E280A presenilin-1 mutation gene","volume":"2014","author":"Rodriguez R","year":"2014","unstructured":"RodriguezR, LoperaF, AlvarezA, FernandezY, GalanL, QuirozY, BobesMA (2014) Spectral analysis of EEG in familial Alzheimer\u2019s disease with E280A presenilin-1 mutation gene. Int J Alzheimers Dis 2014, 180741.","journal-title":"Int J Alzheimers Dis"},{"key":"e_1_3_3_23_2","first-page":"165","article-title":"Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer\u2019s","volume":"28","author":"Duque JE","year":"2014","unstructured":"DuqueJE, TobonC, AponteC, OchoaJF, Mu\u00f1ozC, Hern\u00e1ndezAM, QuirozY, LoperaF (2014) Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer\u2019s. CES Med 28, 165\u2013176.","journal-title":"CES Med"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2015.02.008"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00491"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)59007-7"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.03.008"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030135"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-5-25"},{"key":"e_1_3_3_30_2","first-page":"75","article-title":"Review of methods for solving the EEG inverse problem","volume":"1","author":"Domingo Pascual-Marqui R","year":"1999","unstructured":"Domingo Pascual-MarquiR (1999) Review of methods for solving the EEG inverse problem. Int J Bioelectromagn 1, 75\u201386.","journal-title":"Int J Bioelectromagn"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2011.0534"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.11.028"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21475"},{"key":"e_1_3_3_34_2","first-page":"7442","article-title":"Neurophysiological correlates in mild cognitive impairment detected using group independent component analysis","volume":"2015","author":"Ochoa JF","year":"2015","unstructured":"OchoaJF, RuizM, ValleD, DuqueJ, TobonC, AlonsoJF, HernandezAM, MananasMA (2015) Neurophysiological correlates in mild cognitive impairment detected using group independent component analysis. Conf Proc IEEE Eng Med Biol Soc 2015, 7442\u20137445.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.02.001"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.06.015"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2014.01.009"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08927"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"e_1_3_3_40_2","first-page":"655","article-title":"[Validity and reliability of the CERAD-Col neuropsychological battery]","volume":"45","author":"Aguirre-Acevedo DC","unstructured":"Aguirre-AcevedoDC, G\u00f3mezRD, MorenoS, Henao-ArboledaE, MottaM, Mu\u00f1ozC, AranaA, PinedaDA, LoperaF. [Validity and reliability of the CERAD-Col neuropsychological battery]. Rev Neurol 45, 655\u2013660.","journal-title":"Rev Neurol"},{"key":"e_1_3_3_41_2","first-page":"961","article-title":"Improving test-retest reliability of quantitative electroencephalography using different preprocessing approaches","volume":"2016","author":"Suarez X","year":"2016","unstructured":"SuarezX, OchoaJ, DuqueJ (2016) Improving test-retest reliability of quantitative electroencephalography using different preprocessing approaches. Conf Proc IEEE Eng Med Biol Soc 2016, 961\u2013964.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2015.00016"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.05.033"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20359"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.028"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.027"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2011.0081"},{"key":"e_1_3_3_49_2","unstructured":"Pascual-MarquiRD (2007) Discrete 3D distributed linear imaging methods of electric neuronal activity. Part 1: Exact zero error localization. arXiv:0710.3341v2"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.11.015"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195178081.001.0001"},{"key":"e_1_3_3_52_2","unstructured":">Chronux website: http:\/\/chronux.org\/"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23084"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07902.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20175"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.07.021"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0164-3_6"},{"issue":"2","key":"e_1_3_3_59_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/brain\/awv338","article-title":"Cascading network failure across the Alzheimer\u2019s disease spectrum","volume":"139","author":"Jones DT","year":"2015","unstructured":"JonesDT, KnopmanDS, GunterJL, Graff-RadfordJ, VemuriP, BoeveBF, PetersenRC, WeinerMW, JackCR (2015) Cascading network failure across the Alzheimer\u2019s disease spectrum. Brain 139(Pt 2), 547\u2013562.","journal-title":"Brain"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.09.019"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.09.020"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22005"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.005"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101710"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c1de77"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00086"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.04.339"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046289"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.08.019"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140633"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141872"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.03.007"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.12.019"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0086-x"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00047"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00060"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.3720163"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00386-2"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.060"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.09.006"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2010.06.003"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00254"},{"key":"e_1_3_3_83_2","article-title":"How does sensor-space group blind source separation face inter-individual neuroanatomical variability? Insights from a simulation study based on the PALS-B12 atlas","author":"Lio G","year":"2016","unstructured":"LioG, BoulinguezP (2016) How does sensor-space group blind source separation face inter-individual neuroanatomical variability? Insights from a simulation study based on the PALS-B12 atlas. Brain Topogr, doi: 10.1007\/s10548-016-0497-z","journal-title":"Brain Topogr"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.058"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw089"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.012"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21065"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww108"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70228-4"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3314"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-161291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-161291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-161291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:03:56Z","timestamp":1777370636000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-161291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,26]]},"references-count":90,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6,23]]}},"alternative-id":["10.3233\/JAD-161291"],"URL":"https:\/\/doi.org\/10.3233\/jad-161291","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,26]]}}}