{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:23:39Z","timestamp":1791437019583,"version":"4.3.3"},"reference-count":95,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2017,10,3]]},"DOI":"10.3233\/jad-161292","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T11:48:51Z","timestamp":1496749731000},"page":"829-841","source":"Crossref","is-referenced-by-count":27,"title":["A Lipidomics Approach to Assess the\u00a0Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for\u00a0Cognitive Response to Exercise"],"prefix":"10.1177","volume":"60","author":[{"given":"Mahwesh","family":"Saleem","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Dinoff","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I.","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Toronto Rehabilitation Institute, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathiba","family":"Shammi","sequence":"additional","affiliation":[{"name":"Neuropsychology, Sunnybrook HealthSciences Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingshan","family":"Cao","sequence":"additional","affiliation":[{"name":"Evaluative Clinical Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarajya Lakshmi Vattem","family":"Venkata","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman J.","family":"Haughey","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Lanct\u00f4t","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"},{"name":"Toronto Rehabilitation Institute, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-161292_ref2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neurobiolaging.2004.08.009","article-title":"Small hippocampal size in cognitively normal subjects with coronary artery disease","volume":"26","author":"Koschack","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161292_ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.athoracsur.2004.06.085","article-title":"White matter diseasein magnetic resonance imaging predicts cerebral complicationsafter coronary artery bypass grafting","volume":"79","author":"Andr\u00e9ll","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.3233\/JAD-161292_ref4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00392-003-1007-3","article-title":"Neuropathological findings after cardiac surgery-retrospective study over 6 years","volume":"92","author":"Emmrich","year":"2003","journal-title":"Z Kardiol"},{"key":"10.3233\/JAD-161292_ref5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1253\/circj.CJ-10-0762","article-title":"Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly","volume":"75","author":"Kim","year":"2011","journal-title":"Circ J"},{"key":"10.3233\/JAD-161292_ref6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000286959","article-title":"Persistent depressive symptoms after acute coronary syndrome are associated with compromised white matter integrity in the anterior cingulate: A pilot study","volume":"79","author":"Rapp","year":"2010","journal-title":"Psychother Psychosom"},{"key":"10.3233\/JAD-161292_ref7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atherosclerosis.2009.10.039","article-title":"Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study","volume":"210","author":"Geerlings","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.3233\/JAD-161292_ref8","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.neurobiolaging.2008.10.018","article-title":"Coronary heart disease is associated with non-amnestic mild cognitive impairment","volume":"31","author":"Roberts","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161292_ref9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1212\/01.wnl.0000167544.54228.95","article-title":"Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age","volume":"65","author":"Vinkers","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-161292_ref10","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1136\/bmj.308.6944.1604","article-title":"Cardiovascular disease and distribution of cognitive function in elderly people: The Rotterdam Study","volume":"308","author":"Breteler","year":"1994","journal-title":"BMJ"},{"key":"10.3233\/JAD-161292_ref11","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2174\/156720510792231711","article-title":"Atheromatosisextent in coronary artery disease is not correlated withapolipoprotein-E polymorphism and its plasma levels, butassociated with cognitive decline","volume":"7","author":"Lima","year":"2010","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-161292_ref12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer\u2019s disease in the Rotterdam Study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"key":"10.3233\/JAD-161292_ref13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3233\/JAD-150052","article-title":"Impaired cerebralhemodynamics and cognitive performance in patients withatherothrombotic disease","volume":"46","author":"Haratz","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161292_ref14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jagp.2014.09.008","article-title":"White matter microstructural integrity is associated with executive function and processing speed in older adults with coronary artery disease","volume":"23","author":"Santiago","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-161292_ref15","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1212\/WNL.0000000000000312","article-title":"Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities","volume":"82","author":"Wardlaw","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-161292_ref16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21073","article-title":"Atherosclerosis and risk for dementia","volume":"61","author":"van Oijen","year":"2007","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-161292_ref17","first-page":"135","article-title":"Heart disease as a risk factor for dementia","volume":"5","author":"Justin","year":"2013","journal-title":"Clin Epidemiol"},{"key":"10.3233\/JAD-161292_ref18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000026270","article-title":"Cognitive test performance and presence of subclinical cardiovascular disease in the cardiovascular health study","volume":"19","author":"Saxton","year":"2000","journal-title":"Neuroepidemiology"},{"key":"10.3233\/JAD-161292_ref19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/gerona\/59.3.M268","article-title":"Predictors of cognitive decline and mortality of aged people over a 10-year period","volume":"59","author":"Tilvis","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3233\/JAD-161292_ref20","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/HYPERTENSIONAHA.110.149823","article-title":"From blood pressure to physical disability: The role of cognition","volume":"55","author":"Elias","year":"2010","journal-title":"Hypertension"},{"key":"10.3233\/JAD-161292_ref21","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1212\/01.wnl.0000279336.36610.f7","article-title":"Amnestic syndrome of the medial temporal type identifies prodromal AD: A longitudinal study","volume":"69","author":"Sarazin","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-161292_ref22","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/PSY.0b013e318227fff9","article-title":"Verbal memory performance and completion of cardiac rehabilitation in patients with coronary artery disease","volume":"73","author":"Swardfager","year":"2011","journal-title":"Psychosom Med"},{"key":"10.3233\/JAD-161292_ref23","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2459\/JCM.0b013e32832d55fe","article-title":"Two-yearmulticomprehensive secondary prevention program: Favorable effectson cardiovascular functional capacity and coronary risk profileafter acute myocardial infarction","volume":"10","author":"Giallauria","year":"2009","journal-title":"J Cardiovasc Med(Hagerstown)"},{"key":"10.3233\/JAD-161292_ref24","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-161292_ref25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/00207454.2010.531893","article-title":"Improvements in cognitive function following cardiac rehabilitation for older adults with cardiovascular disease","volume":"121","author":"Stanek","year":"2011","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-161292_ref26","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.apmr.2004.03.019","article-title":"The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis","volume":"85","author":"Heyn","year":"2004","journal-title":"Arch Phys Med Rehabil"},{"key":"10.3233\/JAD-161292_ref27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1152\/japplphysiol.00500.2006","article-title":"Exercise, cognition, and the aging brain","volume":"101","author":"Kramer","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.3233\/JAD-161292_ref28","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1001\/archinte.161.14.1703","article-title":"A prospective study of physical activity and cognitive decline in elderly women: Women who walk","volume":"161","author":"Yaffe","year":"2001","journal-title":"Arch Intern Med"},{"key":"10.3233\/JAD-161292_ref29","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1212\/WNL.0b013e3181a92c36","article-title":"Predictors of maintaining cognitive function in older adults: The Health ABC study","volume":"72","author":"Yaffe","year":"2009","journal-title":"Neurology"},{"key":"10.3233\/JAD-161292_ref30","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/archinternmed.2011.277","article-title":"Activity energy expenditure and incident cognitive impairment in older adults","volume":"171","author":"Middleton","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.3233\/JAD-161292_ref31","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/gerona\/61.11.1166","article-title":"Aerobic exercise training increases brain volume in aging humans","volume":"61","author":"Colcombe","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3233\/JAD-161292_ref32","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/j.1532-5415.2010.02966.x","article-title":"Cardiopulmonary fitness is associated with cognitive performance in patients with coronary artery disease","volume":"58","author":"Swardfager","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-161292_ref33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: Aperspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.3233\/JAD-161292_ref34","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s11745-006-5041-6","article-title":"Association of ceramides in human plasma with risk factors of atherosclerosis","volume":"41","author":"Ichi","year":"2006","journal-title":"Lipids"},{"key":"10.3233\/JAD-161292_ref35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1050-1738(01)00143-8","article-title":"Sphingomyelinase activity of LDL: A link between atherosclerosis, ceramide, and apoptosis?","volume":"12","author":"Kinnunen","year":"2002","journal-title":"Trends Cardiovasc Med"},{"key":"10.3233\/JAD-161292_ref36","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1161\/01.ATV.20.12.2614","article-title":"Plasma sphingomyelin level as a risk factor for coronary artery disease","volume":"20","author":"Jiang","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3233\/JAD-161292_ref37","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/aje\/kwj140","article-title":"Plasmasphingomyelin and subclinical atherosclerosis: Findings from themulti-ethnic study of atherosclerosis","volume":"163","author":"Nelson","year":"2006","journal-title":"Am JEpidemiol"},{"key":"10.3233\/JAD-161292_ref38","doi-asserted-by":"crossref","unstructured":"Vasantharekha R , Priyanka HP , Swarnalingam T , Srinivasan AV , ThyagaRajan S (2016) Interrelationship between Mini-Mental State Examination scores and biochemical parameters in patients with mild cognitive impairment and Alzheimer\u2019s disease. Geriatr Gerontol Int, in press. doi: 10.1111\/ggi.12957","DOI":"10.1111\/ggi.12957"},{"key":"10.3233\/JAD-161292_ref39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JAD-160826","article-title":"Updating the evidenceon the association between serum cholesterol and risk of late-lifedementia: Eview and meta-analysis","volume":"56","author":"Anstey","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161292_ref40","doi-asserted-by":"crossref","first-page":"e73094","DOI":"10.1371\/journal.pone.0073094","article-title":"Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson\u2019s disease and associated with cognitive impairment: A pilot study","volume":"8","author":"Mielke","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-161292_ref41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2318-13-135","article-title":"Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: A prospective cohort pilot study","volume":"13","author":"Saleem","year":"2013","journal-title":"BMC Geriatr"},{"key":"10.3233\/JAD-161292_ref42","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bbalip.2010.01.010","article-title":"Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer\u2019s disease","volume":"1801","author":"Han","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-161292_ref43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neurobiolaging.2008.03.011","article-title":"Serum sphingomyelins and ceramides are early predictorsof memory impairment","volume":"31","author":"Mielke","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161292_ref44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1212\/WNL.0b013e318264e380","article-title":"Serum ceramides increase the risk of Alzheimer disease: The Women\u2019s Health and Aging Study II","volume":"79","author":"Mielke","year":"2012","journal-title":"Neurology"},{"key":"10.3233\/JAD-161292_ref45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3233\/JAD-2011-110405","article-title":"Plasma sphingomyelins are associated with cognitive progression in Alzheimer\u2019s disease","volume":"27","author":"Mielke","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161292_ref46","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.neurobiolaging.2014.05.019","article-title":"Cerebrospinal fluid sphingolipids, \u03b2-amyloid, and tau in adults at risk for Alzheimer\u2019s disease","volume":"35","author":"Mielke","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161292_ref47","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jalz.2010.03.014","article-title":"Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss","volume":"6","author":"Mielke","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-161292_ref48","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1111\/bph.13557","article-title":"The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice","volume":"173","author":"Sun","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.3233\/JAD-161292_ref49","doi-asserted-by":"crossref","first-page":"e685","DOI":"10.1038\/tp.2015.179","article-title":"Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory","volume":"5","author":"Efstathopoulos","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.3233\/JAD-161292_ref50","first-page":"449","article-title":"Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer\u2019s disease model rats","volume":"12","author":"Asle-Rousta","year":"2013","journal-title":"EXCLI J"},{"key":"10.3233\/JAD-161292_ref51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbr.2013.06.016","article-title":"Neurorestorative effect of FTY720 in a rat model of Alzheimer\u2019s disease: Comparison with memantine","volume":"252","author":"Hemmati","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.3233\/JAD-161292_ref52","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0021-9258(18)52461-3","article-title":"Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation","volume":"266","author":"Kim","year":"1991","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-161292_ref53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.brainresrev.2008.10.001","article-title":"Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration","volume":"59","author":"Arboleda","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.3233\/JAD-161292_ref54","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1074\/jbc.M008096200","article-title":"Kinase suppressor of Ras signals through Thr269 of c-Raf-1","volume":"276","author":"Xing","year":"2001","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-161292_ref55","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/BF03324568","article-title":"Disability and 6-year mortality in elderly population. Role of visual impairment","volume":"16","author":"Cacciatore","year":"2004","journal-title":"Aging Clin Exp Res"},{"key":"10.3233\/JAD-161292_ref56","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/clinchem\/43.9.1657","article-title":"Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes","volume":"43","author":"Zivelin","year":"1997","journal-title":"Clin Chem"},{"key":"10.3233\/JAD-161292_ref57","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.0000237236.88823.47","article-title":"National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards","volume":"37","author":"Hachinski","year":"2006","journal-title":"Stroke"},{"key":"10.3233\/JAD-161292_ref58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1037\/1040-3590.8.2.145","article-title":"Revision of the Brief Visuospatial Memory Test: Studies of normal performance, reliability, and validity","volume":"8","author":"Benedict","year":"1996","journal-title":"Psychol Assess"},{"key":"10.3233\/JAD-161292_ref59","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/01688639508405143","article-title":"Construct validity in the Trail Making Test: What makes Part B harder?","volume":"17","author":"Gaudino","year":"1995","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.3233\/JAD-161292_ref60","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.acn.2003.09.009","article-title":"Speed and memory in the WAIS-III Digit Symbol\u2013Coding subtest across the adult lifespan","volume":"19","author":"Joy","year":"2004","journal-title":"Arch Clin Neuropsychol"},{"key":"10.3233\/JAD-161292_ref61","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The MontrealCognitive Assessment, MoCA: A brief screening tool for mildcognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-161292_ref62","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/archneur.64.9.1323","article-title":"A neuropsychological test battery for use in Alzheimer disease clinical trials","volume":"64","author":"Harrison","year":"2007","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-161292_ref63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/acel.12275","article-title":"Factors affecting longitudinal trajectories ofplasma sphingomyelins: The BaltimoreLongitudinal Study of Aging","volume":"14","author":"Mielke","year":"2015","journal-title":"Aging Cell"},{"key":"10.3233\/JAD-161292_ref64","first-page":"CD005381","article-title":"Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment","author":"Angevaren","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-161292_ref65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12682","article-title":"Cognitive plasticity in older adults: Effects of cognitive training and physical exercise","volume":"1337","author":"Bherer","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"10.3233\/JAD-161292_ref66","first-page":"CD005381","article-title":"Aerobic exercise to improve cognitive function in older people without known cognitive impairment","author":"Young","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-161292_ref67","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bbi.2011.04.017","article-title":"Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease","volume":"25","author":"Swardfager","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.3233\/JAD-161292_ref68","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.neurobiolaging.2009.08.001","article-title":"Physical activity and memory functions: An interventional study","volume":"32","author":"Ruscheweyh","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-161292_ref69","first-page":"23","article-title":"Using network science to evaluate exercise-associated brain changes in older adults","volume":"2","author":"Burdette","year":"2010","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-161292_ref70","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1073\/pnas.0611721104","article-title":"Ancorrelate of exercise-induced neurogenesis in the adult dentategyrus","volume":"104","author":"Pereira","year":"2007","journal-title":"Proc Natl Acad SciU S A"},{"key":"10.3233\/JAD-161292_ref71","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/01.CIR.102.12.1351","article-title":"Regular aerobic exercise prevents andrestores age-related declines in endothelium-dependentvasodilation in healthy men","volume":"102","author":"DeSouza","year":"2000","journal-title":"Circulation"},{"key":"10.3233\/JAD-161292_ref72","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1253\/circj.CJ-12-0364","article-title":"Association of lower habitual physical activity level with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease","volume":"76","author":"Luk","year":"2012","journal-title":"Circ J"},{"key":"10.3233\/JAD-161292_ref73","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.neuroscience.2010.10.021","article-title":"Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus","volume":"171","author":"Kanno","year":"2010","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-161292_ref74","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1161\/CIRCULATIONAHA.113.007559","article-title":"Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-\/- mice and rabbits fed a high-fat and -cholesterol diet","volume":"129","author":"Chatterjee","year":"2014","journal-title":"Circulation"},{"key":"10.3233\/JAD-161292_ref75","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db08-1228","article-title":"Plasma ceramides are elevated in obesesubjects with type 2 diabetes and correlate with the severity ofinsulin resistance","volume":"58","author":"Haus","year":"2009","journal-title":"Diabetes"},{"key":"10.3233\/JAD-161292_ref76","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cmet.2015.06.007","article-title":"Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis","volume":"22","author":"Xia","year":"2015","journal-title":"Cell Metab"},{"key":"10.3233\/JAD-161292_ref77","doi-asserted-by":"crossref","first-page":"E398","DOI":"10.1152\/ajpendo.00134.2015","article-title":"Serum sphingolipids: Relationships to insulin sensitivity and changes with exercise in humans","volume":"309","author":"Bergman","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3233\/JAD-161292_ref78","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00125-015-3850-y","article-title":"Muscle sphingolipids during rest and exercise: A C18:0 signature for insulin resistance in humans","volume":"59","author":"Bergman","year":"2016","journal-title":"Diabetologia"},{"key":"10.3233\/JAD-161292_ref79","first-page":"53","article-title":"The role ofinsulin resistance and glucose metabolism dysregulation in thedevelopment of Alzheimer s disease","volume":"68","author":"Arrieta-Cruz","year":"2016","journal-title":"Rev Invest Clin"},{"key":"10.3233\/JAD-161292_ref80","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1176\/jnp.23.2.jnp215","article-title":"Elevated plasma ceramides in depression","volume":"23","author":"Gracia-Garcia","year":"2011","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JAD-161292_ref81","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3233\/JAD-2011-111202","article-title":"Increased ceramide in brains with Alzheimer\u2019s and other neurodegenerative diseases","volume":"29","author":"Filippov","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-161292_ref82","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/acel.12491","article-title":"Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging","volume":"15","author":"Fabbri","year":"2016","journal-title":"Aging Cell"},{"key":"10.3233\/JAD-161292_ref83","doi-asserted-by":"crossref","first-page":"E99","DOI":"10.1152\/ajpendo.00587.2005","article-title":"Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content","volume":"291","author":"Bruce","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3233\/JAD-161292_ref84","doi-asserted-by":"crossref","first-page":"E882","DOI":"10.1152\/ajpendo.00769.2007","article-title":"Exercise-induced alterations in intramyocellular lipids and insulin resistance: The athlete\u2019s paradox revisited","volume":"294","author":"Dube","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3233\/JAD-161292_ref85","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/oby.21117","article-title":"Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes","volume":"23","author":"Kasumov","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"10.3233\/JAD-161292_ref86","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1016\/j.febslet.2005.08.085","article-title":"The relation between sphingomyelinase activity, lipid peroxide oxidation and NO-releasing in mice liver and brain","volume":"579","author":"Alessenko","year":"2005","journal-title":"FEBS Lett"},{"key":"10.3233\/JAD-161292_ref87","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1210\/en.2003-1749","article-title":"Proinflammatory cytokineimpairment of insulin-like growth factor I-induced proteinsynthesis in skeletal muscle myoblasts requires ceramide","volume":"145","author":"Strle","year":"2004","journal-title":"Endocrinology"},{"key":"10.3233\/JAD-161292_ref88","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00421-014-3080-x","article-title":"Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner","volume":"115","author":"Baranowski","year":"2015","journal-title":"Eur J Appl Physiol"},{"key":"10.3233\/JAD-161292_ref89","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1748-1716.2011.02322.x","article-title":"Exercise increases plasma levels of sphingoid base-1 phosphates in humans","volume":"203","author":"Baranowski","year":"2011","journal-title":"Acta Physiol (Oxf)"},{"key":"10.3233\/JAD-161292_ref90","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1046\/j.1471-4159.2003.02219.x","article-title":"Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells","volume":"88","author":"Harada","year":"2004","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-161292_ref91","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0002-9149(99)00103-4","article-title":"Neurocognitive functioning and improvement in quality of life following participation in cardiac rehabilitation","volume":"83","author":"Cohen","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.3233\/JAD-161292_ref92","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2202-11-118","article-title":"Practice effects in healthy adults: A longitudinal study on frequent repetitive cognitive testing","volume":"11","author":"Bartels","year":"2010","journal-title":"BMC Neurosci"},{"key":"10.3233\/JAD-161292_ref93","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.4088\/JCP.09m05810blu","article-title":"Major depressive disorder predicts completion, adherence, and outcomes in cardiac rehabilitation: A prospective cohort study of 195 patients with coronary artery disease","volume":"72","author":"Swardfager","year":"2011","journal-title":"J Clin Psychiatry"},{"key":"10.3233\/JAD-161292_ref94","doi-asserted-by":"crossref","first-page":"S358","DOI":"10.1016\/j.cjca.2016.07.001","article-title":"Ensuring cardiac rehabilitation access for the majority ofthose in need: A call to action for Canada","volume":"32","author":"Grace","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.3233\/JAD-161292_ref95","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/1077558715606261","article-title":"Drivers of racial and ethnic disparities in cardiac rehabilitation use: Patient and provider perspectives","volume":"73","author":"Mead","year":"2016","journal-title":"Med Care Res Rev"},{"key":"10.3233\/JAD-161292_ref96","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1161\/CIRCULATIONAHA.107.701466","article-title":"Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery","volume":"116","author":"Suaya","year":"2007","journal-title":"Circulation"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-161292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:04:54Z","timestamp":1777370694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-161292"}},"subtitle":[],"editor":[{"given":"Michelle","family":"Mielke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Pilar","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":95,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-161292","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]}}}