{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:44:19Z","timestamp":1777394659612,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,6,23]]},"abstract":"<jats:p>\n                    A direct correlation between brain iron and Alzheimer\u2019s disease (AD) raises questions regarding the transport of non-transferrin-bound iron (NTBI), a toxic but less researched pool of circulating iron that is likely to increase due to pathological and\/or iatrogenic systemic iron overload. Here, we compared the distribution of radiolabeled-NTBI (\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI) and transferrin-bound iron (\n                    <jats:sup>59<\/jats:sup>\n                    Fe-Tf) in mouse models of iron overload in the absence or presence of inflammation. Following a short pulse, most of the\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI was taken up by the liver, followed by the kidney, pancreas, and heart. Notably, a strong signal of\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI was detected in the brain ventricular system after 2\u200ah, and the brain parenchyma after 24\u200ah.\n                    <jats:sup>59<\/jats:sup>\n                    Fe-Tf accumulated mainly in the femur and spleen, and was transported to the brain at a much slower rate than\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI. In the kidney,\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI was detected in the cortex after 2\u200ah, and outer medulla after 24 hours. Most of the\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI and\n                    <jats:sup>59<\/jats:sup>\n                    Fe-Tf from the kidney was reabsorbed; negligible amount was excreted in the urine. Acute inflammation increased the uptake of\n                    <jats:sup>59<\/jats:sup>\n                    Fe-NTBI by the kidney and brain from 2\u201324 hours. Chronic inflammation, on the other hand, resulted in sequestration of iron in the liver and kidney, reducing its transport to the brain. These observations provide direct evidence for the transport of NTBI to the brain, and reveal a complex interplay between inflammation and brain iron homeostasis. Further studies are necessary to determine whether transient increase in NTBI due to systemic iron overload is a risk factor for AD.\n                  <\/jats:p>","DOI":"10.3233\/jad-170097","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T14:46:58Z","timestamp":1495810018000},"page":"1109-1119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"58","author":[{"given":"Ajai K.","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpita","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Asthana","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Ashok","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilok","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shounak","family":"Baksi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 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