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Glutathione is an endogenous antioxidant protecting cells from oxidative injury. S-adenosylmethionine (SAM) produced in the methionine cycle is the primary methyl donor and the precursor of glutathione. In this study, the A\u03b2 intrahippocampal injection rat model and cultured SH-SY5Y cells were used to explore the neuroprotective effect of SAM. We found that SAM could protect cells against A\u03b2-induced cellular injury by inhibition of oxidative stress and neuroinflammation. SAM administration could increase the endogenous antioxidant glutathione and potentiate the antioxidant enzymes activities. SAM might act as an antioxidant and be a potential candidate therapy for AD patients.<\/jats:p>","DOI":"10.3233\/jad-170177","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T12:13:09Z","timestamp":1493381589000},"page":"549-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["S-Adenosylmethionine Attenuates Oxidative Stress and Neuroinflammation Induced by Amyloid-\u03b2 Through Modulation of Glutathione Metabolism"],"prefix":"10.1177","volume":"58","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences, Capital Medical University, Beijing, 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