{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:08:41Z","timestamp":1787501321151,"version":"build-2736575974"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2018,4,10]]},"DOI":"10.3233\/jad-170224","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T05:24:16Z","timestamp":1522214656000},"page":"239-253","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic Value of Diffusion Tensor Imaging and Positron Emission Tomography in Early Stages of Frontotemporal Dementia"],"prefix":"10.1177","volume":"63","author":[{"given":"Julia","family":"Kr\u00e4mer","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gero","family":"Lueg","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schiffler","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Vrachimis","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany"},{"name":"Department of Nuclear Medicine, German Oncology Center, Limassol, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Weckesser","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wenning","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Pawlowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Johnen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Teuber","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Social Medicine, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Wersching","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Social Medicine, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Duning","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-170224_ref1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jnc.13656","article-title":"Advances in neuroimaging in frontotemporal dementia","volume":"138","author":"Gordon","year":"2016","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-170224_ref2","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.3233\/JAD-170224_ref3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JAD-131481","article-title":"Regional differences in white matter breakdown between frontotemporal dementia and early-onset Alzheimer\u2019s disease","volume":"39","author":"Lu","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170224_ref4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4329\/wjr.v8.i3.240","article-title":"What can imaging tell us about cognitive impairment and dementia?","volume":"8","author":"Narayanan","year":"2016","journal-title":"World J Radiol"},{"key":"10.3233\/JAD-170224_ref5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0033-1343155","article-title":"Zerebrale Bildgebung bei Demenzen: State-of-the-Art","volume":"40","author":"Boelmans","year":"2013","journal-title":"Aktuelle Neurol"},{"key":"10.3233\/JAD-170224_ref6","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1007\/s00330-013-3005-9","article-title":"The common dementias: A pictorial review","volume":"23","author":"Bhogal","year":"2013","journal-title":"Eur Radiol"},{"key":"10.3233\/JAD-170224_ref7","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration - A consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"10.3233\/JAD-170224_ref8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1533317514524811","article-title":"The added value of 18-fluorodeoxyglucose-positron emission tomography in the diagnosis of the behavioral variant of frontotemporal dementia","volume":"29","author":"Kerklaan","year":"2014","journal-title":"Am J Alzheimers Dis"},{"key":"10.3233\/JAD-170224_ref9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/ana.20425","article-title":"Antemortem diagnosis of frontotemporal lobar degeneration","volume":"57","author":"Knopman","year":"2005","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-170224_ref10","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1001\/archneur.64.6.830","article-title":"Accuracy of the clinical evaluation for frontotemporal dementia","volume":"64","author":"Mendez","year":"2007","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-170224_ref11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000112852","article-title":"Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population","volume":"25","author":"Pijnenburg","year":"2008","journal-title":"Dement Geriatr Cogn"},{"key":"10.3233\/JAD-170224_ref12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000100973","article-title":"Clinical significance of lobar atrophy in frontotemporal dementia: Application of an MRI visual rating scale","volume":"23","author":"Kipps","year":"2007","journal-title":"Dement Geriatr Cogn"},{"key":"10.3233\/JAD-170224_ref13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/WAD.0b013e3181cfe326","article-title":"Clinical characteristics of patients with frontotemporal dementia with and without lobar atrophy on MRI","volume":"24","author":"Koedam","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-170224_ref14","first-page":"128","article-title":"Early diagnosis of the frontal variant of frontotemporal dementia: How sensitive are standard neuroimaging and neuropsychologic tests?","volume":"12","author":"Gregory","year":"1999","journal-title":"Cogn Behav Neurol"},{"key":"10.3233\/JAD-170224_ref15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000444849","article-title":"Diagnostic accuracy of the frontotemporal dementia consensus criteria in the late-onset frontal lobe syndrome","volume":"41","author":"Vijverberg","year":"2016","journal-title":"Dement Geriatr Cogn"},{"key":"10.3233\/JAD-170224_ref16","doi-asserted-by":"crossref","first-page":"e66932","DOI":"10.1371\/journal.pone.0066932","article-title":"Diffusion tensor tractography versus volumetric imaging in the diagnosis of behavioral variant frontotemporal dementia","volume":"8","author":"Santillo","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-170224_ref17","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/WCO.0b013e3283404309","article-title":"Nonprogressive behavioural frontotemporal dementia: Recent developments and clinical implications of the \u2018bvFTD phenocopy syndrome\u2019","volume":"23","author":"Kipps","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"10.3233\/JAD-170224_ref18","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1093\/brain\/awm177","article-title":"FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer\u2019s disease","volume":"130","author":"Foster","year":"2007","journal-title":"Brain"},{"key":"10.3233\/JAD-170224_ref19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/WCO.0b013e32833fd540","article-title":"Biomarkers in frontotemporal lobar degeneration","volume":"23","author":"Grossman","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"10.3233\/JAD-170224_ref20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ana.24296","article-title":"Longitudinal diffusion tensor imaging in frontotemporal dementia","volume":"77","author":"Mahoney","year":"2015","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-170224_ref21","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neuroimage.2010.01.041","article-title":"Dementia induces correlated reductions in white matter integrity and cortical thickness: A multivariate neuroimaging study with sparse canonical correlation analysis","volume":"50","author":"Avants","year":"2010","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170224_ref22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3233\/JAD-141230","article-title":"More atrophy of deep gray matter structures in frontotemporal dementia compared to Alzheimer\u2019s disease","volume":"44","author":"M\u00f6ller","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170224_ref23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3233\/JAD-2012-121156","article-title":"MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes","volume":"33","author":"Zhang","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170224_ref24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1471-244X-14-174","article-title":"Establishing the bidirectional relationship between depression and subclinical arteriosclerosis\u2013rationale, design, and characteristics of the BiDirect Study","volume":"14","author":"Teismann","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.3233\/JAD-170224_ref25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00330-016-4303-9","article-title":"MR imaging of the brain in large cohort studies: Feasibility report of the population- and patient-based BiDirect study","volume":"27","author":"Teuber","year":"2017","journal-title":"Eur Radiol"},{"key":"10.3233\/JAD-170224_ref26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatric Res"},{"key":"10.3233\/JAD-170224_ref27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000007921","article-title":"White matter changes on CT and MRI: An overview of visual rating scales. European Task Force on Age-Related White Matter Changes","volume":"39","author":"Scheltens","year":"1998","journal-title":"Eur Neurol"},{"key":"10.3233\/JAD-170224_ref28","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170224_ref29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.neuroimage.2005.10.054","article-title":"Statistical parametric mapping of brain morphology: Sensitivity is dramatically increased by using brain-extracted images as inputs","volume":"30","author":"Fein","year":"2006","journal-title":"NeuroImage"},{"key":"10.3233\/JAD-170224_ref30","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/cercor\/bhr288","article-title":"White matter damage in frontotemporal lobar degeneration spectrum","volume":"22","author":"Agosta","year":"2012","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-170224_ref31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/archneur.64.2.246","article-title":"Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia","volume":"64","author":"Borroni","year":"2007","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-170224_ref32","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00234-008-0379-5","article-title":"Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography","volume":"50","author":"Matsuo","year":"2008","journal-title":"Neuroradiology"},{"key":"10.3233\/JAD-170224_ref33","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1212\/WNL.0b013e3181d9edde","article-title":"Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia","volume":"74","author":"Whitwell","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-170224_ref34","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1002\/hbm.22468","article-title":"Profiles of white matter tract pathology in frontotemporal dementia","volume":"35","author":"Mahoney","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-170224_ref35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11910-014-0489-x","article-title":"Imaging Frontotemporal Lobar Degeneration","volume":"14","author":"Diehl-Schmid","year":"2014","journal-title":"Curr Neurol Neurosci"},{"key":"10.3233\/JAD-170224_ref36","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1093\/brain\/awp071","article-title":"White matter damage in frontotemporal dementia and Alzheimer\u2019s disease measured by diffusion MRI","volume":"132","author":"Zhang","year":"2009","journal-title":"Brain"},{"key":"10.3233\/JAD-170224_ref37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1055\/s-0028-1083695","article-title":"Neuroimaging in dementia","volume":"28","author":"Vitali","year":"2008","journal-title":"Semin Neurol"},{"key":"10.3233\/JAD-170224_ref38","first-page":"1","article-title":"An advanced white matter tract analysis in frontotemporal dementia and early-onset Alzheimer\u2019s disease","volume":"10","author":"Daianu","year":"2015","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-170224_ref39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(08)70293-X","article-title":"Biomarkers in amyotrophic lateral sclerosis","volume":"8","author":"Turner","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-170224_ref40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/WCO.0b013e3282f4594b","article-title":"Diffusion tensor imaging in mild cognitive impairment and Alzheimer\u2019s disease: A review","volume":"21","author":"Chua","year":"2008","journal-title":"Curr Opin Neurol"},{"key":"10.3233\/JAD-170224_ref41","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1600-0404.2007.00934.x","article-title":"Frontal Behavioural Inventory in the differential diagnosis of dementia","volume":"117","author":"Milan","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"10.3233\/JAD-170224_ref42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbr.2012.08.003","article-title":"Neuroanatomical correlates of behavioural phenotypes in behoural variant of frontotemporal dementia","volume":"235","author":"Borroni","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.3233\/JAD-170224_ref43","volume-title":"Wortproduktionspr\u00fcfung","author":"Blanken","year":"1999"},{"key":"10.3233\/JAD-170224_ref44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mri.2017.09.001","article-title":"Inter-vender and test-retest reliabilities of resting-state functional magnetic resonance imaging: Implications for multi-center imaging studies","volume":"44","author":"Ana","year":"2017","journal-title":"Magn Reson Imaging"},{"key":"10.3233\/JAD-170224_ref45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/RLI.0000000000000237","article-title":"Quantitative, organ-specific interscanner and intrascanner variability for 3 T whole-body magnetic resonance imaging in a multicenter, multivendor study","volume":"51","author":"Schlett","year":"2016","journal-title":"Invest Radiol"},{"key":"10.3233\/JAD-170224_ref46","first-page":"87","article-title":"A multi-center study: Intra-scan and inter-scan variability of diffusion spectrum imaging","volume":"62","author":"Lemkaddem","year":"2012","journal-title":"Magn Reson Imaging"},{"key":"10.3233\/JAD-170224_ref47","first-page":"1322","article-title":"Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers","volume":"81","author":"Jacova","year":"2013","journal-title":"J Neurol"},{"key":"10.3233\/JAD-170224_ref48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00259-015-3170-y","article-title":"Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting","volume":"43","author":"Perani","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-170224_ref49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.nicl.2014.10.009","article-title":"Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting","volume":"6","author":"Perani","year":"2014","journal-title":"Neuroimage Clin"},{"key":"10.3233\/JAD-170224_ref50","doi-asserted-by":"crossref","first-page":"785039","DOI":"10.1155\/2014\/246586","article-title":"A survey of FDG- and amyloid-PET imaging in dementia and GRADE analysis","volume":"2014","author":"Perani","year":"2014","journal-title":"Biomed Res Int"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-170224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:09Z","timestamp":1777370769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-170224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":50,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-170224","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]}}}